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- W3196458976 abstract "The recently discovered modular glucosides (MOGLs) form a large metabolite library derived from combinatorial assembly of moieties from amino acid, neurotransmitter, and lipid metabolism in the model organism C. elegans. Combining CRISPR-Cas9 genome editing, comparative metabolomics, and synthesis, we show that the carboxylesterase homologue Cel-CEST-1.2 is responsible for specific 2-O-acylation of diverse glucose scaffolds with a wide variety of building blocks, resulting in more than 150 different MOGLs. We further show that this biosynthetic role is conserved for the closest homologue of Cel-CEST-1.2 in the related nematode species C. briggsae, Cbr-CEST-2. Expression of Cel-cest-1.2 and MOGL biosynthesis are strongly induced by starvation conditions in C. elegans, one of the premier model systems for mechanisms connecting nutrition and physiology. Cel-cest-1.2-deletion results in early death of adult animals under starvation conditions, providing first insights into the biological functions of MOGLs." @default.
- W3196458976 created "2021-09-13" @default.
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- W3196458976 date "2021-08-30" @default.
- W3196458976 modified "2023-09-29" @default.
- W3196458976 title "Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates <i>C. elegans</i> Starvation Survival" @default.
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- W3196458976 doi "https://doi.org/10.1021/jacs.1c05908" @default.
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