FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196472093> ?p ?o ?g. }

• W3196472093 endingPage "6845" @default.
• W3196472093 startingPage "6833" @default.
• W3196472093 abstract "To investigate the survival benefit and safety of individualized schedules for sunitinib in patients with metastatic renal cell carcinoma (mRCC) through plasma concentration monitoring.A total of 105 patients with mRCC were enrolled. The schedule was adjusted in two ways: therapeutic drug monitoring (TDM) and toxicity-adjusted schedule (TAS). One group of patients were without any schedule adjustment (maintained schedule, MAS). Progression-free survival (PFS), overall survival (OS), tumor response, and adverse events (AEs) were compared. The relationship between AEs and steady-state concentration or consecutive monitoring curves was explored. Further monitoring of individualized schedules was also conducted.Based on the plasma concentration, the schedules of 18 patients were adjusted in the TDM group. The schedules were adjusted in 37 patients due to severe AEs in the TAS group, while 50 patients were without any schedule adjustment. The median PFS and OS were better in the TDM group than the other two groups (p = 0.001 and p = 0.004, respectively). Univariate and multivariate analyses indicated that TDM could decrease the risk of death independently (p = 0.026). Moreover, the incidence of grades 3/4 AEs decreased from 88.9% to 33.3% in the TDM group (p = 0.001). Sunitinib concentration in 150-200ng/mL was regarded as a transitional zone due to severe AEs mainly happened when concentration elevated over it. After TDM, further plasma concentration monitoring indicated that individualized schedules enabled sunitinib concentration to fluctuate in a much safer range.Treatment-related toxicities could be minimized through plasma concentration monitoring. Patients with adjusted schedules by therapeutic drug monitoring could achieve better survival benefits." @default.
• W3196472093 created "2021-09-13" @default.
• W3196472093 creator A5001892235 @default.
• W3196472093 creator A5010446878 @default.
• W3196472093 creator A5014929343 @default.
• W3196472093 creator A5018417778 @default.
• W3196472093 creator A5025567893 @default.
• W3196472093 creator A5026111867 @default.
• W3196472093 creator A5028847615 @default.
• W3196472093 creator A5030769859 @default.
• W3196472093 creator A5042481304 @default.
• W3196472093 creator A5047871723 @default.
• W3196472093 creator A5052689516 @default.
• W3196472093 creator A5065096073 @default.
• W3196472093 creator A5065935918 @default.
• W3196472093 creator A5088232359 @default.
• W3196472093 date "2021-08-01" @default.
• W3196472093 modified "2023-10-03" @default.
• W3196472093 title "Efficacy and Safety of Individualized Schedule of Sunitinib by Drug Monitoring in Patients with Metastatic Renal Cell Carcinoma" @default.
• W3196472093 cites W1490675613 @default.
• W3196472093 cites W1973282535 @default.
• W3196472093 cites W2019607817 @default.
• W3196472093 cites W2044254728 @default.
• W3196472093 cites W2099088585 @default.
• W3196472093 cites W2113788015 @default.
• W3196472093 cites W2123334268 @default.
• W3196472093 cites W2149456801 @default.
• W3196472093 cites W2149613039 @default.
• W3196472093 cites W2155319477 @default.
• W3196472093 cites W2166819037 @default.
• W3196472093 cites W2181830444 @default.
• W3196472093 cites W2345707108 @default.
• W3196472093 cites W2728930563 @default.
• W3196472093 cites W2765957454 @default.
• W3196472093 cites W2803991753 @default.
• W3196472093 cites W2805430385 @default.
• W3196472093 cites W2889642171 @default.
• W3196472093 cites W2910644531 @default.
• W3196472093 doi "https://doi.org/10.2147/cmar.s327029" @default.
• W3196472093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8418361" @default.
• W3196472093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34512023" @default.
• W3196472093 hasPublicationYear "2021" @default.
• W3196472093 type Work @default.
• W3196472093 sameAs 3196472093 @default.
• W3196472093 citedByCount "4" @default.
• W3196472093 countsByYear W31964720932022 @default.
• W3196472093 countsByYear W31964720932023 @default.
• W3196472093 crossrefType "journal-article" @default.
• W3196472093 hasAuthorship W3196472093A5001892235 @default.
• W3196472093 hasAuthorship W3196472093A5010446878 @default.
• W3196472093 hasAuthorship W3196472093A5014929343 @default.
• W3196472093 hasAuthorship W3196472093A5018417778 @default.
• W3196472093 hasAuthorship W3196472093A5025567893 @default.
• W3196472093 hasAuthorship W3196472093A5026111867 @default.
• W3196472093 hasAuthorship W3196472093A5028847615 @default.
• W3196472093 hasAuthorship W3196472093A5030769859 @default.
• W3196472093 hasAuthorship W3196472093A5042481304 @default.
• W3196472093 hasAuthorship W3196472093A5047871723 @default.
• W3196472093 hasAuthorship W3196472093A5052689516 @default.
• W3196472093 hasAuthorship W3196472093A5065096073 @default.
• W3196472093 hasAuthorship W3196472093A5065935918 @default.
• W3196472093 hasAuthorship W3196472093A5088232359 @default.
• W3196472093 hasBestOaLocation W31964720931 @default.
• W3196472093 hasConcept C112705442 @default.
• W3196472093 hasConcept C120665830 @default.
• W3196472093 hasConcept C121332964 @default.
• W3196472093 hasConcept C126322002 @default.
• W3196472093 hasConcept C126894567 @default.
• W3196472093 hasConcept C143998085 @default.
• W3196472093 hasConcept C197934379 @default.
• W3196472093 hasConcept C2777288759 @default.
• W3196472093 hasConcept C2777472916 @default.
• W3196472093 hasConcept C2779490328 @default.
• W3196472093 hasConcept C2780272996 @default.
• W3196472093 hasConcept C29730261 @default.
• W3196472093 hasConcept C38180746 @default.
• W3196472093 hasConcept C61511704 @default.
• W3196472093 hasConcept C71924100 @default.
• W3196472093 hasConceptScore W3196472093C112705442 @default.
• W3196472093 hasConceptScore W3196472093C120665830 @default.
• W3196472093 hasConceptScore W3196472093C121332964 @default.
• W3196472093 hasConceptScore W3196472093C126322002 @default.
• W3196472093 hasConceptScore W3196472093C126894567 @default.
• W3196472093 hasConceptScore W3196472093C143998085 @default.
• W3196472093 hasConceptScore W3196472093C197934379 @default.
• W3196472093 hasConceptScore W3196472093C2777288759 @default.
• W3196472093 hasConceptScore W3196472093C2777472916 @default.
• W3196472093 hasConceptScore W3196472093C2779490328 @default.
• W3196472093 hasConceptScore W3196472093C2780272996 @default.
• W3196472093 hasConceptScore W3196472093C29730261 @default.
• W3196472093 hasConceptScore W3196472093C38180746 @default.
• W3196472093 hasConceptScore W3196472093C61511704 @default.
• W3196472093 hasConceptScore W3196472093C71924100 @default.
• W3196472093 hasLocation W31964720931 @default.
• W3196472093 hasLocation W31964720932 @default.
• W3196472093 hasLocation W31964720933 @default.
• W3196472093 hasOpenAccess W3196472093 @default.
• W3196472093 hasPrimaryLocation W31964720931 @default.

• next