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- W3196493889 endingPage "112075" @default.
- W3196493889 startingPage "112075" @default.
- W3196493889 abstract "Gene therapy may constitute a promising alternative to conventional pharmacological tools and surgeries for epilepsy. For primary epilepsy, a single variant leading to a significant effect is relatively rare, while other forms are considered complex in inheritances with multiple susceptible mutations and impacts from the environment. Gene therapy in preclinical models of epilepsy has attempted to perform antiepileptogenic, anticonvulsant, or disease-modifying effects during epileptogenesis or after establishing the disease. Creating gene vectors tailored for different situations is the key to expanding gene therapy, and choosing the appropriate therapeutic target remains another fundamental problem. A variety of treatment strategies, from overexpressing inhibitory neuropeptides to modulating the expression of neurotransmitters or ion channels, have been tested in animal models. Additionally, emerging new approaches of optogenetics and chemogenetics, as well as genome-editing tools will further boost the prosperity of gene therapy. This review summarizes the experience obtained to date and discusses the challenges and opportunities in clinical translations." @default.
- W3196493889 created "2021-09-13" @default.
- W3196493889 creator A5013938837 @default.
- W3196493889 creator A5044757881 @default.
- W3196493889 date "2021-11-01" @default.
- W3196493889 modified "2023-10-18" @default.
- W3196493889 title "Gene therapy in epilepsy" @default.
- W3196493889 cites W1492931325 @default.
- W3196493889 cites W1508974207 @default.
- W3196493889 cites W1528775247 @default.
- W3196493889 cites W1568672858 @default.
- W3196493889 cites W1585020230 @default.
- W3196493889 cites W1744561736 @default.
- W3196493889 cites W1770971605 @default.
- W3196493889 cites W1901195584 @default.
- W3196493889 cites W1933062462 @default.
- W3196493889 cites W1963713462 @default.
- W3196493889 cites W1966505487 @default.
- W3196493889 cites W1966547101 @default.
- W3196493889 cites W1966728711 @default.
- W3196493889 cites W1968456089 @default.
- W3196493889 cites W1980449150 @default.
- W3196493889 cites W1982903836 @default.
- W3196493889 cites W1984105546 @default.
- W3196493889 cites W1986580087 @default.
- W3196493889 cites W1992195526 @default.
- W3196493889 cites W1993801613 @default.
- W3196493889 cites W1993931144 @default.
- W3196493889 cites W1995956587 @default.
- W3196493889 cites W1996589230 @default.
- W3196493889 cites W1996957734 @default.
- W3196493889 cites W1998854173 @default.
- W3196493889 cites W2000360198 @default.
- W3196493889 cites W2005889466 @default.
- W3196493889 cites W2008033906 @default.
- W3196493889 cites W2008682721 @default.
- W3196493889 cites W2016460935 @default.
- W3196493889 cites W2017500569 @default.
- W3196493889 cites W2021903785 @default.
- W3196493889 cites W2030926288 @default.
- W3196493889 cites W2033034517 @default.
- W3196493889 cites W2035104441 @default.
- W3196493889 cites W2039551908 @default.
- W3196493889 cites W2047140970 @default.
- W3196493889 cites W2049609862 @default.
- W3196493889 cites W2056936019 @default.
- W3196493889 cites W2058026578 @default.
- W3196493889 cites W2068903817 @default.
- W3196493889 cites W2083481360 @default.
- W3196493889 cites W2084652077 @default.
- W3196493889 cites W2085755215 @default.
- W3196493889 cites W2087497808 @default.
- W3196493889 cites W2092384258 @default.
- W3196493889 cites W2094778727 @default.
- W3196493889 cites W2107880305 @default.
- W3196493889 cites W2109588896 @default.
- W3196493889 cites W2109781922 @default.
- W3196493889 cites W2112938540 @default.
- W3196493889 cites W2117395023 @default.
- W3196493889 cites W2134079336 @default.
- W3196493889 cites W2135090875 @default.
- W3196493889 cites W2158790858 @default.
- W3196493889 cites W2159423248 @default.
- W3196493889 cites W2164736823 @default.
- W3196493889 cites W2167237768 @default.
- W3196493889 cites W2184875208 @default.
- W3196493889 cites W2259130379 @default.
- W3196493889 cites W2341751247 @default.
- W3196493889 cites W2385719444 @default.
- W3196493889 cites W2421622109 @default.
- W3196493889 cites W2463399489 @default.
- W3196493889 cites W2469411888 @default.
- W3196493889 cites W2469782527 @default.
- W3196493889 cites W2484015429 @default.
- W3196493889 cites W2552681109 @default.
- W3196493889 cites W2588135385 @default.
- W3196493889 cites W2594931647 @default.
- W3196493889 cites W2604272875 @default.
- W3196493889 cites W2608870281 @default.
- W3196493889 cites W2619128354 @default.
- W3196493889 cites W2708579841 @default.
- W3196493889 cites W2741191097 @default.
- W3196493889 cites W2746053108 @default.
- W3196493889 cites W2765253110 @default.
- W3196493889 cites W2782970592 @default.
- W3196493889 cites W2786712411 @default.
- W3196493889 cites W2789376325 @default.
- W3196493889 cites W2803031115 @default.
- W3196493889 cites W2805504110 @default.
- W3196493889 cites W2873849039 @default.
- W3196493889 cites W2888833044 @default.
- W3196493889 cites W2889100500 @default.
- W3196493889 cites W2889180228 @default.
- W3196493889 cites W2901164297 @default.
- W3196493889 cites W2901917033 @default.
- W3196493889 cites W2911671193 @default.
- W3196493889 cites W2911761011 @default.
- W3196493889 cites W2919724853 @default.