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- W3196501146 abstract "By 1769, it was known to Morgagni that the ductus arteriosus may persist until adulthood. In 1835, Jörg linked delayed postnatal closure with disturbed respiration, a discovery that afterwards was forgotten for a century. When blood gas analysis became available, the association between persisting patency and diminished oxygenation resurfaced. When it became known that prostaglandins played a role in maintaining ductal patency, the development of pharmacologic intervention with cyclooxygenase inhibitors immediately followed. This rapid progress was due to the interaction between basic science, paediatric cardiology, and neonatology disciplines at the Cardiovascular Research Institute in San Francisco, coordinated by Julius Comroe, as well as President Kennedy’s foundation of the National Institute of Child Health and Development. This series of events exemplifies how clinical research became an integrated managed multidisciplinary endeavour in the 20th century." @default.
- W3196501146 created "2021-09-13" @default.
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- W3196501146 date "2021-07-01" @default.
- W3196501146 modified "2023-09-25" @default.
- W3196501146 title "Persisting patency of the ductus arteriosus in the preterm infant" @default.
- W3196501146 doi "https://doi.org/10.1093/med/9780198854807.003.0016" @default.
- W3196501146 hasPublicationYear "2021" @default.
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