Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196503559> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3196503559 endingPage "7" @default.
- W3196503559 startingPage "1" @default.
- W3196503559 abstract "Inflammation is the initial response to acute and chronic tissue damage, which is characterized by redness, swelling, heat, and pain. Natural products derived from plants have specific pharmacological activity and minimal side effects. Brucea javanica is a plant that has an anti-inflammatory effect, this plant contains alkaloid and flavonoid compounds. Flavonoids have the ability to block cyclooxygenase and lipoxygenase while alkaloids as an anti-inflammatory are thought to work by inhibiting prostaglandin H2 PGH2 which is an inflammatory mediator. From the data obtained, there is no complete literature that reviews its use as an anti-inflammatory. The search databases used are as follows: Pubmed, ScienceDirect, and Google Scholar to study the anti-inflammatory activity of Brucea javanica. All recent research articles were published between 2010 to 2021. Based on eligibility, 4 studies were included in this study, consisting of 2 In vivo studies and 2 In vitro and In vivo studies. A series of pharmacological studies have reported that Brucea javanica can block the Nf-kB signaling pathway and decrease the production of inflammatory mediators. It has been reported to be able to inhibit the production of NO, PGE2, TNF-, IL-1β, IL-18IL-23, COX-2, NF-κB, IFN-γ, IL-6, the levels of MPO (Myeloperoxidase), reducing the edema and induce the production of the anti-inflammatory cytokine (IL-4, IL-10 and TGF-β). Brucea javanica also markedly activates Nrf2 expression suppressing the inflammatory response-mediated NLRP3 and NF-κB activation. In addition, the elevated mRNA expression of MMP-1, MMP-3 and RAGE was remarkably inhibited by Brucea javanica, while the mRNA expression of PPAR-γ was significantly enhanced. In vitro and in vivo studies strongly indicate that Brucea javanica has the potential as an anti-inflammatory." @default.
- W3196503559 created "2021-09-13" @default.
- W3196503559 creator A5001719346 @default.
- W3196503559 creator A5011196249 @default.
- W3196503559 creator A5076675474 @default.
- W3196503559 date "2021-09-30" @default.
- W3196503559 modified "2023-10-14" @default.
- W3196503559 title "The Potential Anti-Inflammatory Effects of Brucea javanica (L.) Merr." @default.
- W3196503559 doi "https://doi.org/10.47760/ijpsm.2021.v06i09.001" @default.
- W3196503559 hasPublicationYear "2021" @default.
- W3196503559 type Work @default.
- W3196503559 sameAs 3196503559 @default.
- W3196503559 citedByCount "0" @default.
- W3196503559 crossrefType "journal-article" @default.
- W3196503559 hasAuthorship W3196503559A5001719346 @default.
- W3196503559 hasAuthorship W3196503559A5011196249 @default.
- W3196503559 hasAuthorship W3196503559A5076675474 @default.
- W3196503559 hasBestOaLocation W31965035591 @default.
- W3196503559 hasConcept C150903083 @default.
- W3196503559 hasConcept C181199279 @default.
- W3196503559 hasConcept C185592680 @default.
- W3196503559 hasConcept C203014093 @default.
- W3196503559 hasConcept C203565725 @default.
- W3196503559 hasConcept C207001950 @default.
- W3196503559 hasConcept C2776914184 @default.
- W3196503559 hasConcept C2778690821 @default.
- W3196503559 hasConcept C2779689624 @default.
- W3196503559 hasConcept C2779703632 @default.
- W3196503559 hasConcept C55493867 @default.
- W3196503559 hasConcept C556039675 @default.
- W3196503559 hasConcept C71924100 @default.
- W3196503559 hasConcept C86803240 @default.
- W3196503559 hasConcept C98274493 @default.
- W3196503559 hasConceptScore W3196503559C150903083 @default.
- W3196503559 hasConceptScore W3196503559C181199279 @default.
- W3196503559 hasConceptScore W3196503559C185592680 @default.
- W3196503559 hasConceptScore W3196503559C203014093 @default.
- W3196503559 hasConceptScore W3196503559C203565725 @default.
- W3196503559 hasConceptScore W3196503559C207001950 @default.
- W3196503559 hasConceptScore W3196503559C2776914184 @default.
- W3196503559 hasConceptScore W3196503559C2778690821 @default.
- W3196503559 hasConceptScore W3196503559C2779689624 @default.
- W3196503559 hasConceptScore W3196503559C2779703632 @default.
- W3196503559 hasConceptScore W3196503559C55493867 @default.
- W3196503559 hasConceptScore W3196503559C556039675 @default.
- W3196503559 hasConceptScore W3196503559C71924100 @default.
- W3196503559 hasConceptScore W3196503559C86803240 @default.
- W3196503559 hasConceptScore W3196503559C98274493 @default.
- W3196503559 hasIssue "9" @default.
- W3196503559 hasLocation W31965035591 @default.
- W3196503559 hasOpenAccess W3196503559 @default.
- W3196503559 hasPrimaryLocation W31965035591 @default.
- W3196503559 hasRelatedWork W1578003494 @default.
- W3196503559 hasRelatedWork W1981532440 @default.
- W3196503559 hasRelatedWork W2018075260 @default.
- W3196503559 hasRelatedWork W2065229632 @default.
- W3196503559 hasRelatedWork W2133354441 @default.
- W3196503559 hasRelatedWork W2409353917 @default.
- W3196503559 hasRelatedWork W2777501243 @default.
- W3196503559 hasRelatedWork W2912900185 @default.
- W3196503559 hasRelatedWork W2985850138 @default.
- W3196503559 hasRelatedWork W2129644223 @default.
- W3196503559 hasVolume "6" @default.
- W3196503559 isParatext "false" @default.
- W3196503559 isRetracted "false" @default.
- W3196503559 magId "3196503559" @default.
- W3196503559 workType "article" @default.