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• W3196509669 abstract "Abstract Glioblastoma multiforme (GBM) is the most frequent type of primary astrocytomas. We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A ( AURKA ), Aurora kinase B ( AURKB ), Aurora kinase C ( AURKC ) and Polo-like kinase 1 ( PLK1 ) mitotic checkpoint genes and GBM risk by qPCR genotyping. In silico analysis was performed to evaluate effects of polymorphic biological sequences on protein binding motifs. Chi-square and Fisher statistics revealed a significant difference in genotypes frequencies between GBM patients and controls for AURKB rs2289590 variant ( p = 0.038). Association with decreased GBM risk was demonstrated for AURKB rs2289590 AC genotype (OR = 0.54; 95% CI = 0.33–0.88; p = 0.015). Furthermore, AURKC rs11084490 CG genotype was associated with lower GBM risk (OR = 0.57; 95% CI = 0.34–0.95; p = 0.031). Bioinformatic analysis of rs2289590 polymorphic region identified additional binding site for the Yin-Yang 1 (YY1) transcription factor in the presence of C allele. Our results indicated that rs2289590 in AURKB and rs11084490 in AURKC were associated with a reduced GBM risk. The present study was performed on a less numerous but ethnically homogeneous population. Hence, future investigations in larger and multiethnic groups are needed to strengthen these results." @default.
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• W3196509669 date "2021-08-31" @default.
• W3196509669 modified "2023-09-26" @default.
• W3196509669 title "Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme" @default.
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• W3196509669 doi "https://doi.org/10.1038/s41598-021-96935-y" @default.
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