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• W3196543279 abstract "Abstract Background Drought is a major environmental disaster that causes crop yield loss worldwide. Metabolites are involved in various environmental stress responses of plants. However, the genetic control of metabolomes underlying crop environmental stress adaptation remains elusive. Results Here, we perform non-targeted metabolic profiling of leaves for 385 maize natural inbred lines grown under well-watered as well as drought-stressed conditions. A total of 3890 metabolites are identified and 1035 of these are differentially produced between well-watered and drought-stressed conditions, representing effective indicators of maize drought response and tolerance. Genetic dissections reveal the associations between these metabolites and thousands of single-nucleotide polymorphisms (SNPs), which represented 3415 metabolite quantitative trait loci (mQTLs) and 2589 candidate genes. 78.6% of mQTLs (2684/3415) are novel drought-responsive QTLs. The regulatory variants that control the expression of the candidate genes are revealed by expression QTL (eQTL) analysis of the transcriptomes of leaves from 197 maize natural inbred lines. Integrated metabolic and transcriptomic assays identify dozens of environment-specific hub genes and their gene-metabolite regulatory networks. Comprehensive genetic and molecular studies reveal the roles and mechanisms of two hub genes, Bx12 and ZmGLK44 , in regulating maize metabolite biosynthesis and drought tolerance. Conclusion Our studies reveal the first population-level metabolomes in crop drought response and uncover the natural variations and genetic control of these metabolomes underlying crop drought adaptation, demonstrating that multi-omics is a powerful strategy to dissect the genetic mechanisms of crop complex traits." @default.
• W3196543279 created "2021-09-13" @default.
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• W3196543279 date "2021-09-06" @default.
• W3196543279 modified "2023-10-18" @default.
• W3196543279 title "Genomic basis underlying the metabolome-mediated drought adaptation of maize" @default.
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• W3196543279 cites W1734091752 @default.
• W3196543279 cites W1826853533 @default.
• W3196543279 cites W1967405869 @default.
• W3196543279 cites W1972019946 @default.
• W3196543279 cites W1983534448 @default.
• W3196543279 cites W1983769329 @default.
• W3196543279 cites W1994302475 @default.
• W3196543279 cites W1998106060 @default.
• W3196543279 cites W1999574084 @default.
• W3196543279 cites W2005734688 @default.
• W3196543279 cites W2006998362 @default.
• W3196543279 cites W2014672304 @default.
• W3196543279 cites W2016037818 @default.
• W3196543279 cites W2019182222 @default.
• W3196543279 cites W2032700288 @default.
• W3196543279 cites W2040934209 @default.
• W3196543279 cites W2042032554 @default.
• W3196543279 cites W2043153600 @default.
• W3196543279 cites W2053465517 @default.
• W3196543279 cites W2055850604 @default.
• W3196543279 cites W2055966372 @default.
• W3196543279 cites W2057015734 @default.
• W3196543279 cites W2064013109 @default.
• W3196543279 cites W2078078003 @default.
• W3196543279 cites W2089611985 @default.
• W3196543279 cites W2101538287 @default.
• W3196543279 cites W2107146069 @default.
• W3196543279 cites W2107224469 @default.
• W3196543279 cites W2110035718 @default.
• W3196543279 cites W2118643445 @default.
• W3196543279 cites W2121769890 @default.
• W3196543279 cites W2125683950 @default.
• W3196543279 cites W2129325648 @default.
• W3196543279 cites W2134738614 @default.
• W3196543279 cites W2134990135 @default.
• W3196543279 cites W2136544425 @default.
• W3196543279 cites W2137695274 @default.
• W3196543279 cites W2141916112 @default.
• W3196543279 cites W2146097252 @default.
• W3196543279 cites W2146394721 @default.
• W3196543279 cites W2152285853 @default.
• W3196543279 cites W2167942713 @default.
• W3196543279 cites W2179438025 @default.
• W3196543279 cites W2341820027 @default.
• W3196543279 cites W2342784255 @default.
• W3196543279 cites W2464084885 @default.
• W3196543279 cites W2515929567 @default.
• W3196543279 cites W2531343340 @default.
• W3196543279 cites W2554772196 @default.
• W3196543279 cites W2556974986 @default.
• W3196543279 cites W2564219696 @default.
• W3196543279 cites W2566127063 @default.
• W3196543279 cites W2589515024 @default.
• W3196543279 cites W2620979810 @default.
• W3196543279 cites W2713757953 @default.
• W3196543279 cites W2747618428 @default.
• W3196543279 cites W2750845585 @default.
• W3196543279 cites W2777417958 @default.
• W3196543279 cites W2783749221 @default.
• W3196543279 cites W2789752005 @default.
• W3196543279 cites W2791879373 @default.
• W3196543279 cites W2800921920 @default.
• W3196543279 cites W2804723813 @default.
• W3196543279 cites W2810803826 @default.
• W3196543279 cites W2889860329 @default.
• W3196543279 cites W2896828227 @default.
• W3196543279 cites W2898653095 @default.
• W3196543279 cites W2902284009 @default.
• W3196543279 cites W2914247931 @default.
• W3196543279 cites W2946411674 @default.
• W3196543279 cites W2949115188 @default.
• W3196543279 cites W2982691670 @default.
• W3196543279 cites W2995276351 @default.
• W3196543279 cites W3005983114 @default.
• W3196543279 cites W3014988254 @default.
• W3196543279 cites W3037321072 @default.
• W3196543279 cites W3040208280 @default.
• W3196543279 cites W3106889297 @default.
• W3196543279 cites W3124945062 @default.
• W3196543279 cites W2987108219 @default.
• W3196543279 doi "https://doi.org/10.1186/s13059-021-02481-1" @default.
• W3196543279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8420056" @default.
• W3196543279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34488839" @default.

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