FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196550489> ?p ?o ?g. }

• W3196550489 endingPage "4357" @default.
• W3196550489 startingPage "4357" @default.
• W3196550489 abstract "A previous study from our group reported that monocyte adhesion to glioblastoma (GBM) promoted tumor growth and invasion activity and increased tumor-associated macrophages (TAMs) proliferation and inflammatory mediator secretion as well. The present study showed that prescribed psychotropic medicine paliperidone reduced GBM growth and immune checkpoint protein programmed death ligand (PD-L)1 expression and increased survival in an intracranial xenograft mouse model. An analysis of the database of patients with glioma showed that the levels of PD-L1 and dopamine receptor D (DRD)2 were higher in the GBM group than in the low grade astrocytoma and non-tumor groups. In addition, GFP expressing GBM (GBM-GFP) cells co-cultured with monocytes-differentiated macrophage enhanced PD-L1 expression in GBM cells. The enhancement of PD-L1 in GBM was antagonized by paliperidone and risperidone as well as DRD2 selective inhibitor L741426. The expression of CD206 (M2 phenotype marker) was observed to be markedly increased in bone marrow-derived macrophages (BMDMs) co-cultured with GBM. Importantly, treatment with paliperidone effectively decreased CD206 and also dramatically increased CD80 (M1 phenotype marker) in BMDMs. We have previously established a PD-L1 GBM-GFP cell line that stably expresses PD-L1. Experiments showed that the expressions of CD206 was increased and CD80 was mildly decreased in the BMDMs co-cultured with PD-L1 GBM-GFP cells. On the other hands, knockdown of DRD2 expression in GBM cells dramatically decreased the expression of CD206 but markedly increased CD80 expressions in BMDMs. The present study suggests that DRD2 may be involved in regulating the PD-L1 expression in GBM and the microenvironment of GBM. Our results provide a valuable therapeutic strategy and indicate that treatments combining DRD2 antagonist paliperidone with standard immunotherapy may be beneficial for GBM treatment." @default.
• W3196550489 created "2021-09-13" @default.
• W3196550489 creator A5006721065 @default.
• W3196550489 creator A5028008344 @default.
• W3196550489 creator A5030197932 @default.
• W3196550489 creator A5041889711 @default.
• W3196550489 creator A5052360517 @default.
• W3196550489 creator A5075713374 @default.
• W3196550489 creator A5082112103 @default.
• W3196550489 creator A5085718879 @default.
• W3196550489 creator A5088397615 @default.
• W3196550489 creator A5088950177 @default.
• W3196550489 date "2021-08-28" @default.
• W3196550489 modified "2023-09-27" @default.
• W3196550489 title "Paliperidone Inhibits Glioblastoma Growth in Mouse Brain Tumor Model and Reduces PD-L1 Expression" @default.
• W3196550489 cites W1480357432 @default.
• W3196550489 cites W1483000871 @default.
• W3196550489 cites W1504508182 @default.
• W3196550489 cites W1548640328 @default.
• W3196550489 cites W1752668680 @default.
• W3196550489 cites W1791497256 @default.
• W3196550489 cites W1815157104 @default.
• W3196550489 cites W1893566975 @default.
• W3196550489 cites W1977912929 @default.
• W3196550489 cites W1999879982 @default.
• W3196550489 cites W2001717792 @default.
• W3196550489 cites W2007315311 @default.
• W3196550489 cites W2027949469 @default.
• W3196550489 cites W2032940213 @default.
• W3196550489 cites W2035156778 @default.
• W3196550489 cites W2040773741 @default.
• W3196550489 cites W2042108941 @default.
• W3196550489 cites W2045821490 @default.
• W3196550489 cites W2048898424 @default.
• W3196550489 cites W2085099489 @default.
• W3196550489 cites W2090248954 @default.
• W3196550489 cites W2096287682 @default.
• W3196550489 cites W2096775351 @default.
• W3196550489 cites W2097278047 @default.
• W3196550489 cites W2097744565 @default.
• W3196550489 cites W2106537986 @default.
• W3196550489 cites W2107408397 @default.
• W3196550489 cites W2111336617 @default.
• W3196550489 cites W2112936527 @default.
• W3196550489 cites W2115480443 @default.
• W3196550489 cites W2116371946 @default.
• W3196550489 cites W2116778886 @default.
• W3196550489 cites W2121232930 @default.
• W3196550489 cites W2125493895 @default.
• W3196550489 cites W2131799762 @default.
• W3196550489 cites W2140521865 @default.
• W3196550489 cites W2144867791 @default.
• W3196550489 cites W2148569007 @default.
• W3196550489 cites W2149387197 @default.
• W3196550489 cites W2157776107 @default.
• W3196550489 cites W2159803625 @default.
• W3196550489 cites W2160834915 @default.
• W3196550489 cites W2161289668 @default.
• W3196550489 cites W2165114272 @default.
• W3196550489 cites W2428936938 @default.
• W3196550489 cites W2564795955 @default.
• W3196550489 cites W2581747126 @default.
• W3196550489 cites W2584371626 @default.
• W3196550489 cites W2595863515 @default.
• W3196550489 cites W2611933195 @default.
• W3196550489 cites W2613790813 @default.
• W3196550489 cites W2615165013 @default.
• W3196550489 cites W2653322994 @default.
• W3196550489 cites W2742462785 @default.
• W3196550489 cites W2742534733 @default.
• W3196550489 cites W2764040657 @default.
• W3196550489 cites W2790751347 @default.
• W3196550489 cites W2794346955 @default.
• W3196550489 cites W2801173377 @default.
• W3196550489 cites W2803166376 @default.
• W3196550489 cites W2896788268 @default.
• W3196550489 cites W2919041616 @default.
• W3196550489 cites W2943087830 @default.
• W3196550489 cites W2946711853 @default.
• W3196550489 cites W2947518394 @default.
• W3196550489 cites W2950749236 @default.
• W3196550489 cites W2990218599 @default.
• W3196550489 cites W2997186639 @default.
• W3196550489 cites W3007328740 @default.
• W3196550489 cites W3009726125 @default.
• W3196550489 cites W3023037803 @default.
• W3196550489 cites W3088730413 @default.
• W3196550489 cites W3091419609 @default.
• W3196550489 cites W4211107382 @default.
• W3196550489 cites W594682156 @default.
• W3196550489 doi "https://doi.org/10.3390/cancers13174357" @default.
• W3196550489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8430966" @default.
• W3196550489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34503167" @default.
• W3196550489 hasPublicationYear "2021" @default.
• W3196550489 type Work @default.
• W3196550489 sameAs 3196550489 @default.
• W3196550489 citedByCount "6" @default.
• W3196550489 countsByYear W31965504892021 @default.

• next