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- W3196556489 abstract "The dynamic process of mitotic spindle assembly depends on multitudes of inter-dependent interactions involving kinetochores (KTs), microtubules (MTs), spindle pole bodies (SPBs), and molecular motors. Before forming the mitotic spindle, multiple visible microtubule organizing centers (MTOCs) coalesce into a single focus to serve as an SPB in the pathogenic budding yeast, Cryptococcus neoformans. To explain this unusual phenomenon in the fungal kingdom, we propose a search and capture model, in which cytoplasmic MTs (cMTs) nucleated by MTOCs grow and capture each other to promote MTOC clustering. Our quantitative modeling identifies multiple redundant mechanisms mediated by a combination of cMT-cell cortex interactions and inter-cMT coupling to facilitate MTOC clustering within the physiological time limit as determined by time-lapse live-cell microscopy. Besides, we screen various possible mechanisms by computational modeling and propose optimal conditions that favor proper spindle positioning-a critical determinant for timely chromosome segregation. These analyses also reveal that a combined effect of MT buckling, dynein pull, and cortical push maintains spatiotemporal spindle localization." @default.
- W3196556489 created "2021-09-13" @default.
- W3196556489 creator A5009563894 @default.
- W3196556489 creator A5021741801 @default.
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- W3196556489 creator A5039490929 @default.
- W3196556489 creator A5073782396 @default.
- W3196556489 creator A5075329432 @default.
- W3196556489 date "2021-09-03" @default.
- W3196556489 modified "2023-10-13" @default.
- W3196556489 title "Mechanics of microtubule organizing center clustering and spindle positioning in budding yeast <i>Cryptococcus neoformans</i>" @default.
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