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- W3196557582 abstract "The bacterial genus Klebsiella includes the closely related species K . michiganensis , K . oxytoca and K . pneumoniae , which are capable of causing severe disease in humans. In this report we describe the isolation, genomic and functional characterisation of the lytic bacteriophage KMI8 specific for K . michiganensis . KMI8 belongs to the family Drexlerviridae , and has a novel genome which shares very little homology (71.89% identity over a query cover of only 8%) with that of its closest related bacteriophages (Klebsiella bacteriophage LF20 (MW417503.1); Klebsiella bacteriophage 066039 (MW042802.1). KMI8, which possess a putative endosialidase (depolymerase) enzyme, was shown to be capable of degrading mono-biofilms of a strain of K . michiganensis that carried the polysaccharide capsule KL70 locus. This is the first report of a lytic bacteriophage for K . michiganensis , which is capable of breaking down a biofilm of this species." @default.
- W3196557582 created "2021-09-13" @default.
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- W3196557582 date "2021-09-07" @default.
- W3196557582 modified "2023-09-27" @default.
- W3196557582 title "Novel Drexlerviridae bacteriophage KMI8 with specific lytic activity against Klebsiella michiganensis and its biofilms" @default.
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- W3196557582 doi "https://doi.org/10.1371/journal.pone.0257102" @default.
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