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- W3196558518 abstract "Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed and other databases, the present review aims to extricate the mechanisms by which DOK2 acts on cancer, thereby identifying more reliable and effective therapeutic targets to promote enhanced methods of cancer prevention and treatment. The review focuses on the role of DOK2 in multiple tumor types in the lungs, intestines, liver, and breast. Additionally, we discuss the potential mechanisms of action of DOK2 and the downstream consequences via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways." @default.
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- W3196558518 date "2021-09-10" @default.
- W3196558518 modified "2023-10-01" @default.
- W3196558518 title "Introduction to DOK2 and its potential role in cancer." @default.
- W3196558518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34505522" @default.
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