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- W3196559503 abstract "Current cancer screening recommendations are based in part on estimated cancer risk, because cancer risk in the screened population affects the performance characteristics of the screening test—the higher the risk, the higher the positive predictive value of a screening test. Cancer results from a series of genetic or epigenetic changes that allows poorly controlled cell proliferation and invasion of normal tissue. Tumor suppressor genes are directly involved in cell growth and differentiation. Genetically inherited traits may be transmitted through Mendelian inheritance (e.g., autosomal-dominant, -recessive, or -codominant trait; X-linked trait) or non-Mendelian inheritance (e.g., uniparental disomy; expansion of trinucleotide repeats). Genetic segregation analysis is a statistical modeling approach to teasing out the effect of genes and shared environment. Genetics applications in health care are only going to increase; new genes are being discovered every day." @default.
- W3196559503 created "2021-09-13" @default.
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- W3196559503 date "2021-08-31" @default.
- W3196559503 modified "2023-09-24" @default.
- W3196559503 title "Genetic Inheritance of Cancer Risk: Applications to Cancer Screening" @default.
- W3196559503 doi "https://doi.org/10.1201/9780429179587-26" @default.
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