Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196568928> ?p ?o ?g. }
- W3196568928 endingPage "887" @default.
- W3196568928 startingPage "887" @default.
- W3196568928 abstract "Environmental hypoxia and hypoxia-induced signalling in the gut influence inflammatory bowel disease pathogenesis, however data is limited to colitis. Hence, we investigated the effect of environmental hypoxia and immune cell-specific deletion of oxygen sensor prolyl hydroxylase (PHD) 1 in a Crohn’s like ileitis mouse model. Therefore, 5-week-old C57/BL6 TNF∆ARE/+ mice and wildtype (WT) littermates were housed in normoxia (21% O2) or hypoxia (8% O2) for 10 weeks. Systemic inflammation was assessed by haematology. Distal ileal hypoxia was evaluated by pimonidazole staining. The ileitis degree was scored on histology, characterized via qPCR and validated in haematopoietic Phd1-deficient TNF∆ARE/+ mice. Our results demonstrated that hypoxia did not impact body weight evolution in WT and TNF∆ARE/+ mice. Hypoxia increased red blood cell count, haemoglobin, haematocrit and increased pimonidazole intensity in the ileum. Interestingly, hypoxia evoked an increase in circulatory monocytes, ileal mononuclear phagocytes and proinflammatory cytokine expression in WT mice. Despite these alterations, no histological or ileal gene expression differences could be identified between TNF∆ARE/+ mice housed in hypoxia versus normoxia nor between haematopoietic Phd1-deficient TNF∆ARE/+ and their WT counterparts. Therefore, we demonstrated for the first time that long-term environmental hypoxia or haematopoietic Phd1-deletion does not impact experimental ileitis development." @default.
- W3196568928 created "2021-09-13" @default.
- W3196568928 creator A5022969927 @default.
- W3196568928 creator A5045858994 @default.
- W3196568928 creator A5063293794 @default.
- W3196568928 creator A5067791240 @default.
- W3196568928 creator A5077220554 @default.
- W3196568928 date "2021-09-08" @default.
- W3196568928 modified "2023-09-23" @default.
- W3196568928 title "Long-Term Environmental Hypoxia Exposure and Haematopoietic Prolyl Hydroxylase-1 Deletion Do Not Impact Experimental Crohn’s Like Ileitis" @default.
- W3196568928 cites W1545762702 @default.
- W3196568928 cites W1882298650 @default.
- W3196568928 cites W1955975181 @default.
- W3196568928 cites W1970971661 @default.
- W3196568928 cites W2002394482 @default.
- W3196568928 cites W2004751481 @default.
- W3196568928 cites W2005539293 @default.
- W3196568928 cites W2014752822 @default.
- W3196568928 cites W2017575850 @default.
- W3196568928 cites W2032360189 @default.
- W3196568928 cites W2048007675 @default.
- W3196568928 cites W2056425530 @default.
- W3196568928 cites W2063118013 @default.
- W3196568928 cites W2074372531 @default.
- W3196568928 cites W2078683157 @default.
- W3196568928 cites W2088826436 @default.
- W3196568928 cites W2098087741 @default.
- W3196568928 cites W2103279818 @default.
- W3196568928 cites W2105230781 @default.
- W3196568928 cites W2106925175 @default.
- W3196568928 cites W2108852926 @default.
- W3196568928 cites W2114575027 @default.
- W3196568928 cites W2117972978 @default.
- W3196568928 cites W2139617200 @default.
- W3196568928 cites W2155914783 @default.
- W3196568928 cites W2170159157 @default.
- W3196568928 cites W2260797833 @default.
- W3196568928 cites W2306462975 @default.
- W3196568928 cites W2344484069 @default.
- W3196568928 cites W2411282866 @default.
- W3196568928 cites W2544622716 @default.
- W3196568928 cites W2561617930 @default.
- W3196568928 cites W2565303118 @default.
- W3196568928 cites W2586419526 @default.
- W3196568928 cites W2589709928 @default.
- W3196568928 cites W2735882751 @default.
- W3196568928 cites W2751237807 @default.
- W3196568928 cites W2780809440 @default.
- W3196568928 cites W2890037650 @default.
- W3196568928 cites W2975440312 @default.
- W3196568928 cites W3005499493 @default.
- W3196568928 cites W3030295536 @default.
- W3196568928 cites W3039338741 @default.
- W3196568928 cites W3045732747 @default.
- W3196568928 cites W3157159493 @default.
- W3196568928 cites W4234288885 @default.
- W3196568928 doi "https://doi.org/10.3390/biology10090887" @default.
- W3196568928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8464968" @default.
- W3196568928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34571764" @default.
- W3196568928 hasPublicationYear "2021" @default.
- W3196568928 type Work @default.
- W3196568928 sameAs 3196568928 @default.
- W3196568928 citedByCount "2" @default.
- W3196568928 countsByYear W31965689282023 @default.
- W3196568928 crossrefType "journal-article" @default.
- W3196568928 hasAuthorship W3196568928A5022969927 @default.
- W3196568928 hasAuthorship W3196568928A5045858994 @default.
- W3196568928 hasAuthorship W3196568928A5063293794 @default.
- W3196568928 hasAuthorship W3196568928A5067791240 @default.
- W3196568928 hasAuthorship W3196568928A5077220554 @default.
- W3196568928 hasBestOaLocation W31965689281 @default.
- W3196568928 hasConcept C109159458 @default.
- W3196568928 hasConcept C126322002 @default.
- W3196568928 hasConcept C134018914 @default.
- W3196568928 hasConcept C178790620 @default.
- W3196568928 hasConcept C185592680 @default.
- W3196568928 hasConcept C203014093 @default.
- W3196568928 hasConcept C2777226302 @default.
- W3196568928 hasConcept C2778248108 @default.
- W3196568928 hasConcept C2779134260 @default.
- W3196568928 hasConcept C2779280984 @default.
- W3196568928 hasConcept C2779703530 @default.
- W3196568928 hasConcept C2780941987 @default.
- W3196568928 hasConcept C28328180 @default.
- W3196568928 hasConcept C540031477 @default.
- W3196568928 hasConcept C54355233 @default.
- W3196568928 hasConcept C71924100 @default.
- W3196568928 hasConcept C7836513 @default.
- W3196568928 hasConcept C86803240 @default.
- W3196568928 hasConceptScore W3196568928C109159458 @default.
- W3196568928 hasConceptScore W3196568928C126322002 @default.
- W3196568928 hasConceptScore W3196568928C134018914 @default.
- W3196568928 hasConceptScore W3196568928C178790620 @default.
- W3196568928 hasConceptScore W3196568928C185592680 @default.
- W3196568928 hasConceptScore W3196568928C203014093 @default.
- W3196568928 hasConceptScore W3196568928C2777226302 @default.
- W3196568928 hasConceptScore W3196568928C2778248108 @default.
- W3196568928 hasConceptScore W3196568928C2779134260 @default.