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• W3196574558 abstract "Abstract Running exercise has been shown to relieve symptoms of depression, but the mechanisms underlying the antidepressant effects are unclear. Microglia and concomitant dysregulated neuroinflammation play a pivotal role in the pathogenesis of depression. However, the effects of running exercise on hippocampal neuroinflammation and the number and activation of microglia in depression have not been studied. In this study, rats were subjected to chronic unpredictable stress (CUS) for 5 weeks followed by treadmill running for 6 weeks. The depressive-like symptoms of the rats were assessed with a sucrose preference test (SPT). Immunohistochemistry and stereology were performed to quantify the total number of ionized calcium-binding adapter molecule 1 (Iba1) + microglia, and immunofluorescence was used to quantify the density of Iba1 + /cluster of differentiation 68 (CD68) + in subregions of the hippocampus. The levels of proinflammatory cytokines in the hippocampus were measured by qRT-PCR and ELISA. The results showed that running exercise reversed the decreased sucrose preference of rats with CUS-induced depression. In addition, CUS increased the number of hippocampal microglia and microglial activation in rats, but running exercise attenuated the CUS-induced increases in the number of microglia in the hippocampus and microglial activation in the dentate gyrus (DG) of the hippocampus. Furthermore, CUS significantly increased the hippocampal levels of inflammatory factors, and the increases in inflammatory factors in the hippocampus were suppressed by running exercise. These results suggest that the antidepressant effects of exercise may be mediated by reducing the number of microglia and inhibiting microglial activation and neuroinflammation in the hippocampus." @default.
• W3196574558 created "2021-09-13" @default.
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• W3196574558 date "2021-09-06" @default.
• W3196574558 modified "2023-10-15" @default.
• W3196574558 title "Beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats" @default.
• W3196574558 cites W1485848540 @default.
• W3196574558 cites W1945917319 @default.
• W3196574558 cites W1968019821 @default.
• W3196574558 cites W1972846275 @default.
• W3196574558 cites W1974206938 @default.
• W3196574558 cites W1984103995 @default.
• W3196574558 cites W1984118082 @default.
• W3196574558 cites W1990151307 @default.
• W3196574558 cites W1990168531 @default.
• W3196574558 cites W1991203692 @default.
• W3196574558 cites W1996454121 @default.
• W3196574558 cites W1999494818 @default.
• W3196574558 cites W2012930576 @default.
• W3196574558 cites W2021551531 @default.
• W3196574558 cites W2027467386 @default.
• W3196574558 cites W2030804735 @default.
• W3196574558 cites W2034696716 @default.
• W3196574558 cites W2044115042 @default.
• W3196574558 cites W2047570180 @default.
• W3196574558 cites W2048696229 @default.
• W3196574558 cites W2049361817 @default.
• W3196574558 cites W2051359369 @default.
• W3196574558 cites W2061809825 @default.
• W3196574558 cites W2087146795 @default.
• W3196574558 cites W2097572674 @default.
• W3196574558 cites W2100143444 @default.
• W3196574558 cites W2101221908 @default.
• W3196574558 cites W2104205224 @default.
• W3196574558 cites W2120417084 @default.
• W3196574558 cites W2127854743 @default.
• W3196574558 cites W2131016140 @default.
• W3196574558 cites W2132156834 @default.
• W3196574558 cites W2148764339 @default.
• W3196574558 cites W2152958471 @default.
• W3196574558 cites W2155173051 @default.
• W3196574558 cites W2155686640 @default.
• W3196574558 cites W2201607793 @default.
• W3196574558 cites W2206568798 @default.
• W3196574558 cites W2206933179 @default.
• W3196574558 cites W2259912978 @default.
• W3196574558 cites W2297925470 @default.
• W3196574558 cites W2339162166 @default.
• W3196574558 cites W2416643466 @default.
• W3196574558 cites W2513446130 @default.
• W3196574558 cites W2519464905 @default.
• W3196574558 cites W2527763513 @default.
• W3196574558 cites W2585086069 @default.
• W3196574558 cites W2605980658 @default.
• W3196574558 cites W2606918206 @default.
• W3196574558 cites W2614586381 @default.
• W3196574558 cites W2730743637 @default.
• W3196574558 cites W2750456260 @default.
• W3196574558 cites W2752411745 @default.
• W3196574558 cites W2763705877 @default.
• W3196574558 cites W2766280419 @default.
• W3196574558 cites W2768488673 @default.
• W3196574558 cites W2769175115 @default.
• W3196574558 cites W2787368117 @default.
• W3196574558 cites W2793809687 @default.
• W3196574558 cites W2807669085 @default.
• W3196574558 cites W2865698779 @default.
• W3196574558 cites W2883373399 @default.
• W3196574558 cites W2883717630 @default.
• W3196574558 cites W2898692573 @default.
• W3196574558 cites W2903002361 @default.
• W3196574558 cites W2912654919 @default.
• W3196574558 cites W2914443465 @default.
• W3196574558 cites W2918696465 @default.
• W3196574558 cites W2933242754 @default.
• W3196574558 cites W2952070206 @default.
• W3196574558 cites W2952866042 @default.
• W3196574558 cites W2964576622 @default.
• W3196574558 cites W2978644324 @default.
• W3196574558 cites W2989724902 @default.
• W3196574558 cites W3012333759 @default.
• W3196574558 cites W3018259677 @default.
• W3196574558 cites W4210981518 @default.
• W3196574558 cites W4235277671 @default.
• W3196574558 doi "https://doi.org/10.1038/s41398-021-01571-9" @default.
• W3196574558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8421357" @default.
• W3196574558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34489395" @default.
• W3196574558 hasPublicationYear "2021" @default.

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