Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196577616> ?p ?o ?g. }
- W3196577616 endingPage "7601" @default.
- W3196577616 startingPage "7595" @default.
- W3196577616 abstract "Staphylococci bind to the blood protein von Willebrand Factor (vWF), thereby causing endovascular infections. Whether and how this interaction occurs with the medically important pathogen Staphylococcus epidermidis is unknown. Using single-molecule experiments, we demonstrate that the S. epidermidis protein Aap binds vWF via an ultrastrong force, ∼3 nN, the strongest noncovalent biological bond ever reported, and we show that this interaction is activated by tensile loading, suggesting a catch-bond behavior. Aap-vWF binding involves exclusively the A1 domain of vWF but requires both the A and B domains of Aap, as revealed by inhibition assays using specific monoclonal antibodies. Collectively, our results point to a mechanism where force-induced unfolding of the B repeats activates the A domain of Aap, shifting it from a weak- to a strong-binding state, which then engages into an ultrastrong interaction with vWF A1. This shear-dependent function of Aap offers promise for innovative antistaphylococcal therapies." @default.
- W3196577616 created "2021-09-13" @default.
- W3196577616 creator A5017448394 @default.
- W3196577616 creator A5018841163 @default.
- W3196577616 creator A5027906712 @default.
- W3196577616 creator A5066628190 @default.
- W3196577616 creator A5074636544 @default.
- W3196577616 date "2021-09-01" @default.
- W3196577616 modified "2023-10-16" @default.
- W3196577616 title "AFM Identifies a Protein Complex Involved in Pathogen Adhesion Which Ruptures at Three Nanonewtons" @default.
- W3196577616 cites W1534508763 @default.
- W3196577616 cites W1944741919 @default.
- W3196577616 cites W1952375807 @default.
- W3196577616 cites W1974004204 @default.
- W3196577616 cites W1986838507 @default.
- W3196577616 cites W1998596396 @default.
- W3196577616 cites W2002866097 @default.
- W3196577616 cites W2006070959 @default.
- W3196577616 cites W2033136871 @default.
- W3196577616 cites W2034704186 @default.
- W3196577616 cites W2037170319 @default.
- W3196577616 cites W2051369945 @default.
- W3196577616 cites W2058912578 @default.
- W3196577616 cites W2067993441 @default.
- W3196577616 cites W2073486093 @default.
- W3196577616 cites W2088280521 @default.
- W3196577616 cites W2105062239 @default.
- W3196577616 cites W2113664933 @default.
- W3196577616 cites W2122486748 @default.
- W3196577616 cites W2128769815 @default.
- W3196577616 cites W2129977314 @default.
- W3196577616 cites W2132209544 @default.
- W3196577616 cites W2133889107 @default.
- W3196577616 cites W2137827663 @default.
- W3196577616 cites W2141477555 @default.
- W3196577616 cites W2151187602 @default.
- W3196577616 cites W2152881502 @default.
- W3196577616 cites W2155708268 @default.
- W3196577616 cites W2157346752 @default.
- W3196577616 cites W2158977162 @default.
- W3196577616 cites W2163632114 @default.
- W3196577616 cites W2176206796 @default.
- W3196577616 cites W2255738826 @default.
- W3196577616 cites W2527625861 @default.
- W3196577616 cites W2586130843 @default.
- W3196577616 cites W2738955774 @default.
- W3196577616 cites W2769142460 @default.
- W3196577616 cites W2794818206 @default.
- W3196577616 cites W2795311680 @default.
- W3196577616 cites W2805149954 @default.
- W3196577616 cites W2808224448 @default.
- W3196577616 cites W2970276425 @default.
- W3196577616 cites W2990782246 @default.
- W3196577616 cites W3005567745 @default.
- W3196577616 cites W3008572089 @default.
- W3196577616 cites W3046123161 @default.
- W3196577616 cites W3152953399 @default.
- W3196577616 cites W4235666283 @default.
- W3196577616 cites W3083524321 @default.
- W3196577616 doi "https://doi.org/10.1021/acs.nanolett.1c02105" @default.
- W3196577616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34469164" @default.
- W3196577616 hasPublicationYear "2021" @default.
- W3196577616 type Work @default.
- W3196577616 sameAs 3196577616 @default.
- W3196577616 citedByCount "6" @default.
- W3196577616 countsByYear W31965776162022 @default.
- W3196577616 countsByYear W31965776162023 @default.
- W3196577616 crossrefType "journal-article" @default.
- W3196577616 hasAuthorship W3196577616A5017448394 @default.
- W3196577616 hasAuthorship W3196577616A5018841163 @default.
- W3196577616 hasAuthorship W3196577616A5027906712 @default.
- W3196577616 hasAuthorship W3196577616A5066628190 @default.
- W3196577616 hasAuthorship W3196577616A5074636544 @default.
- W3196577616 hasConcept C107824862 @default.
- W3196577616 hasConcept C12554922 @default.
- W3196577616 hasConcept C159654299 @default.
- W3196577616 hasConcept C178790620 @default.
- W3196577616 hasConcept C185592680 @default.
- W3196577616 hasConcept C203014093 @default.
- W3196577616 hasConcept C25166345 @default.
- W3196577616 hasConcept C2776460866 @default.
- W3196577616 hasConcept C2777949923 @default.
- W3196577616 hasConcept C2779000548 @default.
- W3196577616 hasConcept C2779394231 @default.
- W3196577616 hasConcept C2779489039 @default.
- W3196577616 hasConcept C51639874 @default.
- W3196577616 hasConcept C523546767 @default.
- W3196577616 hasConcept C542903549 @default.
- W3196577616 hasConcept C54355233 @default.
- W3196577616 hasConcept C55493867 @default.
- W3196577616 hasConcept C84416704 @default.
- W3196577616 hasConcept C85789140 @default.
- W3196577616 hasConcept C86803240 @default.
- W3196577616 hasConcept C89423630 @default.
- W3196577616 hasConcept C89560881 @default.
- W3196577616 hasConcept C95444343 @default.
- W3196577616 hasConceptScore W3196577616C107824862 @default.
- W3196577616 hasConceptScore W3196577616C12554922 @default.