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- W3196642910 abstract "Numerous nucleic acid sensor agonists are being trialed for use in cancer immunotherapy, with TLR and STING agonists among the most studied. When administered systemically, however, these small-molecule agonists often have systemic side-effects and are cleared before reaching their target. In this thesis, we explored two approaches to this problem. First, we developed a pH-responsive nanoparticle delivery system that improved the pharmacokinetics of the TLR7 agonist resiquimod. This enhanced local immune activation in mice while reducing systemic exposure, thus offering a promising platform for adjuvant therapies and cancer vaccines. Second, we assessed combinations of agonists with regard to their potency in enhancing DC activation and their impact on cytotoxic T-cell responses. We showed that while the combination of TLR and STING agonists efficiently and synergistically upregulated DC activation, it also upregulated tolerogenic and apoptosis-inducing factors, causing rapid death in co-cultured cytotoxic T cells. The selection of agonists thus requires careful evaluation." @default.
- W3196642910 created "2021-09-13" @default.
- W3196642910 creator A5052884613 @default.
- W3196642910 date "2021-01-01" @default.
- W3196642910 modified "2023-09-27" @default.
- W3196642910 title "Potential and Challenges in Improving Cancer Immunotherapy with Agonists for Nucleic Acid Sensors" @default.
- W3196642910 doi "https://doi.org/10.13097/archive-ouverte/unige:154512" @default.
- W3196642910 hasPublicationYear "2021" @default.
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