FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196670690> ?p ?o ?g. }

• W3196670690 abstract "Leishmania donovani, the causative agent of visceral leishmaniasis, infects and resides within tissue macrophage cells of the mammalian host. It is not clear how the parasite infected cells cross-talk with the non-infected cells in the infection niche to regulate the infection process. Interestingly, miRNAs, the regulatory small RNAs of the host, could get trafficked into and out of infected cells as part of extracellular vesicles to ensure exchange of the epigenetic signals and can regulate the expression of their target genes in both donor and recipient cells. Leishmania, for its survival in host macrophage, adopts a dual strategy to regulate the intercellular transport of host miRNAs. The parasite, by preventing mitochondrial function of the host cells, restricts the entry of liver cell derived miR-122 containing extracellular vesicles in infected macrophage to curtail the inflammatory response by miR-122. The parasite reciprocally upregulates the extracellular export of anti-inflammatory miR-146a from the infected cells. The exported miR-146a restricts miR-122 production in liver cells and polarizes neighbouring naïve macrophages to the M2 state by targeting RNA Binder protein HuR." @default.
• W3196670690 created "2021-09-13" @default.
• W3196670690 creator A5001541572 @default.
• W3196670690 creator A5040884138 @default.
• W3196670690 creator A5041640117 @default.
• W3196670690 creator A5046581323 @default.
• W3196670690 creator A5064692749 @default.
• W3196670690 creator A5083849508 @default.
• W3196670690 creator A5088227251 @default.
• W3196670690 creator A5088290143 @default.
• W3196670690 date "2021-09-07" @default.
• W3196670690 modified "2023-09-27" @default.
• W3196670690 title "Leishmania Hijacks microRNA Import-Export Machinery of Infected Macrophage and Survives by Cross-Communicating Host miR-146a to Subjugate HuR and miR-122 in Neighbouring cells" @default.
• W3196670690 cites W1567625470 @default.
• W3196670690 cites W1762620449 @default.
• W3196670690 cites W1973573989 @default.
• W3196670690 cites W1995612706 @default.
• W3196670690 cites W1996649087 @default.
• W3196670690 cites W2018969070 @default.
• W3196670690 cites W2037953495 @default.
• W3196670690 cites W2054630268 @default.
• W3196670690 cites W2062991952 @default.
• W3196670690 cites W2067442540 @default.
• W3196670690 cites W2071216600 @default.
• W3196670690 cites W2083942660 @default.
• W3196670690 cites W2097617110 @default.
• W3196670690 cites W2100692480 @default.
• W3196670690 cites W2102397711 @default.
• W3196670690 cites W2102517059 @default.
• W3196670690 cites W2105950197 @default.
• W3196670690 cites W2113546559 @default.
• W3196670690 cites W2153690671 @default.
• W3196670690 cites W2159714738 @default.
• W3196670690 cites W2160231321 @default.
• W3196670690 cites W2164840475 @default.
• W3196670690 cites W2168350246 @default.
• W3196670690 cites W2186123618 @default.
• W3196670690 cites W2264436887 @default.
• W3196670690 cites W2302808986 @default.
• W3196670690 cites W2464549086 @default.
• W3196670690 cites W259769697 @default.
• W3196670690 cites W2617126712 @default.
• W3196670690 cites W2710560069 @default.
• W3196670690 cites W2754703278 @default.
• W3196670690 cites W2755613395 @default.
• W3196670690 cites W2761641189 @default.
• W3196670690 cites W2792221349 @default.
• W3196670690 cites W2910704006 @default.
• W3196670690 cites W2918166238 @default.
• W3196670690 cites W2937061963 @default.
• W3196670690 cites W2946003276 @default.
• W3196670690 cites W3004240850 @default.
• W3196670690 cites W3005086862 @default.
• W3196670690 cites W3005104290 @default.
• W3196670690 cites W3006566616 @default.
• W3196670690 cites W3014412035 @default.
• W3196670690 cites W3033192367 @default.
• W3196670690 cites W3081168685 @default.
• W3196670690 cites W3095426407 @default.
• W3196670690 cites W3130089727 @default.
• W3196670690 cites W3134111803 @default.
• W3196670690 cites W3145384825 @default.
• W3196670690 cites W3184695310 @default.
• W3196670690 doi "https://doi.org/10.1101/2021.09.06.459146" @default.
• W3196670690 hasPublicationYear "2021" @default.
• W3196670690 type Work @default.
• W3196670690 sameAs 3196670690 @default.
• W3196670690 citedByCount "0" @default.
• W3196670690 crossrefType "posted-content" @default.
• W3196670690 hasAuthorship W3196670690A5001541572 @default.
• W3196670690 hasAuthorship W3196670690A5040884138 @default.
• W3196670690 hasAuthorship W3196670690A5041640117 @default.
• W3196670690 hasAuthorship W3196670690A5046581323 @default.
• W3196670690 hasAuthorship W3196670690A5064692749 @default.
• W3196670690 hasAuthorship W3196670690A5083849508 @default.
• W3196670690 hasAuthorship W3196670690A5088227251 @default.
• W3196670690 hasAuthorship W3196670690A5088290143 @default.
• W3196670690 hasBestOaLocation W31966706901 @default.
• W3196670690 hasConcept C104317684 @default.
• W3196670690 hasConcept C126831891 @default.
• W3196670690 hasConcept C136764020 @default.
• W3196670690 hasConcept C145059251 @default.
• W3196670690 hasConcept C153726182 @default.
• W3196670690 hasConcept C202751555 @default.
• W3196670690 hasConcept C203014093 @default.
• W3196670690 hasConcept C2776555147 @default.
• W3196670690 hasConcept C2778689377 @default.
• W3196670690 hasConcept C2779244956 @default.
• W3196670690 hasConcept C2781092759 @default.
• W3196670690 hasConcept C2781333301 @default.
• W3196670690 hasConcept C28406088 @default.
• W3196670690 hasConcept C41008148 @default.
• W3196670690 hasConcept C41091548 @default.
• W3196670690 hasConcept C54355233 @default.
• W3196670690 hasConcept C71928629 @default.
• W3196670690 hasConcept C79879829 @default.
• W3196670690 hasConcept C86803240 @default.
• W3196670690 hasConcept C95444343 @default.
• W3196670690 hasConceptScore W3196670690C104317684 @default.
• W3196670690 hasConceptScore W3196670690C126831891 @default.

• next