FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196671889> ?p ?o ?g. }

• W3196671889 endingPage "2922" @default.
• W3196671889 startingPage "2922" @default.
• W3196671889 abstract "Although significant actions have been taken towards the utilization of poly(vinyl alcohol) (PVA) in the preparation of drug amorphous solid dispersions (ASDs) using fusion-based techniques (such as melt-quench cooling and hot-melt extrusion), several drawbacks regarding its rather high melting temperature and its thermal degradation profile make the use of the polymer extremely challenging. This is especially important when the active pharmaceutical ingredient (API) has a lower melting temperature (than PVA) or when it is thermally labile. In this vein, a previous study showed that newly synthesized polyester-based plasticizers may improve the processability and the thermal properties of PVA. However, the effects of such polyester-based plasticizers on the drug’s physicochemical and pharmaco-technical properties are yet unknown. Hence, the aim of the present study is to extend our previous findings and evaluate the use of poly(propylene succinate) (PPSu, i.e., the most promising plasticizer in regard to PVA) in the preparation of drug-loaded PVA-based ASDs. Dronedarone (DRN), a poorly water-soluble API, was selected as a model drug, and drug ASDs (using either neat PVA or PVA-PPSu) were prepared using the melt-mixing/quench cooling approach at low melting temperatures (i.e., 170 °C). DSC and pXRD analysis showed that a portion of the API remained crystalline in the ASDs prepared only with the use of neat PVA, while the samples having PPSu as a plasticizer were completely amorphous. Further evaluation with ATR-FTIR spectroscopy revealed the formation of significant intermolecular interactions between the API and the PVA-PPSu matrix, which could explain the system’s physical stability during storage. Finally, dissolution studies, conducted under nonsink conditions, revealed that the use of PVA-PPSu is able to maintain DRN’s sustained supersaturation for up to 8 h." @default.
• W3196671889 created "2021-09-13" @default.
• W3196671889 creator A5004591893 @default.
• W3196671889 creator A5008186688 @default.
• W3196671889 creator A5017930088 @default.
• W3196671889 creator A5063815618 @default.
• W3196671889 creator A5066787200 @default.
• W3196671889 date "2021-08-30" @default.
• W3196671889 modified "2023-10-18" @default.
• W3196671889 title "Drug Amorphous Solid Dispersions Based on Poly(vinyl Alcohol): Evaluating the Effect of Poly(propylene Succinate) as Plasticizer" @default.
• W3196671889 cites W1269781246 @default.
• W3196671889 cites W1557916166 @default.
• W3196671889 cites W1972954499 @default.
• W3196671889 cites W1979934754 @default.
• W3196671889 cites W1988900293 @default.
• W3196671889 cites W1989461604 @default.
• W3196671889 cites W1997895087 @default.
• W3196671889 cites W2001533174 @default.
• W3196671889 cites W2002393850 @default.
• W3196671889 cites W2002719464 @default.
• W3196671889 cites W2013841303 @default.
• W3196671889 cites W2026884428 @default.
• W3196671889 cites W2030670872 @default.
• W3196671889 cites W2032268755 @default.
• W3196671889 cites W2036679287 @default.
• W3196671889 cites W2058788705 @default.
• W3196671889 cites W2060664647 @default.
• W3196671889 cites W2156313587 @default.
• W3196671889 cites W2158416204 @default.
• W3196671889 cites W2161696103 @default.
• W3196671889 cites W2190842719 @default.
• W3196671889 cites W2243158166 @default.
• W3196671889 cites W2253675932 @default.
• W3196671889 cites W2269570064 @default.
• W3196671889 cites W2318229433 @default.
• W3196671889 cites W2320175401 @default.
• W3196671889 cites W2600733912 @default.
• W3196671889 cites W2755854372 @default.
• W3196671889 cites W2781569741 @default.
• W3196671889 cites W2782273856 @default.
• W3196671889 cites W2790000829 @default.
• W3196671889 cites W2797790446 @default.
• W3196671889 cites W2885356025 @default.
• W3196671889 cites W2898464641 @default.
• W3196671889 cites W2900665806 @default.
• W3196671889 cites W2917574647 @default.
• W3196671889 cites W2945466894 @default.
• W3196671889 cites W2951031181 @default.
• W3196671889 cites W2966492969 @default.
• W3196671889 cites W2985253493 @default.
• W3196671889 cites W2995699906 @default.
• W3196671889 cites W2996744211 @default.
• W3196671889 cites W3004570266 @default.
• W3196671889 cites W3033590762 @default.
• W3196671889 cites W3034563477 @default.
• W3196671889 cites W3048277955 @default.
• W3196671889 cites W3086568107 @default.
• W3196671889 cites W3100020754 @default.
• W3196671889 cites W3115007980 @default.
• W3196671889 cites W4206142648 @default.
• W3196671889 cites W4231034305 @default.
• W3196671889 doi "https://doi.org/10.3390/polym13172922" @default.
• W3196671889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8434550" @default.
• W3196671889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34502962" @default.
• W3196671889 hasPublicationYear "2021" @default.
• W3196671889 type Work @default.
• W3196671889 sameAs 3196671889 @default.
• W3196671889 citedByCount "4" @default.
• W3196671889 countsByYear W31966718892022 @default.
• W3196671889 countsByYear W31966718892023 @default.
• W3196671889 crossrefType "journal-article" @default.
• W3196671889 hasAuthorship W3196671889A5004591893 @default.
• W3196671889 hasAuthorship W3196671889A5008186688 @default.
• W3196671889 hasAuthorship W3196671889A5017930088 @default.
• W3196671889 hasAuthorship W3196671889A5063815618 @default.
• W3196671889 hasAuthorship W3196671889A5066787200 @default.
• W3196671889 hasBestOaLocation W31966718891 @default.
• W3196671889 hasConcept C119394753 @default.
• W3196671889 hasConcept C122865956 @default.
• W3196671889 hasConcept C127413603 @default.
• W3196671889 hasConcept C159985019 @default.
• W3196671889 hasConcept C160892712 @default.
• W3196671889 hasConcept C178790620 @default.
• W3196671889 hasConcept C185592680 @default.
• W3196671889 hasConcept C188027245 @default.
• W3196671889 hasConcept C192562407 @default.
• W3196671889 hasConcept C2778551929 @default.
• W3196671889 hasConcept C2780666587 @default.
• W3196671889 hasConcept C42360764 @default.
• W3196671889 hasConcept C521977710 @default.
• W3196671889 hasConcept C56052488 @default.
• W3196671889 hasConcept C58968531 @default.
• W3196671889 hasConceptScore W3196671889C119394753 @default.
• W3196671889 hasConceptScore W3196671889C122865956 @default.
• W3196671889 hasConceptScore W3196671889C127413603 @default.
• W3196671889 hasConceptScore W3196671889C159985019 @default.
• W3196671889 hasConceptScore W3196671889C160892712 @default.
• W3196671889 hasConceptScore W3196671889C178790620 @default.

• next