Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196688504> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3196688504 endingPage "109024" @default.
- W3196688504 startingPage "109024" @default.
- W3196688504 abstract "This study attempted to determine the effect of EphA2 on H2O2-treated lens epithelial cells (SRA01/04) and the underlying mechanisms. MTT assay and flow cytometry were performed to assess cell viability and cell apoptosis. Western blot was carried out to examine the levels of proteins associated with apoptosis and autophagy. Our results revealed that EphA2 significantly elevated the reduced cell viability, and inhibited the increased cell apoptosis in H2O2-treated SRA01/04 cells, along with the significant up-regulated Bcl-2 and down-regulated Cleaved-caspase-3 and Bax protein levels, but which were all abolished by Rapa (autophagy activator). We also found that EphA2 significantly suppressed cell autophagy in H2O2-treated SRA01/04 cells. Additionally, EphA2 significantly up-regulated the protein levels of p-Akt and p-mTOR in H2O2-treated SRA01/04 cells, and the inhibition of Akt by MK-2206 and inhibition of mTOR by Rapa both obviously reversed EphA2-mediated the inhibition of autophagy in H2O2-treated SRA01/04 cells. In summary, these data demonstrated that EphA2 inhibited the apoptosis of SRA01/04 cells by inhibiting autophagy via activating PI3K/Akt/mTOR pathway." @default.
- W3196688504 created "2021-09-13" @default.
- W3196688504 creator A5004310202 @default.
- W3196688504 creator A5011681363 @default.
- W3196688504 creator A5027051642 @default.
- W3196688504 creator A5044484734 @default.
- W3196688504 creator A5044729368 @default.
- W3196688504 creator A5060201311 @default.
- W3196688504 creator A5085399047 @default.
- W3196688504 date "2021-10-01" @default.
- W3196688504 modified "2023-10-16" @default.
- W3196688504 title "EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway" @default.
- W3196688504 cites W1649314838 @default.
- W3196688504 cites W1677174195 @default.
- W3196688504 cites W1967364145 @default.
- W3196688504 cites W1979051854 @default.
- W3196688504 cites W1983104893 @default.
- W3196688504 cites W1987089875 @default.
- W3196688504 cites W1993784744 @default.
- W3196688504 cites W1998007541 @default.
- W3196688504 cites W2014380171 @default.
- W3196688504 cites W2022895299 @default.
- W3196688504 cites W2045946713 @default.
- W3196688504 cites W2089228924 @default.
- W3196688504 cites W2131366598 @default.
- W3196688504 cites W2132464112 @default.
- W3196688504 cites W2797080089 @default.
- W3196688504 cites W2938763520 @default.
- W3196688504 cites W2963163312 @default.
- W3196688504 cites W2973410605 @default.
- W3196688504 cites W2986749851 @default.
- W3196688504 cites W2995359770 @default.
- W3196688504 cites W3011907975 @default.
- W3196688504 cites W3090467772 @default.
- W3196688504 doi "https://doi.org/10.1016/j.abb.2021.109024" @default.
- W3196688504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34487720" @default.
- W3196688504 hasPublicationYear "2021" @default.
- W3196688504 type Work @default.
- W3196688504 sameAs 3196688504 @default.
- W3196688504 citedByCount "6" @default.
- W3196688504 countsByYear W31966885042022 @default.
- W3196688504 countsByYear W31966885042023 @default.
- W3196688504 crossrefType "journal-article" @default.
- W3196688504 hasAuthorship W3196688504A5004310202 @default.
- W3196688504 hasAuthorship W3196688504A5011681363 @default.
- W3196688504 hasAuthorship W3196688504A5027051642 @default.
- W3196688504 hasAuthorship W3196688504A5044484734 @default.
- W3196688504 hasAuthorship W3196688504A5044729368 @default.
- W3196688504 hasAuthorship W3196688504A5060201311 @default.
- W3196688504 hasAuthorship W3196688504A5085399047 @default.
- W3196688504 hasConcept C153911025 @default.
- W3196688504 hasConcept C185592680 @default.
- W3196688504 hasConcept C190283241 @default.
- W3196688504 hasConcept C203522944 @default.
- W3196688504 hasConcept C43060935 @default.
- W3196688504 hasConcept C502942594 @default.
- W3196688504 hasConcept C53227056 @default.
- W3196688504 hasConcept C553184892 @default.
- W3196688504 hasConcept C55493867 @default.
- W3196688504 hasConcept C75217442 @default.
- W3196688504 hasConcept C86554907 @default.
- W3196688504 hasConcept C86803240 @default.
- W3196688504 hasConcept C95444343 @default.
- W3196688504 hasConceptScore W3196688504C153911025 @default.
- W3196688504 hasConceptScore W3196688504C185592680 @default.
- W3196688504 hasConceptScore W3196688504C190283241 @default.
- W3196688504 hasConceptScore W3196688504C203522944 @default.
- W3196688504 hasConceptScore W3196688504C43060935 @default.
- W3196688504 hasConceptScore W3196688504C502942594 @default.
- W3196688504 hasConceptScore W3196688504C53227056 @default.
- W3196688504 hasConceptScore W3196688504C553184892 @default.
- W3196688504 hasConceptScore W3196688504C55493867 @default.
- W3196688504 hasConceptScore W3196688504C75217442 @default.
- W3196688504 hasConceptScore W3196688504C86554907 @default.
- W3196688504 hasConceptScore W3196688504C86803240 @default.
- W3196688504 hasConceptScore W3196688504C95444343 @default.
- W3196688504 hasFunder F4320321001 @default.
- W3196688504 hasLocation W31966885041 @default.
- W3196688504 hasLocation W31966885042 @default.
- W3196688504 hasOpenAccess W3196688504 @default.
- W3196688504 hasPrimaryLocation W31966885041 @default.
- W3196688504 hasRelatedWork W2024933597 @default.
- W3196688504 hasRelatedWork W2066659565 @default.
- W3196688504 hasRelatedWork W2070783513 @default.
- W3196688504 hasRelatedWork W2098584395 @default.
- W3196688504 hasRelatedWork W2422815049 @default.
- W3196688504 hasRelatedWork W2916964185 @default.
- W3196688504 hasRelatedWork W2982360817 @default.
- W3196688504 hasRelatedWork W3116479654 @default.
- W3196688504 hasRelatedWork W3183179750 @default.
- W3196688504 hasRelatedWork W4205189596 @default.
- W3196688504 hasVolume "711" @default.
- W3196688504 isParatext "false" @default.
- W3196688504 isRetracted "false" @default.
- W3196688504 magId "3196688504" @default.
- W3196688504 workType "article" @default.