Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196702900> ?p ?o ?g. }
- W3196702900 endingPage "24274" @default.
- W3196702900 startingPage "24266" @default.
- W3196702900 abstract "We report a simple and rapid saliva-based SARS-CoV-2 antigen test that utilizes a newly developed dimeric DNA aptamer, denoted as DSA1N5, that specifically recognizes the spike proteins of the wildtype virus and its Alpha and Delta variants with dissociation constants of 120, 290 and 480 pM, respectively, and binds pseudotyped lentiviruses expressing the wildtype and alpha trimeric spike proteins with affinity constants of 2.1 pM and 2.3 pM, respectively. To develop a highly sensitive test, DSA1N5 was immobilized onto gold electrodes to produce an electrochemical impedance sensor, which was capable of detecting 1000 viral particles per mL in 1:1 diluted saliva in under 10 min without any further sample processing. Evaluation of 36 positive and 37 negative patient saliva samples produced a clinical sensitivity of 80.5 % and specificity of 100 % and the sensor could detect the wildtype virus as well as the Alpha and Delta variants in the patient samples, which is the first reported rapid test that can detect any emerging variant of SARS-CoV-2." @default.
- W3196702900 created "2021-09-13" @default.
- W3196702900 creator A5000460824 @default.
- W3196702900 creator A5001151712 @default.
- W3196702900 creator A5005353492 @default.
- W3196702900 creator A5005723996 @default.
- W3196702900 creator A5006914372 @default.
- W3196702900 creator A5011533896 @default.
- W3196702900 creator A5030506530 @default.
- W3196702900 creator A5036317618 @default.
- W3196702900 creator A5039010011 @default.
- W3196702900 creator A5052134961 @default.
- W3196702900 creator A5063606749 @default.
- W3196702900 creator A5066625736 @default.
- W3196702900 creator A5068762950 @default.
- W3196702900 creator A5070686308 @default.
- W3196702900 creator A5076241195 @default.
- W3196702900 creator A5078849862 @default.
- W3196702900 creator A5081367802 @default.
- W3196702900 creator A5091719169 @default.
- W3196702900 date "2021-10-04" @default.
- W3196702900 modified "2023-10-13" @default.
- W3196702900 title "High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva" @default.
- W3196702900 cites W1995893035 @default.
- W3196702900 cites W2014909608 @default.
- W3196702900 cites W2035620909 @default.
- W3196702900 cites W2084646413 @default.
- W3196702900 cites W2094417314 @default.
- W3196702900 cites W2097025265 @default.
- W3196702900 cites W2104960492 @default.
- W3196702900 cites W2120172812 @default.
- W3196702900 cites W2141959911 @default.
- W3196702900 cites W2695995371 @default.
- W3196702900 cites W2766983864 @default.
- W3196702900 cites W2888831785 @default.
- W3196702900 cites W2945892097 @default.
- W3196702900 cites W3003777980 @default.
- W3196702900 cites W3006703916 @default.
- W3196702900 cites W3013093478 @default.
- W3196702900 cites W3013186573 @default.
- W3196702900 cites W3015636815 @default.
- W3196702900 cites W3017300461 @default.
- W3196702900 cites W3017334101 @default.
- W3196702900 cites W3020828664 @default.
- W3196702900 cites W3029210427 @default.
- W3196702900 cites W3029765016 @default.
- W3196702900 cites W3039616886 @default.
- W3196702900 cites W3042813589 @default.
- W3196702900 cites W3049142173 @default.
- W3196702900 cites W3080652759 @default.
- W3196702900 cites W3081055927 @default.
- W3196702900 cites W3083130172 @default.
- W3196702900 cites W3089320472 @default.
- W3196702900 cites W3089965698 @default.
- W3196702900 cites W3091281260 @default.
- W3196702900 cites W3092050672 @default.
- W3196702900 cites W3093119363 @default.
- W3196702900 cites W3093249998 @default.
- W3196702900 cites W3093357954 @default.
- W3196702900 cites W3094968263 @default.
- W3196702900 cites W3095349133 @default.
- W3196702900 cites W3096465066 @default.
- W3196702900 cites W3097327172 @default.
- W3196702900 cites W3100524168 @default.
- W3196702900 cites W3108584707 @default.
- W3196702900 cites W3111216988 @default.
- W3196702900 cites W3111570571 @default.
- W3196702900 cites W3113088690 @default.
- W3196702900 cites W3114598451 @default.
- W3196702900 cites W3115577990 @default.
- W3196702900 cites W3118593024 @default.
- W3196702900 cites W3124260803 @default.
- W3196702900 cites W3125585717 @default.
- W3196702900 cites W3127568233 @default.
- W3196702900 cites W3127780670 @default.
- W3196702900 cites W3130076917 @default.
- W3196702900 cites W3130420925 @default.
- W3196702900 cites W3133639725 @default.
- W3196702900 cites W3134432287 @default.
- W3196702900 cites W3134499642 @default.
- W3196702900 cites W3134798193 @default.
- W3196702900 cites W3135005312 @default.
- W3196702900 cites W3135504539 @default.
- W3196702900 cites W3138766497 @default.
- W3196702900 cites W3145809966 @default.
- W3196702900 cites W3157559745 @default.
- W3196702900 cites W3159663293 @default.
- W3196702900 cites W3169503674 @default.
- W3196702900 cites W3170606898 @default.
- W3196702900 cites W3178327715 @default.
- W3196702900 cites W4205413795 @default.
- W3196702900 cites W4205790170 @default.
- W3196702900 cites W4232330064 @default.
- W3196702900 doi "https://doi.org/10.1002/anie.202110819" @default.
- W3196702900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8596624" @default.
- W3196702900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34464491" @default.
- W3196702900 hasPublicationYear "2021" @default.
- W3196702900 type Work @default.