FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196758650> ?p ?o ?g. }

• W3196758650 endingPage "8800" @default.
• W3196758650 startingPage "8790" @default.
• W3196758650 abstract "Social behaviors, including reproductive behaviors, often display sexual dimorphism. Lordosis, the measure of female sexual receptivity, is one of the most apparent sexually dimorphic reproductive behaviors. Lordosis is regulated by estrogen and progesterone (P4) acting within a hypothalamic-limbic circuit, consisting of the arcuate, medial preoptic, and ventromedial nuclei of the hypothalamus. Social cues are integrated into the circuit through the amygdala. The posterodorsal part of the medial amygdala (MeApd) is involved in sexually dimorphic social and reproductive behaviors, and sends projections to hypothalamic neuroendocrine regions. GABA from the MeApd appears to facilitate social behaviors, while glutamate may play the opposite role. To test these hypotheses, adult female vesicular GABA transporter (VGAT)-Cre and vesicular glutamate transporter 2 (VGluT2)-Cre mice were transfected with halorhodopsin (eNpHR)-expressing or channelrhodopsin-expressing adeno-associated viruses (AAVs), respectively, in the MeApd. The lordosis quotient (LQ) was measured following either photoinhibition of VGAT or photoexcitation of VGluT2 neurons, and brains were assessed for c-Fos immunohistochemistry (IHC). Photoinhibition of VGAT neurons in the MeApd decreased LQ, and decreased c-Fos expression within VGAT neurons, within the MeApd as a whole, and within the ventrolateral part of the ventromedial nucleus (VMHvl). Photoexcitation of VGluT2 neurons did not affect LQ, but did increase time spent self-grooming, and increased c-Fos expression within VGluT2 neurons in the MeApd. Neither condition altered c-Fos expression in the medial preoptic nucleus (MPN) or the arcuate nucleus (ARH). These data support a role for MeApd GABA in the facilitation of lordosis. Glutamate from the MeApd does not appear to be directly involved in the lordosis circuit, but appears to direct behavior away from social interactions.SIGNIFICANCE STATEMENT Lordosis, the measure of female sexual receptivity, is a sexually dimorphic behavior regulated within a hypothalamic-limbic circuit. Social cues are integrated through the amygdala, and the posterodorsal part of the medial amygdala (MeApd) is involved in sexually dimorphic social and reproductive behaviors. Photoinhibition of GABAergic neurons in the MeApd inhibited lordosis, while photoactivation of glutamate neurons had no effect on lordosis, but increased self-grooming. These data support a role for MeApd GABA in the facilitation of social behaviors and MeApd glutamate projections in anti-social interactions." @default.
• W3196758650 created "2021-09-13" @default.
• W3196758650 creator A5002071935 @default.
• W3196758650 creator A5029348051 @default.
• W3196758650 creator A5051203411 @default.
• W3196758650 date "2021-09-01" @default.
• W3196758650 modified "2023-09-30" @default.
• W3196758650 title "Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections" @default.
• W3196758650 cites W1505732106 @default.
• W3196758650 cites W1541267199 @default.
• W3196758650 cites W1967489685 @default.
• W3196758650 cites W1993164119 @default.
• W3196758650 cites W1996766802 @default.
• W3196758650 cites W2019314754 @default.
• W3196758650 cites W2024636649 @default.
• W3196758650 cites W2025253585 @default.
• W3196758650 cites W2027061276 @default.
• W3196758650 cites W2028474222 @default.
• W3196758650 cites W2029499654 @default.
• W3196758650 cites W2030986988 @default.
• W3196758650 cites W2031518606 @default.
• W3196758650 cites W2035928623 @default.
• W3196758650 cites W2040672168 @default.
• W3196758650 cites W2050581082 @default.
• W3196758650 cites W2052780399 @default.
• W3196758650 cites W2061072142 @default.
• W3196758650 cites W2061226675 @default.
• W3196758650 cites W2062919524 @default.
• W3196758650 cites W2065254519 @default.
• W3196758650 cites W2070827848 @default.
• W3196758650 cites W2071143997 @default.
• W3196758650 cites W2080056868 @default.
• W3196758650 cites W2084216483 @default.
• W3196758650 cites W2088443095 @default.
• W3196758650 cites W2098277878 @default.
• W3196758650 cites W2099540110 @default.
• W3196758650 cites W2102262129 @default.
• W3196758650 cites W2104235622 @default.
• W3196758650 cites W2123491442 @default.
• W3196758650 cites W2153900484 @default.
• W3196758650 cites W2167541848 @default.
• W3196758650 cites W2503099426 @default.
• W3196758650 cites W2621808436 @default.
• W3196758650 cites W2730450595 @default.
• W3196758650 cites W2756247373 @default.
• W3196758650 cites W2883807507 @default.
• W3196758650 cites W2914152754 @default.
• W3196758650 cites W2935715912 @default.
• W3196758650 cites W2998927464 @default.
• W3196758650 cites W4232573973 @default.
• W3196758650 doi "https://doi.org/10.1523/jneurosci.1103-21.2021" @default.
• W3196758650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8528505" @default.
• W3196758650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34470806" @default.
• W3196758650 hasPublicationYear "2021" @default.
• W3196758650 type Work @default.
• W3196758650 sameAs 3196758650 @default.
• W3196758650 citedByCount "7" @default.
• W3196758650 countsByYear W31967586502022 @default.
• W3196758650 countsByYear W31967586502023 @default.
• W3196758650 crossrefType "journal-article" @default.
• W3196758650 hasAuthorship W3196758650A5002071935 @default.
• W3196758650 hasAuthorship W3196758650A5029348051 @default.
• W3196758650 hasAuthorship W3196758650A5051203411 @default.
• W3196758650 hasBestOaLocation W31967586501 @default.
• W3196758650 hasConcept C126322002 @default.
• W3196758650 hasConcept C134018914 @default.
• W3196758650 hasConcept C15490471 @default.
• W3196758650 hasConcept C169760540 @default.
• W3196758650 hasConcept C170493617 @default.
• W3196758650 hasConcept C2776046087 @default.
• W3196758650 hasConcept C2777003273 @default.
• W3196758650 hasConcept C2777659854 @default.
• W3196758650 hasConcept C2778458369 @default.
• W3196758650 hasConcept C2779144063 @default.
• W3196758650 hasConcept C2779245659 @default.
• W3196758650 hasConcept C61174792 @default.
• W3196758650 hasConcept C71924100 @default.
• W3196758650 hasConcept C86803240 @default.
• W3196758650 hasConceptScore W3196758650C126322002 @default.
• W3196758650 hasConceptScore W3196758650C134018914 @default.
• W3196758650 hasConceptScore W3196758650C15490471 @default.
• W3196758650 hasConceptScore W3196758650C169760540 @default.
• W3196758650 hasConceptScore W3196758650C170493617 @default.
• W3196758650 hasConceptScore W3196758650C2776046087 @default.
• W3196758650 hasConceptScore W3196758650C2777003273 @default.
• W3196758650 hasConceptScore W3196758650C2777659854 @default.
• W3196758650 hasConceptScore W3196758650C2778458369 @default.
• W3196758650 hasConceptScore W3196758650C2779144063 @default.
• W3196758650 hasConceptScore W3196758650C2779245659 @default.
• W3196758650 hasConceptScore W3196758650C61174792 @default.
• W3196758650 hasConceptScore W3196758650C71924100 @default.
• W3196758650 hasConceptScore W3196758650C86803240 @default.
• W3196758650 hasFunder F4320337347 @default.
• W3196758650 hasIssue "42" @default.
• W3196758650 hasLocation W31967586501 @default.
• W3196758650 hasLocation W31967586502 @default.
• W3196758650 hasLocation W31967586503 @default.
• W3196758650 hasOpenAccess W3196758650 @default.

• next