FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196759877> ?p ?o ?g. }

• W3196759877 endingPage "101331" @default.
• W3196759877 startingPage "101331" @default.
• W3196759877 abstract "The cycle of feeding and fasting is fundamental to life and closely coordinated with changes of metabolic programs. During extended starvation, ketogenesis coupled with fatty acid oxidation in the liver supplies ketone bodies to extrahepatic tissues as the major form of fuel. In this study, we demonstrated that PAQR9, a member of the progesterone and adipoQ receptor family, has a regulatory role on hepatic ketogenesis. We analyzed the phenotype of Paqr9-deleted mice. We also used biochemical methods to investigate the interaction of PAQR9 with PPARα and HUWE1, an E3 ubiquitin ligase. The expression of Paqr9 was decreased during fasting partly depending on PPARγ. The overall phenotype of the mice was not altered by Paqr9 deletion under normal chow feeding. However, fasting-induced ketogenesis and fatty acid oxidation were attenuated by Paqr9 deletion. Mechanistically, Paqr9 deletion decreased protein stability of PPARα via enhancing its poly-ubiquitination. PAQR9 competed with HUWE1 for interaction with PPARα, thus preventing ubiquitin-mediated degradation of PPARα. Our study reveals that PAQR9 impacts starvation-mediated metabolic changes in the liver via post-translational regulation of PPARα." @default.
• W3196759877 created "2021-09-13" @default.
• W3196759877 creator A5015673052 @default.
• W3196759877 creator A5036803265 @default.
• W3196759877 creator A5037458498 @default.
• W3196759877 creator A5045204027 @default.
• W3196759877 creator A5071369567 @default.
• W3196759877 creator A5079912108 @default.
• W3196759877 date "2021-11-01" @default.
• W3196759877 modified "2023-10-11" @default.
• W3196759877 title "PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα" @default.
• W3196759877 cites W1503760388 @default.
• W3196759877 cites W1526348057 @default.
• W3196759877 cites W1949573730 @default.
• W3196759877 cites W1975962309 @default.
• W3196759877 cites W1980371754 @default.
• W3196759877 cites W1986666681 @default.
• W3196759877 cites W2012255717 @default.
• W3196759877 cites W2016752484 @default.
• W3196759877 cites W2044152222 @default.
• W3196759877 cites W2057521072 @default.
• W3196759877 cites W2068226015 @default.
• W3196759877 cites W2084312389 @default.
• W3196759877 cites W2087962053 @default.
• W3196759877 cites W2119331212 @default.
• W3196759877 cites W2133465414 @default.
• W3196759877 cites W2139987952 @default.
• W3196759877 cites W2143421197 @default.
• W3196759877 cites W2156696514 @default.
• W3196759877 cites W2158217645 @default.
• W3196759877 cites W2168854431 @default.
• W3196759877 cites W2562858475 @default.
• W3196759877 cites W2566710076 @default.
• W3196759877 cites W2587156779 @default.
• W3196759877 cites W2769632036 @default.
• W3196759877 cites W2783671245 @default.
• W3196759877 cites W3000300632 @default.
• W3196759877 cites W3119647652 @default.
• W3196759877 cites W897053768 @default.
• W3196759877 doi "https://doi.org/10.1016/j.molmet.2021.101331" @default.
• W3196759877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8452888" @default.
• W3196759877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34474167" @default.
• W3196759877 hasPublicationYear "2021" @default.
• W3196759877 type Work @default.
• W3196759877 sameAs 3196759877 @default.
• W3196759877 citedByCount "5" @default.
• W3196759877 countsByYear W31967598772022 @default.
• W3196759877 countsByYear W31967598772023 @default.
• W3196759877 crossrefType "journal-article" @default.
• W3196759877 hasAuthorship W3196759877A5015673052 @default.
• W3196759877 hasAuthorship W3196759877A5036803265 @default.
• W3196759877 hasAuthorship W3196759877A5037458498 @default.
• W3196759877 hasAuthorship W3196759877A5045204027 @default.
• W3196759877 hasAuthorship W3196759877A5071369567 @default.
• W3196759877 hasAuthorship W3196759877A5079912108 @default.
• W3196759877 hasBestOaLocation W31967598771 @default.
• W3196759877 hasConcept C104317684 @default.
• W3196759877 hasConcept C126322002 @default.
• W3196759877 hasConcept C127078168 @default.
• W3196759877 hasConcept C134018914 @default.
• W3196759877 hasConcept C134459356 @default.
• W3196759877 hasConcept C138463869 @default.
• W3196759877 hasConcept C170493617 @default.
• W3196759877 hasConcept C173396325 @default.
• W3196759877 hasConcept C185592680 @default.
• W3196759877 hasConcept C187345961 @default.
• W3196759877 hasConcept C25602115 @default.
• W3196759877 hasConcept C2780606744 @default.
• W3196759877 hasConcept C31532488 @default.
• W3196759877 hasConcept C543025807 @default.
• W3196759877 hasConcept C55493867 @default.
• W3196759877 hasConcept C62231903 @default.
• W3196759877 hasConcept C63932345 @default.
• W3196759877 hasConcept C71924100 @default.
• W3196759877 hasConcept C82714985 @default.
• W3196759877 hasConcept C84693403 @default.
• W3196759877 hasConcept C86339819 @default.
• W3196759877 hasConcept C86803240 @default.
• W3196759877 hasConceptScore W3196759877C104317684 @default.
• W3196759877 hasConceptScore W3196759877C126322002 @default.
• W3196759877 hasConceptScore W3196759877C127078168 @default.
• W3196759877 hasConceptScore W3196759877C134018914 @default.
• W3196759877 hasConceptScore W3196759877C134459356 @default.
• W3196759877 hasConceptScore W3196759877C138463869 @default.
• W3196759877 hasConceptScore W3196759877C170493617 @default.
• W3196759877 hasConceptScore W3196759877C173396325 @default.
• W3196759877 hasConceptScore W3196759877C185592680 @default.
• W3196759877 hasConceptScore W3196759877C187345961 @default.
• W3196759877 hasConceptScore W3196759877C25602115 @default.
• W3196759877 hasConceptScore W3196759877C2780606744 @default.
• W3196759877 hasConceptScore W3196759877C31532488 @default.
• W3196759877 hasConceptScore W3196759877C543025807 @default.
• W3196759877 hasConceptScore W3196759877C55493867 @default.
• W3196759877 hasConceptScore W3196759877C62231903 @default.
• W3196759877 hasConceptScore W3196759877C63932345 @default.
• W3196759877 hasConceptScore W3196759877C71924100 @default.
• W3196759877 hasConceptScore W3196759877C82714985 @default.
• W3196759877 hasConceptScore W3196759877C84693403 @default.

• next