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• W3196820107 abstract "Many studies have shown that the space environment plays a pivotal role in changing the characteristics of conditional pathogens, especially their pathogenicity and virulence. However, Stenotrophomonas maltophilia , a type of conditional pathogen that has shown to a gradual increase in clinical morbidity in recent years, has rarely been reported for its impact in space. In this study, S. maltophilia was exposed to a simulated microgravity (SMG) environment in high-aspect ratio rotating-wall vessel bioreactors for 14days, while the control group was exposed to the same bioreactors in a normal gravity (NG) environment. Then, combined phenotypic, genomic, transcriptomic, and proteomic analyses were conducted to compare the influence of the SMG and NG on S. maltophilia . The results showed that S. maltophilia in simulated microgravity displayed an increased growth rate, enhanced biofilm formation ability, increased swimming motility, and metabolic alterations compared with those of S. maltophilia in normal gravity and the original strain of S. maltophilia . Clusters of Orthologous Groups (COG) annotation analysis indicated that the increased growth rate might be related to the upregulation of differentially expressed genes (DEGs) involved in energy metabolism and conversion, secondary metabolite biosynthesis, transport and catabolism, intracellular trafficking, secretion, and vesicular transport. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that the increased motility might be associated the upregulation of differentially expressed proteins (DEPs) involved in locomotion, localization, biological adhesion, and binding, in accordance with the upregulated DEGs in cell motility according to COG classification, including pilP, pilM, flgE, flgG, and ronN. Additionally, the increased biofilm formation ability might be associated with the upregulation of DEPs involved in biofilm formation, the bacterial secretion system, biological adhesion, and cell adhesion, which were shown to be regulated by the differentially expressed genes (chpB, chpC, rpoN, pilA, pilG, pilH, and pilJ) through the integration of transcriptomic and proteomic analyses. These results suggested that simulated microgravity might increase the level of corresponding functional proteins by upregulating related genes to alter physiological characteristics and modulate growth rate, motility, biofilm formation, and metabolism. In conclusion, this study is the first general analysis of the phenotypic, genomic, transcriptomic, and proteomic changes in S. maltophilia under simulated microgravity and provides some suggestions for future studies of space microbiology." @default.
• W3196820107 created "2021-09-13" @default.
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• W3196820107 date "2021-08-27" @default.
• W3196820107 modified "2023-10-17" @default.
• W3196820107 title "Effects of Simulated Microgravity on the Physiology of Stenotrophomonas maltophilia and Multiomic Analysis" @default.
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• W3196820107 cites W1990178759 @default.
• W3196820107 cites W1994410481 @default.
• W3196820107 cites W1997063081 @default.
• W3196820107 cites W2002083710 @default.
• W3196820107 cites W2005557196 @default.
• W3196820107 cites W2030308486 @default.
• W3196820107 cites W2040731135 @default.
• W3196820107 cites W2051908246 @default.
• W3196820107 cites W2059785315 @default.
• W3196820107 cites W2068846358 @default.
• W3196820107 cites W2075147307 @default.
• W3196820107 cites W2079095790 @default.
• W3196820107 cites W2082467252 @default.
• W3196820107 cites W2082666364 @default.
• W3196820107 cites W2097012953 @default.
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• W3196820107 cites W2107766352 @default.
• W3196820107 cites W2115380923 @default.
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• W3196820107 cites W2279169249 @default.
• W3196820107 cites W2406511101 @default.
• W3196820107 cites W2467701455 @default.
• W3196820107 cites W2474819442 @default.
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• W3196820107 cites W2507933882 @default.
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• W3196820107 cites W2748233709 @default.
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• W3196820107 cites W2901763616 @default.
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• W3196820107 cites W2981445676 @default.
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• W3196820107 doi "https://doi.org/10.3389/fmicb.2021.701265" @default.
• W3196820107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8429793" @default.
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• W3196820107 hasPublicationYear "2021" @default.
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