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• W3196870413 endingPage "101137" @default.
• W3196870413 startingPage "101137" @default.
• W3196870413 abstract "In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase (RNR), the enzyme responsible for biosynthesis of the 2'-deoxynucleotide building blocks of DNA. The metal ion generates an oxidant for an active site cysteine (Cys), yielding a thiyl radical that is necessary for initiation of catalysis in all RNRs. Class I enzymes, widespread in eukaryotes and aerobic microbes, share a common requirement for dioxygen in assembly of the active Cys oxidant and a unique quaternary structure, in which the metallo- or radical-cofactor is found in a separate subunit, β, from the catalytic α subunit. The first class I RNRs, the class Ia enzymes, discovered and characterized more than 30 years ago, were found to use a diiron(III)-tyrosyl-radical Cys oxidant. Although class Ia RNRs have historically served as the model for understanding enzyme mechanism and function, more recently, remarkably diverse bioinorganic and radical cofactors have been discovered in class I RNRs from pathogenic microbes. These enzymes use alternative transition metal ions, such as manganese, or posttranslationally installed tyrosyl radicals for initiation of ribonucleotide reduction. Here we summarize the recent progress in discovery and characterization of novel class I RNR radical-initiating cofactors, their mechanisms of assembly, and how they might function in the context of the active class I holoenzyme complex." @default.
• W3196870413 created "2021-09-13" @default.
• W3196870413 creator A5039065878 @default.
• W3196870413 creator A5039479636 @default.
• W3196870413 date "2021-10-01" @default.
• W3196870413 modified "2023-10-14" @default.
• W3196870413 title "The periodic table of ribonucleotide reductases" @default.
• W3196870413 cites W1491770795 @default.
• W3196870413 cites W1510103500 @default.
• W3196870413 cites W1684735203 @default.
• W3196870413 cites W185850242 @default.
• W3196870413 cites W1968893393 @default.
• W3196870413 cites W1971238892 @default.
• W3196870413 cites W1973844844 @default.
• W3196870413 cites W1974923900 @default.
• W3196870413 cites W1981539002 @default.
• W3196870413 cites W1983901754 @default.
• W3196870413 cites W1986305567 @default.
• W3196870413 cites W1986375296 @default.
• W3196870413 cites W1990551485 @default.
• W3196870413 cites W1998000782 @default.
• W3196870413 cites W1999357474 @default.
• W3196870413 cites W2001053812 @default.
• W3196870413 cites W2008726027 @default.
• W3196870413 cites W2010785482 @default.
• W3196870413 cites W2011455824 @default.
• W3196870413 cites W2011856876 @default.
• W3196870413 cites W2013492423 @default.
• W3196870413 cites W2017256508 @default.
• W3196870413 cites W2019952234 @default.
• W3196870413 cites W2023764313 @default.
• W3196870413 cites W2024610281 @default.
• W3196870413 cites W2030350346 @default.
• W3196870413 cites W2034301317 @default.
• W3196870413 cites W2044669586 @default.
• W3196870413 cites W2045888308 @default.
• W3196870413 cites W2046680152 @default.
• W3196870413 cites W2047167565 @default.
• W3196870413 cites W2050088367 @default.
• W3196870413 cites W2056383496 @default.
• W3196870413 cites W2061047369 @default.
• W3196870413 cites W2062678518 @default.
• W3196870413 cites W2063501752 @default.
• W3196870413 cites W2071884657 @default.
• W3196870413 cites W2073347601 @default.
• W3196870413 cites W2074775358 @default.
• W3196870413 cites W2075939754 @default.
• W3196870413 cites W2080343030 @default.
• W3196870413 cites W2080756776 @default.
• W3196870413 cites W2083816365 @default.
• W3196870413 cites W2087245713 @default.
• W3196870413 cites W2090684905 @default.
• W3196870413 cites W2091603648 @default.
• W3196870413 cites W2092893103 @default.
• W3196870413 cites W2094677489 @default.
• W3196870413 cites W2105199418 @default.
• W3196870413 cites W2113185442 @default.
• W3196870413 cites W2116542858 @default.
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• W3196870413 cites W2131077681 @default.
• W3196870413 cites W2134702221 @default.
• W3196870413 cites W2144631571 @default.
• W3196870413 cites W2148579806 @default.
• W3196870413 cites W2159285197 @default.
• W3196870413 cites W2167456427 @default.
• W3196870413 cites W2171203359 @default.
• W3196870413 cites W2312404231 @default.
• W3196870413 cites W2412762869 @default.
• W3196870413 cites W2434921622 @default.
• W3196870413 cites W2510583362 @default.
• W3196870413 cites W2515522618 @default.
• W3196870413 cites W2575733432 @default.
• W3196870413 cites W2604915006 @default.
• W3196870413 cites W2755131625 @default.
• W3196870413 cites W2796366830 @default.
• W3196870413 cites W2808177665 @default.
• W3196870413 cites W2809675229 @default.
• W3196870413 cites W2886567318 @default.
• W3196870413 cites W2890331430 @default.
• W3196870413 cites W2950109103 @default.
• W3196870413 cites W2967675715 @default.
• W3196870413 cites W2976704092 @default.
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• W3196870413 doi "https://doi.org/10.1016/j.jbc.2021.101137" @default.
• W3196870413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8463856" @default.
• W3196870413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34461093" @default.
• W3196870413 hasPublicationYear "2021" @default.
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