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- W3196882753 abstract "Abstract Recently, hydrogels have gained significant importance in different applications, such as tissue engineering and drug delivery. They are 3D-structures of hydrophilic polymers held together through physical or chemical cross-linking. Important is their ability to swell in presence of solvents, forming elastic gels able to mantain their original shape. Furthermore, this scaffolds slowly degrade in the physiological environment, leading the growing tissue to replace the former filled site. In this work, hydrogels have been synthetized using branched polyacrilic acid (Carbomer) cross-linked with an aliphatic polyetherdiamine (elastamine). In particular, we focused on the description of their equilibrium conditions in swollen state and the dynamic simulation of the swelling process. These hydrogels exhibited a peculiar swelling behaviour characterized by an overshoot of the volume increase before reaching the equilibrium. Notably, such behavior was found at different pH values. In this manuscript, the swelling behavior was studied by mathematical modelling. Moreover, the ability of these devices to release drugs was also examined through a literature model to understand the different operating transport mechanisms." @default.
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- W3196882753 date "2021-09-01" @default.
- W3196882753 modified "2023-09-23" @default.
- W3196882753 title "Mathematical Modeling of Crosslinked Polyacrylic Based Hydrogels: Physical Properties and Drug Delivery" @default.
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- W3196882753 doi "https://doi.org/10.21203/rs.3.rs-791682/v1" @default.
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