Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196887112> ?p ?o ?g. }
- W3196887112 abstract "ABSTRACT Aedes aegypti has evolved to become an efficient vector for arboviruse s but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its ligand Spaetzle have undergone duplication which may allow neofunctionalization and adaptation. Here we present cryo-EM structures and biophysical characterisation of low affinity Toll5A complexes that display transient but specific interactions with Spaetzle1C, forming asymmetric complexes, with only one ligand clearly resolved. Loop structures of Spaetzle1C and Toll5A intercalate, temporarily bridging the receptor C-termini to promote signalling. By contrast unbound receptors form head-to-head homodimers that keep the juxtamembrane regions far apart in an inactive conformation. Interestingly the transcriptional signature of Spaetzle1C differs from other Spaetzle cytokines and controls genes involved in innate immunity, metabolism and tissue regeneration. Taken together our results explain how upregulation of Spaetzle1C in the midgut and Toll5A in the salivary gland shape the concomitant immune response." @default.
- W3196887112 created "2021-09-13" @default.
- W3196887112 creator A5004146759 @default.
- W3196887112 creator A5011017653 @default.
- W3196887112 creator A5046551506 @default.
- W3196887112 creator A5055170889 @default.
- W3196887112 creator A5057333378 @default.
- W3196887112 creator A5059035701 @default.
- W3196887112 creator A5062184914 @default.
- W3196887112 date "2021-09-06" @default.
- W3196887112 modified "2023-10-02" @default.
- W3196887112 title "Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti" @default.
- W3196887112 cites W1519266993 @default.
- W3196887112 cites W1535872024 @default.
- W3196887112 cites W1607931568 @default.
- W3196887112 cites W1908905777 @default.
- W3196887112 cites W1965064962 @default.
- W3196887112 cites W1971213930 @default.
- W3196887112 cites W1975317507 @default.
- W3196887112 cites W1977038370 @default.
- W3196887112 cites W1984127026 @default.
- W3196887112 cites W1985030583 @default.
- W3196887112 cites W1991894986 @default.
- W3196887112 cites W1992999021 @default.
- W3196887112 cites W1994937883 @default.
- W3196887112 cites W1997889647 @default.
- W3196887112 cites W1998446009 @default.
- W3196887112 cites W1998490570 @default.
- W3196887112 cites W2018731733 @default.
- W3196887112 cites W2030485536 @default.
- W3196887112 cites W2030551855 @default.
- W3196887112 cites W2032056947 @default.
- W3196887112 cites W2038076327 @default.
- W3196887112 cites W2038554653 @default.
- W3196887112 cites W2048067575 @default.
- W3196887112 cites W2049449151 @default.
- W3196887112 cites W2049509883 @default.
- W3196887112 cites W2053551770 @default.
- W3196887112 cites W2056762193 @default.
- W3196887112 cites W2062267695 @default.
- W3196887112 cites W2065276143 @default.
- W3196887112 cites W2074581799 @default.
- W3196887112 cites W2080399344 @default.
- W3196887112 cites W2088079710 @default.
- W3196887112 cites W2090544394 @default.
- W3196887112 cites W2094503313 @default.
- W3196887112 cites W2100935357 @default.
- W3196887112 cites W2107315506 @default.
- W3196887112 cites W2109402288 @default.
- W3196887112 cites W2116368371 @default.
- W3196887112 cites W2117200779 @default.
- W3196887112 cites W2119747146 @default.
- W3196887112 cites W2120772351 @default.
- W3196887112 cites W2124026197 @default.
- W3196887112 cites W2125912444 @default.
- W3196887112 cites W2132629607 @default.
- W3196887112 cites W2139898583 @default.
- W3196887112 cites W2147666668 @default.
- W3196887112 cites W2150736048 @default.
- W3196887112 cites W2162384697 @default.
- W3196887112 cites W2163927033 @default.
- W3196887112 cites W2165664034 @default.
- W3196887112 cites W2171158206 @default.
- W3196887112 cites W2178832778 @default.
- W3196887112 cites W2309536261 @default.
- W3196887112 cites W2380368735 @default.
- W3196887112 cites W2585518426 @default.
- W3196887112 cites W2587625522 @default.
- W3196887112 cites W2605232447 @default.
- W3196887112 cites W2707646777 @default.
- W3196887112 cites W2786390877 @default.
- W3196887112 cites W2791670278 @default.
- W3196887112 cites W2890898877 @default.
- W3196887112 cites W2895963283 @default.
- W3196887112 cites W2939867798 @default.
- W3196887112 cites W2945987049 @default.
- W3196887112 cites W2953798760 @default.
- W3196887112 cites W2977933365 @default.
- W3196887112 cites W2987024024 @default.
- W3196887112 cites W3038183334 @default.
- W3196887112 cites W3063897023 @default.
- W3196887112 cites W3164783274 @default.
- W3196887112 doi "https://doi.org/10.1101/2021.09.06.459066" @default.
- W3196887112 hasPublicationYear "2021" @default.
- W3196887112 type Work @default.
- W3196887112 sameAs 3196887112 @default.
- W3196887112 citedByCount "0" @default.
- W3196887112 crossrefType "posted-content" @default.
- W3196887112 hasAuthorship W3196887112A5004146759 @default.
- W3196887112 hasAuthorship W3196887112A5011017653 @default.
- W3196887112 hasAuthorship W3196887112A5046551506 @default.
- W3196887112 hasAuthorship W3196887112A5055170889 @default.
- W3196887112 hasAuthorship W3196887112A5057333378 @default.
- W3196887112 hasAuthorship W3196887112A5059035701 @default.
- W3196887112 hasAuthorship W3196887112A5062184914 @default.
- W3196887112 hasBestOaLocation W31968871121 @default.
- W3196887112 hasConcept C104317684 @default.
- W3196887112 hasConcept C127561419 @default.
- W3196887112 hasConcept C136449434 @default.
- W3196887112 hasConcept C170493617 @default.