FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196909804> ?p ?o ?g. }

• W3196909804 endingPage "114605" @default.
• W3196909804 startingPage "114605" @default.
• W3196909804 abstract "Hostaflavone A (HA) is a new flavonoid component isolated from the flower of Hosta plantaginea (Lam.) Asch., which is commonly used as a folk herbal to treat inflammatory diseases in China. Nevertheless, the anti-inflammatory effect of HA remains unknown.This work aimed to evaluate the HA with anti-inflammatory activity and mechanism in RAW 264.7 macrophages activated by lipopolysaccharide (LPS).Anti-inflammatory effect of HA was evaluated by measuring of cell viability, nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and IL-6 levels in RAW 264.7 cells. In parallel, the HA action mechanism of nuclear factor kappa B (NF-κB) p65, inhibitor of NF-κB (IκB), inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), c-Jun N-terminal kinases (JNK), extracellular signal-regulated kinase (Erk), p38, and protein kinase B (Akt) were detected by Western blot analysis.HA has no cytotoxicity at concentrations as high as 40 μM. Besides, HA concentration-dependently clearly suppressed the overproduction of NO, PGE2, TNF-α, IL-1β and IL-6 in RAW 264.7 cells induced by LPS. In addition, HA remarkably reduced the upregulation of phosphorylated NF-κB p65, phosphorylated IκB, phosphorylated JNK, phosphorylated Erk and phosphorylated p38, together with iNOS and COX-2 protein expressions in a concentration-dependent manner.HA blocked the LPS activated inflammation via suppressing NF-κB, iNOS, COX-2, mitogen-activated protein kinases (MAPKs) and Akt pathways in RAW 264.7 cells, and might be a new anti-inflammatory agent." @default.
• W3196909804 created "2021-09-13" @default.
• W3196909804 creator A5029240863 @default.
• W3196909804 creator A5047087347 @default.
• W3196909804 creator A5059024183 @default.
• W3196909804 creator A5076809511 @default.
• W3196909804 creator A5080610727 @default.
• W3196909804 creator A5086220146 @default.
• W3196909804 creator A5089061216 @default.
• W3196909804 date "2022-01-01" @default.
• W3196909804 modified "2023-10-15" @default.
• W3196909804 title "Hostaflavone A from Hosta plantaginea (Lam.) Asch. blocked NF-κB/iNOS/COX-2/MAPKs/Akt signaling pathways in LPS-induced RAW 264.7 macrophages" @default.
• W3196909804 cites W2765487753 @default.
• W3196909804 cites W2789103764 @default.
• W3196909804 cites W2804827008 @default.
• W3196909804 cites W2886684148 @default.
• W3196909804 cites W2890185290 @default.
• W3196909804 cites W2899224043 @default.
• W3196909804 cites W2899507146 @default.
• W3196909804 cites W2915204262 @default.
• W3196909804 cites W2982343135 @default.
• W3196909804 cites W2995392821 @default.
• W3196909804 cites W3001433056 @default.
• W3196909804 cites W3038006823 @default.
• W3196909804 cites W3081899524 @default.
• W3196909804 cites W3093627196 @default.
• W3196909804 cites W3108331566 @default.
• W3196909804 cites W3111788417 @default.
• W3196909804 cites W3112483604 @default.
• W3196909804 cites W3131595415 @default.
• W3196909804 cites W3136627203 @default.
• W3196909804 cites W3136924449 @default.
• W3196909804 doi "https://doi.org/10.1016/j.jep.2021.114605" @default.
• W3196909804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34506938" @default.
• W3196909804 hasPublicationYear "2022" @default.
• W3196909804 type Work @default.
• W3196909804 sameAs 3196909804 @default.
• W3196909804 citedByCount "12" @default.
• W3196909804 countsByYear W31969098042022 @default.
• W3196909804 countsByYear W31969098042023 @default.
• W3196909804 crossrefType "journal-article" @default.
• W3196909804 hasAuthorship W3196909804A5029240863 @default.
• W3196909804 hasAuthorship W3196909804A5047087347 @default.
• W3196909804 hasAuthorship W3196909804A5059024183 @default.
• W3196909804 hasAuthorship W3196909804A5076809511 @default.
• W3196909804 hasAuthorship W3196909804A5080610727 @default.
• W3196909804 hasAuthorship W3196909804A5086220146 @default.
• W3196909804 hasAuthorship W3196909804A5089061216 @default.
• W3196909804 hasConcept C11960822 @default.
• W3196909804 hasConcept C153911025 @default.
• W3196909804 hasConcept C178790620 @default.
• W3196909804 hasConcept C17991360 @default.
• W3196909804 hasConcept C184235292 @default.
• W3196909804 hasConcept C185592680 @default.
• W3196909804 hasConcept C203014093 @default.
• W3196909804 hasConcept C2777622882 @default.
• W3196909804 hasConcept C2777730290 @default.
• W3196909804 hasConcept C2779730028 @default.
• W3196909804 hasConcept C51551487 @default.
• W3196909804 hasConcept C519581460 @default.
• W3196909804 hasConcept C55493867 @default.
• W3196909804 hasConcept C57074206 @default.
• W3196909804 hasConcept C62478195 @default.
• W3196909804 hasConcept C75217442 @default.
• W3196909804 hasConcept C86803240 @default.
• W3196909804 hasConcept C95444343 @default.
• W3196909804 hasConcept C98274493 @default.
• W3196909804 hasConceptScore W3196909804C11960822 @default.
• W3196909804 hasConceptScore W3196909804C153911025 @default.
• W3196909804 hasConceptScore W3196909804C178790620 @default.
• W3196909804 hasConceptScore W3196909804C17991360 @default.
• W3196909804 hasConceptScore W3196909804C184235292 @default.
• W3196909804 hasConceptScore W3196909804C185592680 @default.
• W3196909804 hasConceptScore W3196909804C203014093 @default.
• W3196909804 hasConceptScore W3196909804C2777622882 @default.
• W3196909804 hasConceptScore W3196909804C2777730290 @default.
• W3196909804 hasConceptScore W3196909804C2779730028 @default.
• W3196909804 hasConceptScore W3196909804C51551487 @default.
• W3196909804 hasConceptScore W3196909804C519581460 @default.
• W3196909804 hasConceptScore W3196909804C55493867 @default.
• W3196909804 hasConceptScore W3196909804C57074206 @default.
• W3196909804 hasConceptScore W3196909804C62478195 @default.
• W3196909804 hasConceptScore W3196909804C75217442 @default.
• W3196909804 hasConceptScore W3196909804C86803240 @default.
• W3196909804 hasConceptScore W3196909804C95444343 @default.
• W3196909804 hasConceptScore W3196909804C98274493 @default.
• W3196909804 hasFunder F4320321001 @default.
• W3196909804 hasFunder F4320322665 @default.
• W3196909804 hasLocation W31969098041 @default.
• W3196909804 hasLocation W31969098042 @default.
• W3196909804 hasOpenAccess W3196909804 @default.
• W3196909804 hasPrimaryLocation W31969098041 @default.
• W3196909804 hasRelatedWork W2028293395 @default.
• W3196909804 hasRelatedWork W2028577310 @default.
• W3196909804 hasRelatedWork W2056415482 @default.
• W3196909804 hasRelatedWork W2067160292 @default.
• W3196909804 hasRelatedWork W2376631516 @default.
• W3196909804 hasRelatedWork W2419118008 @default.

• next