FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196936640> ?p ?o ?g. }

• W3196936640 abstract "Abstract Homeostasis is one of the fundamental concepts in physiology. Despite remarkable progress in our molecular understanding of amino acid transport, metabolism and signaling, it remains unclear by what mechanisms cytosolic amino acid concentrations are maintained. We propose that amino acid transporters are the primary determinants of intracellular amino acid levels. We show that a cell’s endowment with amino acid transporters can be deconvoluted experimentally and used this data to computationally simulate amino acid translocation across the plasma membrane. Transport simulation generates cytosolic amino acid concentrations that are close to those observed in vitro. Perturbations of the system are replicated in silico and can be applied to systems where only transcriptomic data are available. This work explains amino acid homeostasis at the systems-level, through a combination of secondary active transporters, functionally acting as loaders, harmonizers and controller transporters to generate a stable equilibrium of all amino acid concentrations." @default.
• W3196936640 created "2021-09-13" @default.
• W3196936640 creator A5003058857 @default.
• W3196936640 creator A5006813716 @default.
• W3196936640 creator A5012651609 @default.
• W3196936640 creator A5024918953 @default.
• W3196936640 creator A5048653710 @default.
• W3196936640 creator A5052998785 @default.
• W3196936640 creator A5061657678 @default.
• W3196936640 creator A5074021013 @default.
• W3196936640 date "2021-09-06" @default.
• W3196936640 modified "2023-10-02" @default.
• W3196936640 title "Quantitative modelling of amino acid transport and homeostasis in mammalian cells" @default.
• W3196936640 cites W1571311092 @default.
• W3196936640 cites W1956844386 @default.
• W3196936640 cites W1963940212 @default.
• W3196936640 cites W1965138514 @default.
• W3196936640 cites W1967527526 @default.
• W3196936640 cites W1971597300 @default.
• W3196936640 cites W1972806358 @default.
• W3196936640 cites W1976754780 @default.
• W3196936640 cites W1977923848 @default.
• W3196936640 cites W1981206208 @default.
• W3196936640 cites W1981504804 @default.
• W3196936640 cites W1994257789 @default.
• W3196936640 cites W2004975140 @default.
• W3196936640 cites W2009811621 @default.
• W3196936640 cites W2013281367 @default.
• W3196936640 cites W2013821006 @default.
• W3196936640 cites W2020196369 @default.
• W3196936640 cites W2022628608 @default.
• W3196936640 cites W2033186137 @default.
• W3196936640 cites W2041518368 @default.
• W3196936640 cites W2055255976 @default.
• W3196936640 cites W2055586221 @default.
• W3196936640 cites W2060224220 @default.
• W3196936640 cites W2083720677 @default.
• W3196936640 cites W2084685608 @default.
• W3196936640 cites W2086528604 @default.
• W3196936640 cites W2093154482 @default.
• W3196936640 cites W2094791437 @default.
• W3196936640 cites W2099540110 @default.
• W3196936640 cites W2108195113 @default.
• W3196936640 cites W2110337284 @default.
• W3196936640 cites W2119255682 @default.
• W3196936640 cites W2122930447 @default.
• W3196936640 cites W2132117833 @default.
• W3196936640 cites W2135170450 @default.
• W3196936640 cites W2137749199 @default.
• W3196936640 cites W2141948588 @default.
• W3196936640 cites W2144325627 @default.
• W3196936640 cites W2145642904 @default.
• W3196936640 cites W2155760865 @default.
• W3196936640 cites W2205432407 @default.
• W3196936640 cites W2206269655 @default.
• W3196936640 cites W2257572427 @default.
• W3196936640 cites W2293646973 @default.
• W3196936640 cites W2343975196 @default.
• W3196936640 cites W2521819798 @default.
• W3196936640 cites W2592356929 @default.
• W3196936640 cites W2617696743 @default.
• W3196936640 cites W2739510344 @default.
• W3196936640 cites W2792102657 @default.
• W3196936640 cites W2806477979 @default.
• W3196936640 cites W2911182703 @default.
• W3196936640 cites W2940303196 @default.
• W3196936640 cites W2957934505 @default.
• W3196936640 cites W2970715912 @default.
• W3196936640 cites W2975860835 @default.
• W3196936640 cites W3018608736 @default.
• W3196936640 cites W3080559268 @default.
• W3196936640 cites W3081868833 @default.
• W3196936640 cites W3135675512 @default.
• W3196936640 cites W3154325663 @default.
• W3196936640 cites W345799354 @default.
• W3196936640 doi "https://doi.org/10.1038/s41467-021-25563-x" @default.
• W3196936640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8421413" @default.
• W3196936640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34489418" @default.
• W3196936640 hasPublicationYear "2021" @default.
• W3196936640 type Work @default.
• W3196936640 sameAs 3196936640 @default.
• W3196936640 citedByCount "29" @default.
• W3196936640 countsByYear W31969366402021 @default.
• W3196936640 countsByYear W31969366402022 @default.
• W3196936640 countsByYear W31969366402023 @default.
• W3196936640 crossrefType "journal-article" @default.
• W3196936640 hasAuthorship W3196936640A5003058857 @default.
• W3196936640 hasAuthorship W3196936640A5006813716 @default.
• W3196936640 hasAuthorship W3196936640A5012651609 @default.
• W3196936640 hasAuthorship W3196936640A5024918953 @default.
• W3196936640 hasAuthorship W3196936640A5048653710 @default.
• W3196936640 hasAuthorship W3196936640A5052998785 @default.
• W3196936640 hasAuthorship W3196936640A5061657678 @default.
• W3196936640 hasAuthorship W3196936640A5074021013 @default.
• W3196936640 hasBestOaLocation W31969366401 @default.
• W3196936640 hasConcept C104317684 @default.
• W3196936640 hasConcept C149011108 @default.
• W3196936640 hasConcept C181199279 @default.
• W3196936640 hasConcept C185592680 @default.
• W3196936640 hasConcept C2775905019 @default.

• next