Matches in SemOpenAlex for { <https://semopenalex.org/work/W3196985151> ?p ?o ?g. }
- W3196985151 endingPage "5150.e12" @default.
- W3196985151 startingPage "5138" @default.
- W3196985151 abstract "Many transient receptor potential (TRP) channels respond to diverse stimuli and conditionally conduct small and large cations. Such functional plasticity is presumably enabled by a uniquely dynamic ion selectivity filter that is regulated by physiological agents. What is currently missing is a photo series of intermediate structural states that directly address this hypothesis and reveal specific mechanisms behind such dynamic channel regulation. Here, we exploit cryoelectron microscopy (cryo-EM) to visualize conformational transitions of the capsaicin receptor, TRPV1, as a model to understand how dynamic transitions of the selectivity filter in response to algogenic agents, including protons, vanilloid agonists, and peptide toxins, permit permeation by small and large organic cations. These structures also reveal mechanisms governing ligand binding substates, as well as allosteric coupling between key sites that are proximal to the selectivity filter and cytoplasmic gate. These insights suggest a general framework for understanding how TRP channels function as polymodal signal integrators." @default.
- W3196985151 created "2021-09-13" @default.
- W3196985151 creator A5007893484 @default.
- W3196985151 creator A5014886042 @default.
- W3196985151 creator A5016221669 @default.
- W3196985151 date "2021-09-01" @default.
- W3196985151 modified "2023-10-14" @default.
- W3196985151 title "Structural snapshots of TRPV1 reveal mechanism of polymodal functionality" @default.
- W3196985151 cites W1511198581 @default.
- W3196985151 cites W1524500351 @default.
- W3196985151 cites W1548902459 @default.
- W3196985151 cites W1790023182 @default.
- W3196985151 cites W1959838017 @default.
- W3196985151 cites W1973796039 @default.
- W3196985151 cites W1974641725 @default.
- W3196985151 cites W1984533345 @default.
- W3196985151 cites W1988174555 @default.
- W3196985151 cites W1995808589 @default.
- W3196985151 cites W1997454260 @default.
- W3196985151 cites W2005505879 @default.
- W3196985151 cites W2006775310 @default.
- W3196985151 cites W2016194590 @default.
- W3196985151 cites W2016821576 @default.
- W3196985151 cites W2029582401 @default.
- W3196985151 cites W2033457590 @default.
- W3196985151 cites W2039263844 @default.
- W3196985151 cites W2043901383 @default.
- W3196985151 cites W2047169541 @default.
- W3196985151 cites W2050781058 @default.
- W3196985151 cites W2083189824 @default.
- W3196985151 cites W2088764206 @default.
- W3196985151 cites W2107705149 @default.
- W3196985151 cites W2108906526 @default.
- W3196985151 cites W2109613748 @default.
- W3196985151 cites W2124026197 @default.
- W3196985151 cites W2124653618 @default.
- W3196985151 cites W2128865950 @default.
- W3196985151 cites W2132629607 @default.
- W3196985151 cites W2134742719 @default.
- W3196985151 cites W2136716118 @default.
- W3196985151 cites W2142161929 @default.
- W3196985151 cites W2152562710 @default.
- W3196985151 cites W2164659462 @default.
- W3196985151 cites W2168210103 @default.
- W3196985151 cites W2168240189 @default.
- W3196985151 cites W2180229411 @default.
- W3196985151 cites W2301186499 @default.
- W3196985151 cites W2323300135 @default.
- W3196985151 cites W2404622021 @default.
- W3196985151 cites W2419518257 @default.
- W3196985151 cites W2553110874 @default.
- W3196985151 cites W2587625522 @default.
- W3196985151 cites W2593511418 @default.
- W3196985151 cites W2734356283 @default.
- W3196985151 cites W2774013165 @default.
- W3196985151 cites W2777934057 @default.
- W3196985151 cites W2786390877 @default.
- W3196985151 cites W2791354025 @default.
- W3196985151 cites W2799315094 @default.
- W3196985151 cites W2801376357 @default.
- W3196985151 cites W2885180300 @default.
- W3196985151 cites W2887263514 @default.
- W3196985151 cites W2894951265 @default.
- W3196985151 cites W2899714098 @default.
- W3196985151 cites W2900599829 @default.
- W3196985151 cites W2950967305 @default.
- W3196985151 cites W2963870305 @default.
- W3196985151 cites W2969843240 @default.
- W3196985151 cites W2978944334 @default.
- W3196985151 cites W2981514797 @default.
- W3196985151 cites W2987639883 @default.
- W3196985151 cites W3003974826 @default.
- W3196985151 cites W3013056151 @default.
- W3196985151 cites W3035806878 @default.
- W3196985151 cites W3041083155 @default.
- W3196985151 cites W3128479088 @default.
- W3196985151 cites W3156271189 @default.
- W3196985151 cites W4247052853 @default.
- W3196985151 cites W4252314477 @default.
- W3196985151 cites W977835016 @default.
- W3196985151 doi "https://doi.org/10.1016/j.cell.2021.08.012" @default.
- W3196985151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8488022" @default.
- W3196985151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34496225" @default.
- W3196985151 hasPublicationYear "2021" @default.
- W3196985151 type Work @default.
- W3196985151 sameAs 3196985151 @default.
- W3196985151 citedByCount "81" @default.
- W3196985151 countsByYear W31969851512021 @default.
- W3196985151 countsByYear W31969851512022 @default.
- W3196985151 countsByYear W31969851512023 @default.
- W3196985151 crossrefType "journal-article" @default.
- W3196985151 hasAuthorship W3196985151A5007893484 @default.
- W3196985151 hasAuthorship W3196985151A5014886042 @default.
- W3196985151 hasAuthorship W3196985151A5016221669 @default.
- W3196985151 hasBestOaLocation W31969851511 @default.
- W3196985151 hasConcept C12554922 @default.
- W3196985151 hasConcept C155164980 @default.
- W3196985151 hasConcept C160145004 @default.