FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197021703> ?p ?o ?g. }

• W3197021703 endingPage "102197" @default.
• W3197021703 startingPage "102197" @default.
• W3197021703 abstract "Alzheimer's disease (AD) is a serious, progressive neurodegenerative disease that involves irreversible neuronal death. Tetrahydroxy stilbene glycoside (TSG) is an active compound extracted from P. multiflorum, a traditional Chinese herbal medicine, but its role in neuroprotection is unclear. Herein, we aimed to validate the effects of TSG on APP/PS1 model mice and the underlying mechanism. RNA-seq was performed to identify differentially expressed genes in APP/PS1 mouse, with PCR and immunohistochemistry used for validation. Experiments were performed after bioinformatic analysis for verification. Neuronal damage was observed by H&E staining. Key proteins involved in the pathway such as CX3CR1, Iba1 and TGF-β were examined by immunohistochemical analysis. The KEGG analysis suggested that these genes might act by multiple pathways to build the pharmacological network of TSG in AD progression. These data provide the credible evidence that TSG improved neuronal damage and regulated neuroprotective mechanisms. Together, our work has detailed the whole and major genes in APP/PS1 model mouse regulated by TSG, and highlighted the anti-inflammatory function of TSG in mediating CX3CR1 and TGF-β as the TGF-β/fractalkine/CX3XR1 signaling pathway, especially in microglia. Moreover, TSG has potential value in synaptic transmission and neurotrophic action on neurodegenerative diseases. In summary, TSG is a promising candidate for preventing and treating the progression of AD." @default.
• W3197021703 created "2021-09-13" @default.
• W3197021703 creator A5002649440 @default.
• W3197021703 creator A5003547177 @default.
• W3197021703 creator A5004231851 @default.
• W3197021703 creator A5046387752 @default.
• W3197021703 creator A5069255635 @default.
• W3197021703 creator A5071811404 @default.
• W3197021703 creator A5075444205 @default.
• W3197021703 creator A5077749592 @default.
• W3197021703 creator A5085626784 @default.
• W3197021703 creator A5087364900 @default.
• W3197021703 date "2021-12-01" @default.
• W3197021703 modified "2023-09-27" @default.
• W3197021703 title "Tetrahydroxy stilbene glycoside regulates TGF-β/fractalkine/CX3CR1 based on network pharmacology in APP/PS1 mouse model" @default.
• W3197021703 cites W1616122655 @default.
• W3197021703 cites W1952975321 @default.
• W3197021703 cites W1974640999 @default.
• W3197021703 cites W1980132630 @default.
• W3197021703 cites W1981509058 @default.
• W3197021703 cites W1984075660 @default.
• W3197021703 cites W1990703634 @default.
• W3197021703 cites W2002292205 @default.
• W3197021703 cites W2004349171 @default.
• W3197021703 cites W2018848590 @default.
• W3197021703 cites W2025732663 @default.
• W3197021703 cites W2028896816 @default.
• W3197021703 cites W2034764339 @default.
• W3197021703 cites W2060155793 @default.
• W3197021703 cites W2081164888 @default.
• W3197021703 cites W2086776463 @default.
• W3197021703 cites W2103563178 @default.
• W3197021703 cites W2113107925 @default.
• W3197021703 cites W2131088968 @default.
• W3197021703 cites W2135111297 @default.
• W3197021703 cites W2149517369 @default.
• W3197021703 cites W2153747061 @default.
• W3197021703 cites W2154431984 @default.
• W3197021703 cites W2160031422 @default.
• W3197021703 cites W2162934206 @default.
• W3197021703 cites W2255215236 @default.
• W3197021703 cites W2273901578 @default.
• W3197021703 cites W2347012456 @default.
• W3197021703 cites W2411818373 @default.
• W3197021703 cites W2484335322 @default.
• W3197021703 cites W2516144497 @default.
• W3197021703 cites W2563545201 @default.
• W3197021703 cites W2606464255 @default.
• W3197021703 cites W2617852164 @default.
• W3197021703 cites W2768336076 @default.
• W3197021703 cites W2891497275 @default.
• W3197021703 cites W2913000824 @default.
• W3197021703 cites W2919480138 @default.
• W3197021703 cites W3042305168 @default.
• W3197021703 cites W3090445757 @default.
• W3197021703 cites W3107829607 @default.
• W3197021703 doi "https://doi.org/10.1016/j.npep.2021.102197" @default.
• W3197021703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34509715" @default.
• W3197021703 hasPublicationYear "2021" @default.
• W3197021703 type Work @default.
• W3197021703 sameAs 3197021703 @default.
• W3197021703 citedByCount "1" @default.
• W3197021703 countsByYear W31970217032023 @default.
• W3197021703 crossrefType "journal-article" @default.
• W3197021703 hasAuthorship W3197021703A5002649440 @default.
• W3197021703 hasAuthorship W3197021703A5003547177 @default.
• W3197021703 hasAuthorship W3197021703A5004231851 @default.
• W3197021703 hasAuthorship W3197021703A5046387752 @default.
• W3197021703 hasAuthorship W3197021703A5069255635 @default.
• W3197021703 hasAuthorship W3197021703A5071811404 @default.
• W3197021703 hasAuthorship W3197021703A5075444205 @default.
• W3197021703 hasAuthorship W3197021703A5077749592 @default.
• W3197021703 hasAuthorship W3197021703A5085626784 @default.
• W3197021703 hasAuthorship W3197021703A5087364900 @default.
• W3197021703 hasConcept C104317684 @default.
• W3197021703 hasConcept C118131993 @default.
• W3197021703 hasConcept C150194340 @default.
• W3197021703 hasConcept C152724338 @default.
• W3197021703 hasConcept C160539049 @default.
• W3197021703 hasConcept C162317418 @default.
• W3197021703 hasConcept C169760540 @default.
• W3197021703 hasConcept C170493617 @default.
• W3197021703 hasConcept C203014093 @default.
• W3197021703 hasConcept C25498285 @default.
• W3197021703 hasConcept C2776914184 @default.
• W3197021703 hasConcept C2779830541 @default.
• W3197021703 hasConcept C55493867 @default.
• W3197021703 hasConcept C86803240 @default.
• W3197021703 hasConcept C92020748 @default.
• W3197021703 hasConcept C95444343 @default.
• W3197021703 hasConcept C98274493 @default.
• W3197021703 hasConceptScore W3197021703C104317684 @default.
• W3197021703 hasConceptScore W3197021703C118131993 @default.
• W3197021703 hasConceptScore W3197021703C150194340 @default.
• W3197021703 hasConceptScore W3197021703C152724338 @default.
• W3197021703 hasConceptScore W3197021703C160539049 @default.
• W3197021703 hasConceptScore W3197021703C162317418 @default.
• W3197021703 hasConceptScore W3197021703C169760540 @default.

• next