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- W3197074008 abstract "OBJECTIVE High risk human papillomavirus(HPV)infection is associated with the development of multiple head and neck squamous cell carcinomas(HNSCC).Oropharyngeal squamous cell carcinoma(OPSCC)is a common type of HNSCC.In this study,HPV infection and the expression of p53,p21 and Cdc2 protein in OPSCC tissues was detected,and the prognostic factors and clinical detection value of OPSCC were discussed.METHODS Totally 49 cases with complete clinical data of OPSCC wax block were collected from of Tangshan Xiehe Hospital head and neck pathology research base from January 1,2012 to December 31,2017.The expression of E6 and E7 mRNA of HPV 16 and HPV 18 in tumor tissue was detected by RNAscope in situ hybridization,and the expression of p53,p21 and Cdc2 protein was observed by SP immunohistochemical method.All cases were followed up for survival.Using SPSS24.0 statistical software,median survival time was analyzed with Kaplan-Meier method.The Log-rank test was used for single factor analysis and Cox Regression model was used to analyze multiple factors of prognosis.RESULTS HPV-DNA detection was positive in 28.6%(14/49)and negative in 71.4%(35/49).All cases were tested for HPV16 E6 and E7 mRNA,and the positive rate was 40.8%(20/49),among which 11 cases were HPV 16 DNA positive.HPV 18-mRNA positive patients were4.08%(2/49).HPV16/18 mRNA negative patients accounted for 55.1%(27/49).The prevalence of HPV was 68.8%(11/16)in the non-smoking Group,higher than in smoking group 33.3%(10/33),χ2=5.463,P 0.05.The expression rate of p53 was 63.3%(31/49),p21 was 65.3%(32/49),and cdc2 was 67.3%(33/49).The expression of p53,p21 and Cdc2 was not related to gender,age,smoking,drinking,tumor differentiation and clinical stage,P>0.05.HPV infection was not associated to the expression of p53,p21 and Cdc2,P>0.05.Cox multifactor regression analysis showed that HPV infection(HR=0.275,95%CI:0.146-0.517),tumor differentiation(HR=1.751,95%CI:1.231-2.492),stage(HR=3.268,95%CI:1.758-6.074),and expression of Cdc2 protein(HR=1.804,95%CI:0.990-3.286)were related to the survival time of patients,P<0.05.CONCLUSIONS Most of the HPV positive OPSSC patients are non-smokers.The patients with HPV negative,low differentiation,late stage and positive expression of Cdc2 suggest poor prognosis and need to be followed up." @default.
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- W3197074008 date "2020-01-01" @default.
- W3197074008 modified "2023-09-27" @default.
- W3197074008 title "Correlation analysis of 49 cases of oropharyngeal squamous cell carcinoma and high-risk HPV infection" @default.
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