Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197096670> ?p ?o ?g. }
- W3197096670 abstract "Abstract Background The use of genome-wide sequencing in pediatric medicine and research is growing exponentially. While this has many potential benefits, the normative and empirical literature has highlighted various ethical issues. There have not been, however, any systematic reviews of these issues. The aim of this systematic review is to determine systematically the spectrum of ethical issues that is raised for stakeholders in in pediatric genome-wide sequencing. Methods A systematic review in PubMed and Google Books (publications in English or German between 2004 and 2021) was conducted. Further references were identified via reference screening. Data were analyzed and synthesized using qualitative content analysis. Ethical issues were defined as arising when a relevant normative principle is not adequately considered or when two principles come into conflict. Results Our literature search retrieved 3175 publications of which 143 were included in the analysis. Together these mentioned 106 ethical issues in pediatric genome-wide sequencing, categorized into five themes along the pediatric genome-wide sequencing lifecycle. Most ethical issues identified in relation to genome-wide sequencing typically reflect ethical issues that arise in general genetic testing, but they are often amplified by the increased quantity of data obtained, and associated uncertainties. The most frequently discussed ethical aspects concern the issue of unsolicited findings. Conclusion Concentration of the debate on unsolicited findings risks overlooking other ethical challenges. An overarching difficulty presents the terminological confusion: both with regard to both the test procedure/ the scope of analysis, as well as with the topic of unsolicited findings. It is important that the genetics and ethics communities together with other medical professions involved work jointly on specific case related guidelines to grant the maximum benefit for the care of the children, while preventing patient harm and disproportionate overload of clinicians and the healthcare system by the wealth of available options and economic incentives to increase testing." @default.
- W3197096670 created "2021-09-13" @default.
- W3197096670 creator A5009805392 @default.
- W3197096670 creator A5014918487 @default.
- W3197096670 creator A5020702389 @default.
- W3197096670 creator A5020942789 @default.
- W3197096670 creator A5070169847 @default.
- W3197096670 creator A5073214847 @default.
- W3197096670 creator A5080640272 @default.
- W3197096670 date "2021-09-06" @default.
- W3197096670 modified "2023-10-16" @default.
- W3197096670 title "The full spectrum of ethical issues in pediatric genome-wide sequencing: a systematic qualitative review" @default.
- W3197096670 cites W1437612076 @default.
- W3197096670 cites W1548237291 @default.
- W3197096670 cites W1594146628 @default.
- W3197096670 cites W1719577064 @default.
- W3197096670 cites W1802661291 @default.
- W3197096670 cites W1844528855 @default.
- W3197096670 cites W1925825565 @default.
- W3197096670 cites W1961088832 @default.
- W3197096670 cites W1965659199 @default.
- W3197096670 cites W1969844462 @default.
- W3197096670 cites W1982488949 @default.
- W3197096670 cites W1999451199 @default.
- W3197096670 cites W2002234150 @default.
- W3197096670 cites W2021829252 @default.
- W3197096670 cites W2044018960 @default.
- W3197096670 cites W2048039005 @default.
- W3197096670 cites W2053039372 @default.
- W3197096670 cites W2073536755 @default.
- W3197096670 cites W2084242289 @default.
- W3197096670 cites W2084717763 @default.
- W3197096670 cites W2084959321 @default.
- W3197096670 cites W2087547100 @default.
- W3197096670 cites W2087849358 @default.
- W3197096670 cites W2099931467 @default.
- W3197096670 cites W2101497968 @default.
- W3197096670 cites W2120494409 @default.
- W3197096670 cites W2123843156 @default.
- W3197096670 cites W2129797254 @default.
- W3197096670 cites W2143626981 @default.
- W3197096670 cites W2176972283 @default.
- W3197096670 cites W2186270799 @default.
- W3197096670 cites W2194988984 @default.
- W3197096670 cites W2226624445 @default.
- W3197096670 cites W2286007596 @default.
- W3197096670 cites W2291348792 @default.
- W3197096670 cites W2326059418 @default.
- W3197096670 cites W2338490151 @default.
- W3197096670 cites W2339394132 @default.
- W3197096670 cites W2339769955 @default.
- W3197096670 cites W2344999666 @default.
- W3197096670 cites W2346362370 @default.
- W3197096670 cites W2362445007 @default.
- W3197096670 cites W2394882017 @default.
- W3197096670 cites W2413014166 @default.
- W3197096670 cites W2460562489 @default.
- W3197096670 cites W2465862272 @default.
- W3197096670 cites W2516516428 @default.
- W3197096670 cites W2517276995 @default.
- W3197096670 cites W2529524331 @default.
- W3197096670 cites W2552650277 @default.
- W3197096670 cites W2581761974 @default.
- W3197096670 cites W2582535998 @default.
- W3197096670 cites W2591417052 @default.
- W3197096670 cites W2605447746 @default.
- W3197096670 cites W2763655193 @default.
- W3197096670 cites W2770011202 @default.
- W3197096670 cites W2782895599 @default.
- W3197096670 cites W2792060597 @default.
- W3197096670 cites W2792215406 @default.
- W3197096670 cites W2806678685 @default.
- W3197096670 cites W2807847174 @default.
- W3197096670 cites W2808235019 @default.
- W3197096670 cites W2811271190 @default.
- W3197096670 cites W2889213402 @default.
- W3197096670 cites W2890809937 @default.
- W3197096670 cites W2895349927 @default.
- W3197096670 cites W2903311129 @default.
- W3197096670 cites W2907335912 @default.
- W3197096670 cites W2907453142 @default.
- W3197096670 cites W2907965986 @default.
- W3197096670 cites W2908039020 @default.
- W3197096670 cites W2910848546 @default.
- W3197096670 cites W2911835519 @default.
- W3197096670 cites W2913167410 @default.
- W3197096670 cites W2934916446 @default.
- W3197096670 cites W2975298736 @default.
- W3197096670 cites W3021531002 @default.
- W3197096670 cites W3022961025 @default.
- W3197096670 cites W3023382839 @default.
- W3197096670 cites W3037802599 @default.
- W3197096670 cites W3082762427 @default.
- W3197096670 cites W3095319765 @default.
- W3197096670 cites W3148962211 @default.
- W3197096670 cites W4210963813 @default.
- W3197096670 cites W4245061101 @default.
- W3197096670 cites W4249815986 @default.
- W3197096670 cites W811091590 @default.
- W3197096670 cites W977925457 @default.