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- W3197102703 abstract "CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface marker of self that binds SIRPα and inhibits macrophage phagocytosis, and cancer immuno-therapy approaches in clinical trials are focused on blocking CD47/SIRPα interaction. We present the crystal structure of full length CD47 bound to the function-blocking antibody B6H12. CD47 ECD is tethered to the TM domain via a six-residue peptide linker (114RVVSWF119) that forms an extended loop (SWF loop), with the fundamental role of inserting the side chains of W118 and F119 into the core of CD47 extracellular loop region (ECLR). Using hydrogen-deuterium exchange and molecular dynamics simulations we show that CD47's ECLR architecture, comprised of two extracellular loops and the SWF loop, creates a molecular environment stabilizing the ECD for presentation on the cell surface. These findings provide insights into CD47 immune recognition, signaling and therapeutic intervention." @default.
- W3197102703 created "2021-09-13" @default.
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- W3197102703 date "2021-09-01" @default.
- W3197102703 modified "2023-10-16" @default.
- W3197102703 title "Structure of the human marker of self 5-transmembrane receptor CD47" @default.
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- W3197102703 cites W1994342014 @default.
- W3197102703 cites W2001302355 @default.
- W3197102703 cites W2001570963 @default.
- W3197102703 cites W2002220495 @default.
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- W3197102703 cites W2009148545 @default.
- W3197102703 cites W2011655736 @default.
- W3197102703 cites W2017555329 @default.
- W3197102703 cites W2028890259 @default.
- W3197102703 cites W2031391894 @default.
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- W3197102703 cites W2153228625 @default.
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- W3197102703 cites W2157737388 @default.
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- W3197102703 doi "https://doi.org/10.1038/s41467-021-25475-w" @default.
- W3197102703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8410850" @default.
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- W3197102703 hasPublicationYear "2021" @default.
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