FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197103660> ?p ?o ?g. }

• W3197103660 endingPage "112746" @default.
• W3197103660 startingPage "112746" @default.
• W3197103660 abstract "Betulinic acid (BA), a pentacyclic triterpenoid, has been associated with several biological effects, such as antioxidant, anti-inflammatory and antiviral activities. Previous studies have demonstrated that BA has the ability to alleviate intestinal mucosal damage, however, the potential mechanism associated with the effect has not been reported. This study aimed to investigate the possible protective mechanism of BA against cyclophosphamide (CYP)-induced intestinal mucosal damage. Here, we found that BA pretreatment prevented intestinal mucosal barrier dysfuction from CYP-challenged mice by repairing the intestinal physical, chemical, and immune barriers. Moreover, BA treatment suppressed the CYP-induced oxidative stress by activating the nuclear factor erythroid 2 [NF-E2]-related factor (Nrf2) pathway blocked reactive oxygen species (ROS) accumulation. In addition, BA inhibited CYP-triggered intestinal inflammation through down-regulating the nuclear transcription factor kappa B (NF-κB)/mitogen-activating protein kinase (MAPK) pathways. Furthermore, BA pretreatment reduced intestinal apoptosis by blocking ROS-activated mitochondrial apoptotic pathway. Overall, the current study demonstrated the protective effect of BA against CYP-caused intestinal mucosal damage by regulating the Nrf2 and NF-κB/MAPK signalling pathways, which may provide new therapeutic targets to attenuate intestinal impairment and maintain intestinal health. BA provides protection against CYP-induced intestinal mucosal damage in mice, which may be attributed to its anti-inflammation and antioxidant activities as well as its ability to inhibit apoptosis. In addition, the effects of BA may be mediated by the inhibition of the NF-κB/MAPK signalling pathways and the activation of the Nrf2 signalling pathway. • BA alleviated CYP-induced intestinal barrier dysfunction. • BA inhibited intestinal inflammation by down-regulating NF-κB/MAPK pathway. • BA reduced intestinal oxidative stress by activating Nrf2 blocked ROS accumulation. • BA reduced intestinal apoptosis by inhibiting ROS-activated mitochondrial apoptotic pathway." @default.
• W3197103660 created "2021-09-13" @default.
• W3197103660 creator A5004228802 @default.
• W3197103660 creator A5009570277 @default.
• W3197103660 creator A5016194081 @default.
• W3197103660 creator A5018904393 @default.
• W3197103660 creator A5023280203 @default.
• W3197103660 creator A5038493861 @default.
• W3197103660 creator A5049998731 @default.
• W3197103660 creator A5057213426 @default.
• W3197103660 creator A5070564367 @default.
• W3197103660 creator A5074327970 @default.
• W3197103660 creator A5076026075 @default.
• W3197103660 creator A5086775048 @default.
• W3197103660 creator A5088634717 @default.
• W3197103660 date "2021-12-01" @default.
• W3197103660 modified "2023-10-13" @default.
• W3197103660 title "Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 signalling pathway" @default.
• W3197103660 cites W1040014357 @default.
• W3197103660 cites W1567791639 @default.
• W3197103660 cites W1972163315 @default.
• W3197103660 cites W1980799612 @default.
• W3197103660 cites W1981105280 @default.
• W3197103660 cites W1995192043 @default.
• W3197103660 cites W2011539123 @default.
• W3197103660 cites W2014023055 @default.
• W3197103660 cites W2038918212 @default.
• W3197103660 cites W2048497662 @default.
• W3197103660 cites W2051092344 @default.
• W3197103660 cites W2051610866 @default.
• W3197103660 cites W2067668617 @default.
• W3197103660 cites W2087691479 @default.
• W3197103660 cites W2087973947 @default.
• W3197103660 cites W2117800935 @default.
• W3197103660 cites W2120659487 @default.
• W3197103660 cites W2124211577 @default.
• W3197103660 cites W2138419579 @default.
• W3197103660 cites W2161220011 @default.
• W3197103660 cites W2314654494 @default.
• W3197103660 cites W2320904587 @default.
• W3197103660 cites W2331201236 @default.
• W3197103660 cites W2604234420 @default.
• W3197103660 cites W2605388267 @default.
• W3197103660 cites W2734631196 @default.
• W3197103660 cites W2770039758 @default.
• W3197103660 cites W2792651356 @default.
• W3197103660 cites W2794233257 @default.
• W3197103660 cites W2805758681 @default.
• W3197103660 cites W2805982252 @default.
• W3197103660 cites W2887618417 @default.
• W3197103660 cites W2902628935 @default.
• W3197103660 cites W2905312073 @default.
• W3197103660 cites W2908031418 @default.
• W3197103660 cites W2944761905 @default.
• W3197103660 cites W2951509935 @default.
• W3197103660 cites W2965176499 @default.
• W3197103660 cites W2967637185 @default.
• W3197103660 cites W2969512896 @default.
• W3197103660 cites W2973222161 @default.
• W3197103660 cites W2979744254 @default.
• W3197103660 cites W2983872261 @default.
• W3197103660 cites W3024111287 @default.
• W3197103660 cites W3028702886 @default.
• W3197103660 cites W3050443461 @default.
• W3197103660 cites W3080528769 @default.
• W3197103660 cites W3113277777 @default.
• W3197103660 cites W3122463983 @default.
• W3197103660 cites W3133250803 @default.
• W3197103660 cites W3134145726 @default.
• W3197103660 cites W3168409627 @default.
• W3197103660 cites W3171747484 @default.
• W3197103660 doi "https://doi.org/10.1016/j.ecoenv.2021.112746" @default.
• W3197103660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34482064" @default.
• W3197103660 hasPublicationYear "2021" @default.
• W3197103660 type Work @default.
• W3197103660 sameAs 3197103660 @default.
• W3197103660 citedByCount "14" @default.
• W3197103660 countsByYear W31971036602022 @default.
• W3197103660 countsByYear W31971036602023 @default.
• W3197103660 crossrefType "journal-article" @default.
• W3197103660 hasAuthorship W3197103660A5004228802 @default.
• W3197103660 hasAuthorship W3197103660A5009570277 @default.
• W3197103660 hasAuthorship W3197103660A5016194081 @default.
• W3197103660 hasAuthorship W3197103660A5018904393 @default.
• W3197103660 hasAuthorship W3197103660A5023280203 @default.
• W3197103660 hasAuthorship W3197103660A5038493861 @default.
• W3197103660 hasAuthorship W3197103660A5049998731 @default.
• W3197103660 hasAuthorship W3197103660A5057213426 @default.
• W3197103660 hasAuthorship W3197103660A5070564367 @default.
• W3197103660 hasAuthorship W3197103660A5074327970 @default.
• W3197103660 hasAuthorship W3197103660A5076026075 @default.
• W3197103660 hasAuthorship W3197103660A5086775048 @default.
• W3197103660 hasAuthorship W3197103660A5088634717 @default.
• W3197103660 hasBestOaLocation W31971036601 @default.
• W3197103660 hasConcept C126322002 @default.
• W3197103660 hasConcept C185592680 @default.
• W3197103660 hasConcept C2777730290 @default.
• W3197103660 hasConcept C2777829905 @default.

• next