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• W3197111036 abstract "• The bovine GIT serves as a reservoir of ARGs , including those that confer resistance to antibiotics of critical human health significance • Antimicrobial administration frequently results in transient increases in ARGs or resistome changes, but not always. • Young calves have a higher abundance of ARGs than older cattle and represent a critical control point for focusing AMR intervention efforts. • Future work should leverage emerging technologies to better contextualize ARGs in the bovine GIT metagenome . • Studies should identify the potential non-AMD factors driving AMR in dairy and beef cattle operations in an effort find interventions. The gastrointestinal tracts of beef and dairy cattle are reservoirs of antimicrobial-resistant bacteria, and our knowledge of the ecology of resistance in these animals has changed with the advent of novel molecular technologies. Application of metagenomics and qPCR to the study of bovine gut ecology has demonstrated that there is overlap, with some differences, between beef and dairy cattle fecal resistomes, that treatment with antimicrobials often transiently influences the resistome, and young calves carry a high abundance of ARGs. Future work should harness emerging metagenome sequencing technologies to better describe the taxa harboring ARGs and collocated non-resistance genes and use these data along with identifying the multiplicity of factors driving resistance to develop strategies to reduce AMR carriage in cattle." @default.
• W3197111036 created "2021-09-13" @default.
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• W3197111036 date "2022-02-01" @default.
• W3197111036 modified "2023-09-25" @default.
• W3197111036 title "The resistome of the bovine gastrointestinal tract" @default.
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• W3197111036 doi "https://doi.org/10.1016/j.copbio.2021.07.025" @default.
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