Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197116421> ?p ?o ?g. }
- W3197116421 abstract "Transient receptor potential subfamily M member 7 (TRPM7), a mechanosensitive Ca2+ channel, plays a crucial role in intracellular Ca2+ homeostasis. However, it is currently unclear how cell mechanical cues control TRPM7 activity and its associated Ca2+ influx at plasma membrane microdomains. Using two different types of Ca2+ biosensors (Lyn-D3cpv and Kras-D3cpv) based on fluorescence resonance energy transfer, we investigate how Ca2+ influx generated by the TRPM7-specific agonist naltriben is mediated at the detergent-resistant membrane (DRM) and non-DRM regions. This study reveals that TRPM7-induced Ca2+ influx mainly occurs at the DRM, and chemically induced mechanical perturbations in the cell mechanosensitive apparatus substantially reduce Ca2+ influx through TRPM7, preferably located at the DRM. Such perturbations include the disintegration of lipid rafts, microtubules, or actomyosin filaments; the alteration of actomyosin contractility; and the inhibition of focal adhesion and Src kinases. These results suggest that the mechanical membrane environment contributes to the TRPM7 function and activity. Thus, this study provides a fundamental understanding of how the mechanical aspects of the cell membrane regulate the function of mechanosensitive channels." @default.
- W3197116421 created "2021-09-13" @default.
- W3197116421 creator A5010465785 @default.
- W3197116421 creator A5017192591 @default.
- W3197116421 creator A5018427511 @default.
- W3197116421 creator A5027167830 @default.
- W3197116421 creator A5035236012 @default.
- W3197116421 creator A5052840976 @default.
- W3197116421 creator A5053921478 @default.
- W3197116421 creator A5056471410 @default.
- W3197116421 date "2021-09-09" @default.
- W3197116421 modified "2023-09-30" @default.
- W3197116421 title "Distinct calcium regulation of TRPM7 mechanosensitive channels at plasma membrane microdomains visualized by FRET-based single cell imaging" @default.
- W3197116421 cites W1517330351 @default.
- W3197116421 cites W1542263802 @default.
- W3197116421 cites W1568617917 @default.
- W3197116421 cites W1967626349 @default.
- W3197116421 cites W1969939334 @default.
- W3197116421 cites W1977275512 @default.
- W3197116421 cites W1983879963 @default.
- W3197116421 cites W1984086927 @default.
- W3197116421 cites W1989168851 @default.
- W3197116421 cites W1993379114 @default.
- W3197116421 cites W1995496494 @default.
- W3197116421 cites W2007660746 @default.
- W3197116421 cites W2015207227 @default.
- W3197116421 cites W2016628302 @default.
- W3197116421 cites W2017549750 @default.
- W3197116421 cites W2032295238 @default.
- W3197116421 cites W2035207820 @default.
- W3197116421 cites W2048209624 @default.
- W3197116421 cites W2049430206 @default.
- W3197116421 cites W2056563854 @default.
- W3197116421 cites W2068139958 @default.
- W3197116421 cites W2086441678 @default.
- W3197116421 cites W2088473349 @default.
- W3197116421 cites W2100996687 @default.
- W3197116421 cites W2102025441 @default.
- W3197116421 cites W2113263416 @default.
- W3197116421 cites W2113304856 @default.
- W3197116421 cites W2139035695 @default.
- W3197116421 cites W2158253639 @default.
- W3197116421 cites W2158769524 @default.
- W3197116421 cites W2166241889 @default.
- W3197116421 cites W2310034942 @default.
- W3197116421 cites W2885142817 @default.
- W3197116421 cites W2901720253 @default.
- W3197116421 cites W2905253927 @default.
- W3197116421 cites W2911908266 @default.
- W3197116421 cites W2964221242 @default.
- W3197116421 cites W2979646326 @default.
- W3197116421 cites W2991312362 @default.
- W3197116421 cites W3006868374 @default.
- W3197116421 cites W3039380926 @default.
- W3197116421 doi "https://doi.org/10.1038/s41598-021-97326-z" @default.
- W3197116421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8429465" @default.
- W3197116421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34504177" @default.
- W3197116421 hasPublicationYear "2021" @default.
- W3197116421 type Work @default.
- W3197116421 sameAs 3197116421 @default.
- W3197116421 citedByCount "5" @default.
- W3197116421 countsByYear W31971164212021 @default.
- W3197116421 countsByYear W31971164212022 @default.
- W3197116421 countsByYear W31971164212023 @default.
- W3197116421 crossrefType "journal-article" @default.
- W3197116421 hasAuthorship W3197116421A5010465785 @default.
- W3197116421 hasAuthorship W3197116421A5017192591 @default.
- W3197116421 hasAuthorship W3197116421A5018427511 @default.
- W3197116421 hasAuthorship W3197116421A5027167830 @default.
- W3197116421 hasAuthorship W3197116421A5035236012 @default.
- W3197116421 hasAuthorship W3197116421A5052840976 @default.
- W3197116421 hasAuthorship W3197116421A5053921478 @default.
- W3197116421 hasAuthorship W3197116421A5056471410 @default.
- W3197116421 hasBestOaLocation W31971164211 @default.
- W3197116421 hasConcept C121332964 @default.
- W3197116421 hasConcept C12554922 @default.
- W3197116421 hasConcept C145314362 @default.
- W3197116421 hasConcept C1491633281 @default.
- W3197116421 hasConcept C155164980 @default.
- W3197116421 hasConcept C158617107 @default.
- W3197116421 hasConcept C162740809 @default.
- W3197116421 hasConcept C170493617 @default.
- W3197116421 hasConcept C185592680 @default.
- W3197116421 hasConcept C25194021 @default.
- W3197116421 hasConcept C2776610495 @default.
- W3197116421 hasConcept C2778106830 @default.
- W3197116421 hasConcept C4001165 @default.
- W3197116421 hasConcept C50254741 @default.
- W3197116421 hasConcept C53467394 @default.
- W3197116421 hasConcept C55493867 @default.
- W3197116421 hasConcept C62478195 @default.
- W3197116421 hasConcept C62520636 @default.
- W3197116421 hasConcept C79266657 @default.
- W3197116421 hasConcept C86803240 @default.
- W3197116421 hasConcept C91881484 @default.
- W3197116421 hasConcept C95444343 @default.
- W3197116421 hasConcept C96305047 @default.
- W3197116421 hasConceptScore W3197116421C121332964 @default.
- W3197116421 hasConceptScore W3197116421C12554922 @default.
- W3197116421 hasConceptScore W3197116421C145314362 @default.