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- W3197130354 abstract "Summary Although many new antiseizure drugs have been developed in the past decade, approximately 30%–40% of patients remain pharmacoresistant. There are no clinical tools or guidelines for predicting therapeutic response in individual patients, leaving them no choice other than to try all antiseizure drugs available as they suffer debilitating seizures with no relief. The discovery of predictive biomarkers and early identification of pharmacoresistant patients is of the highest priority in this group. MicroRNAs (miRNAs), a class of short noncoding RNAs negatively regulating gene expression, have emerged in recent years in epilepsy, following a broader trend of their exploitation as biomarkers of various complex human diseases. We performed a systematic search of the PubMed database for original research articles focused on miRNA expression level profiling in patients with drug‐resistant epilepsy or drug‐resistant precilinical models and cell cultures. In this review, we summarize 17 publications concerning miRNAs as potential new biomarkers of resistance to antiseizure drugs and their potential role in the development of drug resistance or epilepsy. Although numerous knowledge gaps need to be filled and reviewed, and articles share some study design pitfalls, several miRNAs dysregulated in brain tissue and blood serum were identified independently by more than one paper. These results suggest a unique opportunity for disease monitoring and personalized therapeutic management in the future." @default.
- W3197130354 created "2021-09-13" @default.
- W3197130354 creator A5023927896 @default.
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- W3197130354 creator A5090844895 @default.
- W3197130354 date "2021-09-05" @default.
- W3197130354 modified "2023-10-17" @default.
- W3197130354 title "MicroRNAs in the development of resistance to antiseizure drugs and their potential as biomarkers in pharmacoresistant epilepsy" @default.
- W3197130354 cites W1748873422 @default.
- W3197130354 cites W1783165260 @default.
- W3197130354 cites W1920696238 @default.
- W3197130354 cites W1958284284 @default.
- W3197130354 cites W1963952972 @default.
- W3197130354 cites W1965306643 @default.
- W3197130354 cites W1978672997 @default.
- W3197130354 cites W1978720299 @default.
- W3197130354 cites W1979405589 @default.
- W3197130354 cites W1983949013 @default.
- W3197130354 cites W1991544505 @default.
- W3197130354 cites W1995751132 @default.
- W3197130354 cites W2003439788 @default.
- W3197130354 cites W2020596227 @default.
- W3197130354 cites W2021489157 @default.
- W3197130354 cites W2024206172 @default.
- W3197130354 cites W2025978099 @default.
- W3197130354 cites W2026570544 @default.
- W3197130354 cites W2030070077 @default.
- W3197130354 cites W2031498856 @default.
- W3197130354 cites W2036844214 @default.
- W3197130354 cites W2038680426 @default.
- W3197130354 cites W2039578096 @default.
- W3197130354 cites W2041252857 @default.
- W3197130354 cites W2041366549 @default.
- W3197130354 cites W2041726259 @default.
- W3197130354 cites W2043773337 @default.
- W3197130354 cites W2044088017 @default.
- W3197130354 cites W2048065948 @default.
- W3197130354 cites W2052985891 @default.
- W3197130354 cites W2060481603 @default.
- W3197130354 cites W2060755559 @default.
- W3197130354 cites W2061928059 @default.
- W3197130354 cites W2063796705 @default.
- W3197130354 cites W2066124024 @default.
- W3197130354 cites W2072653162 @default.
- W3197130354 cites W2078812502 @default.
- W3197130354 cites W2089278672 @default.
- W3197130354 cites W2100809769 @default.
- W3197130354 cites W2105679485 @default.
- W3197130354 cites W2118883717 @default.
- W3197130354 cites W2119604948 @default.
- W3197130354 cites W2121079193 @default.
- W3197130354 cites W2126487804 @default.
- W3197130354 cites W2137179072 @default.
- W3197130354 cites W2138473891 @default.
- W3197130354 cites W2141138739 @default.
- W3197130354 cites W2141549067 @default.
- W3197130354 cites W2146519879 @default.
- W3197130354 cites W2156900818 @default.
- W3197130354 cites W2157057083 @default.
- W3197130354 cites W2159136339 @default.
- W3197130354 cites W2161456882 @default.
- W3197130354 cites W2165792011 @default.
- W3197130354 cites W2169006271 @default.
- W3197130354 cites W2171296186 @default.
- W3197130354 cites W2259537051 @default.
- W3197130354 cites W2261997464 @default.
- W3197130354 cites W2265544237 @default.
- W3197130354 cites W2292908037 @default.
- W3197130354 cites W2342857294 @default.
- W3197130354 cites W2418807401 @default.
- W3197130354 cites W2516591823 @default.
- W3197130354 cites W2516618401 @default.
- W3197130354 cites W2521883852 @default.
- W3197130354 cites W2553245189 @default.
- W3197130354 cites W2559858524 @default.
- W3197130354 cites W2561722651 @default.
- W3197130354 cites W2592393805 @default.
- W3197130354 cites W2604750655 @default.
- W3197130354 cites W2622309966 @default.
- W3197130354 cites W2730325637 @default.
- W3197130354 cites W2748904327 @default.
- W3197130354 cites W2750496862 @default.
- W3197130354 cites W2751861194 @default.
- W3197130354 cites W2757318787 @default.
- W3197130354 cites W2761267249 @default.
- W3197130354 cites W2775542575 @default.
- W3197130354 cites W2782032233 @default.
- W3197130354 cites W2792282260 @default.
- W3197130354 cites W2801028794 @default.
- W3197130354 cites W2802489719 @default.
- W3197130354 cites W2808496637 @default.
- W3197130354 cites W2883829150 @default.
- W3197130354 cites W2894930186 @default.
- W3197130354 cites W2896435368 @default.
- W3197130354 cites W2909985059 @default.