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- W3197145747 abstract "The pandemic of the coronavirus disease 2019 (COVID-19) has posed huge threats to healthcare systems and the global economy. However, the host response towards COVID-19 on the molecular and cellular levels still lacks full understanding and effective therapies are in urgent need. Here, we integrate three datasets, GSE152641, GSE161777, and GSE157103. Compared to healthy people, 314 differentially expressed genes were identified, which were mostly involved in neutrophil degranulation and cell division. The protein-protein network was established and two significant subsets were filtered by MCODE: ssGSEA and CIBERSORT, which comprehensively revealed the alternation of immune cell abundance. Weighted gene coexpression network analysis (WGCNA) as well as GO and KEGG analyses unveiled the role of neutrophils and T cells during the progress of the disease. Based on the hospital-free days after 45 days of follow-up and statistical methods such as nonnegative matrix factorization (NMF), submap, and linear correlation analysis, 31 genes were regarded as the signature of the peripheral blood of COVID-19. Various immune cells were identified to be related to the prognosis of the patients. Drugs were predicted for the genes in the signature by DGIdb. Overall, our study comprehensively revealed the relationship between the inflammatory response and the disease course, which provided strategies for the treatment of COVID-19." @default.
- W3197145747 created "2021-09-13" @default.
- W3197145747 creator A5011731170 @default.
- W3197145747 creator A5026885379 @default.
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- W3197145747 creator A5059046810 @default.
- W3197145747 creator A5063046834 @default.
- W3197145747 date "2021-08-26" @default.
- W3197145747 modified "2023-09-30" @default.
- W3197145747 title "Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID-19" @default.
- W3197145747 cites W1911311114 @default.
- W3197145747 cites W1966327575 @default.
- W3197145747 cites W1969934334 @default.
- W3197145747 cites W1972493493 @default.
- W3197145747 cites W1985987855 @default.
- W3197145747 cites W1993257138 @default.
- W3197145747 cites W1993371758 @default.
- W3197145747 cites W2001822779 @default.
- W3197145747 cites W2011964798 @default.
- W3197145747 cites W2017662994 @default.
- W3197145747 cites W2035618305 @default.
- W3197145747 cites W2047178318 @default.
- W3197145747 cites W2047802142 @default.
- W3197145747 cites W2048237213 @default.
- W3197145747 cites W2050345155 @default.
- W3197145747 cites W2069440689 @default.
- W3197145747 cites W2071957953 @default.
- W3197145747 cites W2074312528 @default.
- W3197145747 cites W2096173332 @default.
- W3197145747 cites W2102395431 @default.
- W3197145747 cites W2109830821 @default.
- W3197145747 cites W2114104545 @default.
- W3197145747 cites W2124309131 @default.
- W3197145747 cites W2135423586 @default.
- W3197145747 cites W2136850043 @default.
- W3197145747 cites W2137526110 @default.
- W3197145747 cites W2146434647 @default.
- W3197145747 cites W2147328758 @default.
- W3197145747 cites W2159675211 @default.
- W3197145747 cites W2159707944 @default.
- W3197145747 cites W2164209124 @default.
- W3197145747 cites W2471199181 @default.
- W3197145747 cites W2471456962 @default.
- W3197145747 cites W2606854438 @default.
- W3197145747 cites W2762816177 @default.
- W3197145747 cites W2763349329 @default.
- W3197145747 cites W2768474790 @default.
- W3197145747 cites W2795979817 @default.
- W3197145747 cites W2894451493 @default.
- W3197145747 cites W2896823861 @default.
- W3197145747 cites W2918091949 @default.
- W3197145747 cites W2949273159 @default.
- W3197145747 cites W2949486591 @default.
- W3197145747 cites W2950595506 @default.
- W3197145747 cites W2950753203 @default.
- W3197145747 cites W2966604413 @default.
- W3197145747 cites W2966919335 @default.
- W3197145747 cites W2969810988 @default.
- W3197145747 cites W3005347918 @default.
- W3197145747 cites W3009314935 @default.
- W3197145747 cites W3009859788 @default.
- W3197145747 cites W3010441732 @default.
- W3197145747 cites W3011134208 @default.
- W3197145747 cites W3011623493 @default.
- W3197145747 cites W3012421327 @default.
- W3197145747 cites W3012655019 @default.
- W3197145747 cites W3013270782 @default.
- W3197145747 cites W3013694267 @default.
- W3197145747 cites W3013814476 @default.
- W3197145747 cites W3015740499 @default.
- W3197145747 cites W3016489853 @default.
- W3197145747 cites W3023991776 @default.
- W3197145747 cites W3024643080 @default.
- W3197145747 cites W3025232799 @default.
- W3197145747 cites W3025312761 @default.
- W3197145747 cites W3026977107 @default.
- W3197145747 cites W3028322703 @default.
- W3197145747 cites W3029648091 @default.
- W3197145747 cites W3030833760 @default.
- W3197145747 cites W3031456278 @default.
- W3197145747 cites W3034168389 @default.
- W3197145747 cites W3037222683 @default.
- W3197145747 cites W3038048336 @default.
- W3197145747 cites W3038261609 @default.
- W3197145747 cites W3042953157 @default.
- W3197145747 cites W3043029189 @default.
- W3197145747 cites W3045927404 @default.
- W3197145747 cites W3047014743 @default.
- W3197145747 cites W3047880178 @default.
- W3197145747 cites W3048884493 @default.
- W3197145747 cites W3080981445 @default.
- W3197145747 cites W3086293749 @default.
- W3197145747 cites W3091839106 @default.
- W3197145747 cites W3092519469 @default.
- W3197145747 cites W3107765474 @default.
- W3197145747 cites W3108714922 @default.
- W3197145747 cites W3108961313 @default.