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- W3197148897 abstract "We used two-photon microscopy to examine calcium influx induced by action potentials in cortical pyramidal neurons from a mouse model of Huntington’s disease (HD), the R6/2. The amplitude of somatic calcium transients was reduced in R6/2 mice compared with controls. This reduction was compensated by increased decay times, which could lead to reduced calcium buffering capacity. L-type calcium channel and ryanodine receptor blockers reduced calcium transient area in HD neurons, suggesting new therapeutic avenues." @default.
- W3197148897 created "2021-09-13" @default.
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- W3197148897 date "2021-10-01" @default.
- W3197148897 modified "2023-09-26" @default.
- W3197148897 title "Calcium dysregulation and compensation in cortical pyramidal neurons of the R6/2 mouse model of Huntington’s disease" @default.
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- W3197148897 doi "https://doi.org/10.1152/jn.00181.2021" @default.
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