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• W3197170229 abstract "Neuronal communication is typically mediated via synapses and gap junctions. New forms of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs), have been described for non-neuronal cells, but their role in neuronal communication is not known. Recently, transfer of cytoplasmic material between donor and host neurons (material transfer) was shown to occur after photoreceptor transplantation. The cellular mechanism(s) underlying this surprising finding are unknown. Here, using transplantation, primary neuronal cultures and the generation of chimeric retinae, we show for the first time that mammalian photoreceptor neurons can form open-end NT-like processes. These processes permit the transfer of cytoplasmic and membrane-bound molecules in culture and after transplantation and can mediate gain-of-function in the acceptor cells. Rarely, organelles were also observed to transfer. Strikingly, use of chimeric retinae revealed that material transfer can occur between photoreceptors in the intact adult retina. Conversely, while photoreceptors are capable of releasing EVs, at least in culture, these are taken up by glia and not by retinal neurons. Our findings provide the first evidence of functional NT-like processes forming between sensory neurons in culture and in vivo." @default.
• W3197170229 created "2021-09-13" @default.
• W3197170229 creator A5004844980 @default.
• W3197170229 creator A5010114740 @default.
• W3197170229 creator A5016769331 @default.
• W3197170229 creator A5020224090 @default.
• W3197170229 creator A5044444767 @default.
• W3197170229 creator A5073699632 @default.
• W3197170229 creator A5086299766 @default.
• W3197170229 date "2021-09-08" @default.
• W3197170229 modified "2023-10-14" @default.
• W3197170229 title "Nanotube‐like processes facilitate material transfer between photoreceptors" @default.
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