FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197181162> ?p ?o ?g. }

• W3197181162 abstract "Introduction: The gastrointestinal malignancy, gastric cancer (GC), has a high incidence worldwide. Cisplatin is a traditional chemotherapeutic drug that is generally applied to treat cancer; however, drug tolerance affects its efficacy. Sodium butyrate is an intestinal flora derivative that has general anti-cancer effects in vitro and in vivo via pro-apoptosis effects and can improve prognosis in combination with traditional chemotherapy drugs. The present study aimed to assess the effect of sodium butyrate combined with cisplatin on GC. Methods: A Cell Counting Kit-8 assay was used to assess the viability of GC cells in vitro. Hoechst 33,258 staining and Annexin V-Phycoerythrin/7-Aminoactinomycin D were used to qualitatively and quantitatively detect apoptosis in GC cells. Intracellular reactive oxygen species (ROS) measurement and a mitochondrial membrane potential (MMP) assay kit were used to qualitatively and quantitatively reflect the function of mitochondria in GC cells. Western blotting was used to verify the above experimental results. A nude mouse xenograft tumor model was used to evaluate the anti-tumor efficacity of sodium and cisplatin butyrate in vivo. Results: Cisplatin combined with sodium butyrate increased the apoptosis of GC cells. In the nude mouse xenograft tumor model, sodium butyrate in combination with cisplatin markedly inhibited the growth of the tumor more effectively than either single agent. The combination of sodium butyrate and cisplatin increased the intracellular ROS, decreased the MMP, and suppressed the invasion and migration abilities of GC cells. Western blotting verified that the combination of sodium butyrate and cisplatin remarkably enhanced the levels of mitochondrial apoptosis-related pathway proteins. Conclusion: Sodium butyrate, a histone acetylation inhibitor produced by intestinal flora fermentation, combined with cisplatin enhanced the apoptosis of GC cells through the mitochondrial apoptosis-related pathway, which might be considered as a therapeutic option for GC." @default.
• W3197181162 created "2021-09-13" @default.
• W3197181162 creator A5041323907 @default.
• W3197181162 creator A5050212741 @default.
• W3197181162 creator A5057813342 @default.
• W3197181162 creator A5057948360 @default.
• W3197181162 creator A5068466105 @default.
• W3197181162 date "2021-08-27" @default.
• W3197181162 modified "2023-10-05" @default.
• W3197181162 title "Combining Sodium Butyrate With Cisplatin Increases the Apoptosis of Gastric Cancer In Vivo and In Vitro via the Mitochondrial Apoptosis Pathway" @default.
• W3197181162 cites W1515288366 @default.
• W3197181162 cites W1991233540 @default.
• W3197181162 cites W2013745495 @default.
• W3197181162 cites W2018983995 @default.
• W3197181162 cites W2035255389 @default.
• W3197181162 cites W2059837772 @default.
• W3197181162 cites W2120394513 @default.
• W3197181162 cites W2214858649 @default.
• W3197181162 cites W2345712655 @default.
• W3197181162 cites W2497578365 @default.
• W3197181162 cites W2591627715 @default.
• W3197181162 cites W2625806186 @default.
• W3197181162 cites W2735126203 @default.
• W3197181162 cites W2765113361 @default.
• W3197181162 cites W2797197823 @default.
• W3197181162 cites W2870351107 @default.
• W3197181162 cites W2889101189 @default.
• W3197181162 cites W2901847905 @default.
• W3197181162 cites W2909304876 @default.
• W3197181162 cites W2913914265 @default.
• W3197181162 cites W2921170434 @default.
• W3197181162 cites W2942394079 @default.
• W3197181162 cites W2943746329 @default.
• W3197181162 cites W2949432489 @default.
• W3197181162 cites W2971172765 @default.
• W3197181162 cites W2977680707 @default.
• W3197181162 cites W2987737889 @default.
• W3197181162 cites W3002882027 @default.
• W3197181162 cites W3011979387 @default.
• W3197181162 cites W3012285865 @default.
• W3197181162 cites W3022746266 @default.
• W3197181162 cites W3025851960 @default.
• W3197181162 cites W3030169800 @default.
• W3197181162 cites W3082741996 @default.
• W3197181162 cites W3128646645 @default.
• W3197181162 cites W3128802929 @default.
• W3197181162 doi "https://doi.org/10.3389/fphar.2021.708093" @default.
• W3197181162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8430036" @default.
• W3197181162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34512341" @default.
• W3197181162 hasPublicationYear "2021" @default.
• W3197181162 type Work @default.
• W3197181162 sameAs 3197181162 @default.
• W3197181162 citedByCount "15" @default.
• W3197181162 countsByYear W31971811622022 @default.
• W3197181162 countsByYear W31971811622023 @default.
• W3197181162 crossrefType "journal-article" @default.
• W3197181162 hasAuthorship W3197181162A5041323907 @default.
• W3197181162 hasAuthorship W3197181162A5050212741 @default.
• W3197181162 hasAuthorship W3197181162A5057813342 @default.
• W3197181162 hasAuthorship W3197181162A5057948360 @default.
• W3197181162 hasAuthorship W3197181162A5068466105 @default.
• W3197181162 hasBestOaLocation W31971811621 @default.
• W3197181162 hasConcept C100544194 @default.
• W3197181162 hasConcept C104317684 @default.
• W3197181162 hasConcept C121608353 @default.
• W3197181162 hasConcept C150903083 @default.
• W3197181162 hasConcept C153911025 @default.
• W3197181162 hasConcept C185592680 @default.
• W3197181162 hasConcept C190283241 @default.
• W3197181162 hasConcept C207001950 @default.
• W3197181162 hasConcept C2776694085 @default.
• W3197181162 hasConcept C2776979534 @default.
• W3197181162 hasConcept C2778239845 @default.
• W3197181162 hasConcept C2778942008 @default.
• W3197181162 hasConcept C502942594 @default.
• W3197181162 hasConcept C53227056 @default.
• W3197181162 hasConcept C54355233 @default.
• W3197181162 hasConcept C55493867 @default.
• W3197181162 hasConcept C86803240 @default.
• W3197181162 hasConcept C88634738 @default.
• W3197181162 hasConcept C96232424 @default.
• W3197181162 hasConcept C98274493 @default.
• W3197181162 hasConceptScore W3197181162C100544194 @default.
• W3197181162 hasConceptScore W3197181162C104317684 @default.
• W3197181162 hasConceptScore W3197181162C121608353 @default.
• W3197181162 hasConceptScore W3197181162C150903083 @default.
• W3197181162 hasConceptScore W3197181162C153911025 @default.
• W3197181162 hasConceptScore W3197181162C185592680 @default.
• W3197181162 hasConceptScore W3197181162C190283241 @default.
• W3197181162 hasConceptScore W3197181162C207001950 @default.
• W3197181162 hasConceptScore W3197181162C2776694085 @default.
• W3197181162 hasConceptScore W3197181162C2776979534 @default.
• W3197181162 hasConceptScore W3197181162C2778239845 @default.
• W3197181162 hasConceptScore W3197181162C2778942008 @default.
• W3197181162 hasConceptScore W3197181162C502942594 @default.
• W3197181162 hasConceptScore W3197181162C53227056 @default.
• W3197181162 hasConceptScore W3197181162C54355233 @default.
• W3197181162 hasConceptScore W3197181162C55493867 @default.
• W3197181162 hasConceptScore W3197181162C86803240 @default.
• W3197181162 hasConceptScore W3197181162C88634738 @default.

• next