Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197230147> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3197230147 abstract "<h3>Background</h3> Huntington’s Disease (HD) is a devastating and presently untreatable neurodegenerative disease, characterized by progressively disabling motor and mental manifestations. Sigma-1 receptor (σ1R), whose 3D structure has been recently determined by X-ray crystallography, is expressed in the central nervous system, and σ1R agonists have been shown to possess neuroprotective activity in neurodegenerative diseases. <h3>Aims</h3> Our overall aim is to exploit σ1R neuroprotective activity for HD therapy. <h3>Methods</h3> We are integrating computational and experimental methods: i) Virtual Screening (VS) of compound libraries available through the ZINC database towards σ1R; ii) Experimental ligand binding to purified σ1R in vitro by Surface Plasmon Resonance; iii) Assessment of ligand ability to improve the growth of fibroblasts obtained from HD patients, which is significantly impaired with respect to control cells. Additionally, we are performing Molecular Dynamics (MD) simulations to elucidate the mechanism of ligand entrance to σ1R binding site. <h3>Results</h3> i) Six known drugs have been demonstrated to be able to bind purified σ1R in vitro and improve survival and growth of HD fibroblasts; ii) Several human metabolites have been predicted by VS to bind σ1R. iii) Predictions on routes of ligand entrance have been provided by MD studies. <h3>Conclusions</h3> Our results support the validity of σ1R as a molecular target for HD therapy, and of the drug repositioning procedure implemented herein for the identification of new therapeutic agents against HD. Experimental validation of metabolites selected by VS and results of MD simulations will contribute to identify endogenous σ1R ligand(s) and mechanism of σ1R entrance." @default.
- W3197230147 created "2021-09-13" @default.
- W3197230147 creator A5000267232 @default.
- W3197230147 creator A5002796232 @default.
- W3197230147 creator A5004005837 @default.
- W3197230147 creator A5007685206 @default.
- W3197230147 creator A5013512498 @default.
- W3197230147 creator A5060832175 @default.
- W3197230147 creator A5071863016 @default.
- W3197230147 creator A5079834670 @default.
- W3197230147 creator A5081679633 @default.
- W3197230147 creator A5087956207 @default.
- W3197230147 date "2021-09-01" @default.
- W3197230147 modified "2023-09-25" @default.
- W3197230147 title "I12 Deciphering the neuroprotective role of sigma1 receptor, an important function to overcome the symptoms of neurodegenerative disorders" @default.
- W3197230147 doi "https://doi.org/10.1136/jnnp-2021-ehdn.126" @default.
- W3197230147 hasPublicationYear "2021" @default.
- W3197230147 type Work @default.
- W3197230147 sameAs 3197230147 @default.
- W3197230147 citedByCount "0" @default.
- W3197230147 crossrefType "proceedings-article" @default.
- W3197230147 hasAuthorship W3197230147A5000267232 @default.
- W3197230147 hasAuthorship W3197230147A5002796232 @default.
- W3197230147 hasAuthorship W3197230147A5004005837 @default.
- W3197230147 hasAuthorship W3197230147A5007685206 @default.
- W3197230147 hasAuthorship W3197230147A5013512498 @default.
- W3197230147 hasAuthorship W3197230147A5060832175 @default.
- W3197230147 hasAuthorship W3197230147A5071863016 @default.
- W3197230147 hasAuthorship W3197230147A5079834670 @default.
- W3197230147 hasAuthorship W3197230147A5081679633 @default.
- W3197230147 hasAuthorship W3197230147A5087956207 @default.
- W3197230147 hasBestOaLocation W31972301471 @default.
- W3197230147 hasConcept C103697762 @default.
- W3197230147 hasConcept C106847996 @default.
- W3197230147 hasConcept C116569031 @default.
- W3197230147 hasConcept C155672457 @default.
- W3197230147 hasConcept C169760540 @default.
- W3197230147 hasConcept C170493617 @default.
- W3197230147 hasConcept C171250308 @default.
- W3197230147 hasConcept C185592680 @default.
- W3197230147 hasConcept C192562407 @default.
- W3197230147 hasConcept C202751555 @default.
- W3197230147 hasConcept C25498285 @default.
- W3197230147 hasConcept C55493867 @default.
- W3197230147 hasConcept C70721500 @default.
- W3197230147 hasConcept C71924100 @default.
- W3197230147 hasConcept C74187038 @default.
- W3197230147 hasConcept C86803240 @default.
- W3197230147 hasConcept C95444343 @default.
- W3197230147 hasConcept C98274493 @default.
- W3197230147 hasConceptScore W3197230147C103697762 @default.
- W3197230147 hasConceptScore W3197230147C106847996 @default.
- W3197230147 hasConceptScore W3197230147C116569031 @default.
- W3197230147 hasConceptScore W3197230147C155672457 @default.
- W3197230147 hasConceptScore W3197230147C169760540 @default.
- W3197230147 hasConceptScore W3197230147C170493617 @default.
- W3197230147 hasConceptScore W3197230147C171250308 @default.
- W3197230147 hasConceptScore W3197230147C185592680 @default.
- W3197230147 hasConceptScore W3197230147C192562407 @default.
- W3197230147 hasConceptScore W3197230147C202751555 @default.
- W3197230147 hasConceptScore W3197230147C25498285 @default.
- W3197230147 hasConceptScore W3197230147C55493867 @default.
- W3197230147 hasConceptScore W3197230147C70721500 @default.
- W3197230147 hasConceptScore W3197230147C71924100 @default.
- W3197230147 hasConceptScore W3197230147C74187038 @default.
- W3197230147 hasConceptScore W3197230147C86803240 @default.
- W3197230147 hasConceptScore W3197230147C95444343 @default.
- W3197230147 hasConceptScore W3197230147C98274493 @default.
- W3197230147 hasLocation W31972301471 @default.
- W3197230147 hasOpenAccess W3197230147 @default.
- W3197230147 hasPrimaryLocation W31972301471 @default.
- W3197230147 hasRelatedWork W120026478 @default.
- W3197230147 hasRelatedWork W1714666523 @default.
- W3197230147 hasRelatedWork W2060171382 @default.
- W3197230147 hasRelatedWork W2071791280 @default.
- W3197230147 hasRelatedWork W2092688629 @default.
- W3197230147 hasRelatedWork W2906621212 @default.
- W3197230147 hasRelatedWork W2960482952 @default.
- W3197230147 hasRelatedWork W4200127861 @default.
- W3197230147 hasRelatedWork W4304191862 @default.
- W3197230147 hasRelatedWork W4309150917 @default.
- W3197230147 isParatext "false" @default.
- W3197230147 isRetracted "false" @default.
- W3197230147 magId "3197230147" @default.
- W3197230147 workType "article" @default.