Matches in SemOpenAlex for { <https://semopenalex.org/work/W3197246549> ?p ?o ?g. }
- W3197246549 endingPage "1722" @default.
- W3197246549 startingPage "1703" @default.
- W3197246549 abstract "A well-known medicinal mushroom in the field of traditional Chinese medicine, Cordyceps sinensis, is a rare natural-occurring entomopathogenic fungus, and it typically grows at high altitudes on the plateau of the Himalayan. Previous studies indicated that cordycepin, the main bioactive chemical of Cordyceps sinensis, has very potent anticancer, anti-oxidant and anti-inflammatory activities. However, its protective effects against atherosclerotic changes in vascular endothelial cells have not been fully elucidated. In this study, we showed that pretreatment with cordycepin significantly attenuated palmitic acid (PA)-induced cytotoxicity, reactive oxygen species (ROS) generation, and inflammatory responses. We found that PA decreased phosphorylation of Akt, eNOS, and bioavailability of nitric oxide (NO), which in turn activated NF-[Formula: see text]B and the downstream inflammatory responses. All these detrimental events were markedly blocked by pretreatment with cordycepin. Moreover, cordycepin ameliorated destabilization of mitochondrial permeability, cytosolic calcium rises, and apoptotic features caused by PA. In addition, all these anti-inflammatory and anti-apoptosis effects of cordycepin were found to be inhibited by the PI3K and eNOS inhibitor, suggesting that its anti-atherosclerotic effects may partially be mediated by the PI3K/Akt/eNOS signaling pathway." @default.
- W3197246549 created "2021-09-13" @default.
- W3197246549 creator A5000512140 @default.
- W3197246549 creator A5014505767 @default.
- W3197246549 creator A5025617602 @default.
- W3197246549 creator A5072772669 @default.
- W3197246549 creator A5079367503 @default.
- W3197246549 creator A5080983679 @default.
- W3197246549 date "2021-01-01" @default.
- W3197246549 modified "2023-10-13" @default.
- W3197246549 title "Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway" @default.
- W3197246549 cites W1540820582 @default.
- W3197246549 cites W1763305594 @default.
- W3197246549 cites W1984053793 @default.
- W3197246549 cites W1988003144 @default.
- W3197246549 cites W2012466721 @default.
- W3197246549 cites W2015310103 @default.
- W3197246549 cites W2020316460 @default.
- W3197246549 cites W2023633834 @default.
- W3197246549 cites W2024438199 @default.
- W3197246549 cites W2030263715 @default.
- W3197246549 cites W2030449305 @default.
- W3197246549 cites W2032599628 @default.
- W3197246549 cites W2037165324 @default.
- W3197246549 cites W2049186934 @default.
- W3197246549 cites W2053968155 @default.
- W3197246549 cites W2057818411 @default.
- W3197246549 cites W2063385957 @default.
- W3197246549 cites W2075082531 @default.
- W3197246549 cites W2076503506 @default.
- W3197246549 cites W2077925758 @default.
- W3197246549 cites W2094237674 @default.
- W3197246549 cites W2126203280 @default.
- W3197246549 cites W2152531256 @default.
- W3197246549 cites W2461561430 @default.
- W3197246549 cites W2769197730 @default.
- W3197246549 cites W2886814696 @default.
- W3197246549 cites W2891948353 @default.
- W3197246549 cites W2919258702 @default.
- W3197246549 cites W2952198326 @default.
- W3197246549 cites W2982467793 @default.
- W3197246549 cites W3033636653 @default.
- W3197246549 cites W3042855549 @default.
- W3197246549 cites W3084965219 @default.
- W3197246549 cites W3089744246 @default.
- W3197246549 cites W3093022522 @default.
- W3197246549 cites W3111229084 @default.
- W3197246549 cites W3114285923 @default.
- W3197246549 cites W3116657859 @default.
- W3197246549 cites W3119774972 @default.
- W3197246549 cites W3121936045 @default.
- W3197246549 cites W3123719889 @default.
- W3197246549 doi "https://doi.org/10.1142/s0192415x21500804" @default.
- W3197246549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34488549" @default.
- W3197246549 hasPublicationYear "2021" @default.
- W3197246549 type Work @default.
- W3197246549 sameAs 3197246549 @default.
- W3197246549 citedByCount "6" @default.
- W3197246549 countsByYear W31972465492022 @default.
- W3197246549 countsByYear W31972465492023 @default.
- W3197246549 crossrefType "journal-article" @default.
- W3197246549 hasAuthorship W3197246549A5000512140 @default.
- W3197246549 hasAuthorship W3197246549A5014505767 @default.
- W3197246549 hasAuthorship W3197246549A5025617602 @default.
- W3197246549 hasAuthorship W3197246549A5072772669 @default.
- W3197246549 hasAuthorship W3197246549A5079367503 @default.
- W3197246549 hasAuthorship W3197246549A5080983679 @default.
- W3197246549 hasConcept C178790620 @default.
- W3197246549 hasConcept C185592680 @default.
- W3197246549 hasConcept C190283241 @default.
- W3197246549 hasConcept C2777622882 @default.
- W3197246549 hasConcept C2778326061 @default.
- W3197246549 hasConcept C2779085617 @default.
- W3197246549 hasConcept C2780066241 @default.
- W3197246549 hasConcept C31903555 @default.
- W3197246549 hasConcept C48349386 @default.
- W3197246549 hasConcept C519581460 @default.
- W3197246549 hasConcept C55493867 @default.
- W3197246549 hasConcept C75217442 @default.
- W3197246549 hasConcept C86554907 @default.
- W3197246549 hasConcept C86803240 @default.
- W3197246549 hasConcept C98274493 @default.
- W3197246549 hasConceptScore W3197246549C178790620 @default.
- W3197246549 hasConceptScore W3197246549C185592680 @default.
- W3197246549 hasConceptScore W3197246549C190283241 @default.
- W3197246549 hasConceptScore W3197246549C2777622882 @default.
- W3197246549 hasConceptScore W3197246549C2778326061 @default.
- W3197246549 hasConceptScore W3197246549C2779085617 @default.
- W3197246549 hasConceptScore W3197246549C2780066241 @default.
- W3197246549 hasConceptScore W3197246549C31903555 @default.
- W3197246549 hasConceptScore W3197246549C48349386 @default.
- W3197246549 hasConceptScore W3197246549C519581460 @default.
- W3197246549 hasConceptScore W3197246549C55493867 @default.
- W3197246549 hasConceptScore W3197246549C75217442 @default.
- W3197246549 hasConceptScore W3197246549C86554907 @default.
- W3197246549 hasConceptScore W3197246549C86803240 @default.
- W3197246549 hasConceptScore W3197246549C98274493 @default.
- W3197246549 hasFunder F4320322795 @default.