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• W3197252110 abstract "Distal-less homeobox-1 (DLX1) is a well-established non-invasive biomarker for prostate cancer (PCa) diagnosis, however, its mechanistic underpinnings in disease pathobiology are not known. Here, we reveal the oncogenic role of DLX1 and show that abrogating its function leads to reduced tumorigenesis and metastases. We observed that ~60% of advanced-stage and metastatic patients display higher DLX1 levels. Moreover, ~96% of TMPRSS2-ERG fusion-positive and ~70% of androgen receptor (AR)-positive patients show elevated DLX1, associated with aggressive disease and poor survival. Mechanistically, ERG coordinates with enhancer-bound AR and FOXA1 to drive transcriptional upregulation of DLX1 in ERG-positive background. However, in ERG-negative context, AR/AR-V7 and FOXA1 suffice to upregulate DLX1. Notably, inhibiting ERG/AR-mediated DLX1 transcription using BET inhibitor (BETi) or/and anti-androgen drugs reduce its expression and downstream oncogenic effects. Conclusively, this study establishes DLX1 as a direct-target of ERG/AR with an oncogenic role and demonstrates the clinical significance of BETi and anti-androgens for DLX1-positive patients." @default.
• W3197252110 created "2021-09-13" @default.
• W3197252110 creator A5005827657 @default.
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• W3197252110 creator A5090530793 @default.
• W3197252110 date "2021-09-07" @default.
• W3197252110 modified "2023-10-11" @default.
• W3197252110 title "Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression" @default.
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• W3197252110 cites W1951061860 @default.
• W3197252110 cites W2007054651 @default.
• W3197252110 cites W2009109655 @default.
• W3197252110 cites W2012619882 @default.
• W3197252110 cites W2016191016 @default.
• W3197252110 cites W2017839954 @default.
• W3197252110 cites W2021341670 @default.
• W3197252110 cites W2029575024 @default.
• W3197252110 cites W2033439599 @default.
• W3197252110 cites W2034829050 @default.
• W3197252110 cites W2040672147 @default.
• W3197252110 cites W2051025382 @default.
• W3197252110 cites W2066171378 @default.
• W3197252110 cites W2066326124 @default.
• W3197252110 cites W2078455244 @default.
• W3197252110 cites W2079298594 @default.
• W3197252110 cites W2089518544 @default.
• W3197252110 cites W2090352577 @default.
• W3197252110 cites W2097226696 @default.
• W3197252110 cites W2106779749 @default.
• W3197252110 cites W2107633226 @default.
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• W3197252110 cites W2126496338 @default.
• W3197252110 cites W2130410032 @default.
• W3197252110 cites W2141077390 @default.
• W3197252110 cites W2141198558 @default.
• W3197252110 cites W2141719485 @default.
• W3197252110 cites W2142320568 @default.
• W3197252110 cites W2147660153 @default.
• W3197252110 cites W2152516668 @default.
• W3197252110 cites W2153052749 @default.
• W3197252110 cites W2156923287 @default.
• W3197252110 cites W2158217645 @default.
• W3197252110 cites W2159675211 @default.
• W3197252110 cites W2161112598 @default.
• W3197252110 cites W2181283187 @default.
• W3197252110 cites W2220221033 @default.
• W3197252110 cites W2268281268 @default.
• W3197252110 cites W2276370059 @default.
• W3197252110 cites W2334656801 @default.
• W3197252110 cites W2341689870 @default.
• W3197252110 cites W2404409977 @default.
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• W3197252110 cites W2603336551 @default.
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• W3197252110 cites W2779743226 @default.
• W3197252110 cites W2782333160 @default.
• W3197252110 cites W2782440128 @default.
• W3197252110 cites W2806280499 @default.
• W3197252110 cites W2885945442 @default.
• W3197252110 cites W2887980079 @default.
• W3197252110 cites W2894309168 @default.
• W3197252110 cites W2895496651 @default.
• W3197252110 cites W2906525193 @default.
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• W3197252110 doi "https://doi.org/10.1038/s41467-021-25623-2" @default.
• W3197252110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8423767" @default.
• W3197252110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34493733" @default.
• W3197252110 hasPublicationYear "2021" @default.
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