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- W3197256002 abstract "Abstract Molecular chaperones, including Hsp70/J-domain protein (JDP) families, play central roles in binding substrates to prevent their aggregation. How JDPs select different conformations of substrates remains poorly understood. Here, we report an interaction between the JDP DnaJC7 and tau that efficiently suppresses tau aggregation in vitro and in cells. DnaJC7 binds preferentially to natively folded wild-type tau, but disease-associated mutants in tau reduce chaperone binding affinity. We identify that DnaJC7 uses a single TPR domain to recognize a β-turn structural element in tau that contains the 275 VQIINK 280 amyloid motif. Wild-type tau, but not mutant, β-turn structural elements can block full-length tau binding to DnaJC7. These data suggest DnaJC7 preferentially binds and stabilizes natively folded conformations of tau to prevent tau conversion into amyloids. Our work identifies a novel mechanism of tau aggregation regulation that can be exploited as both a diagnostic and a therapeutic intervention." @default.
- W3197256002 created "2021-09-13" @default.
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- W3197256002 date "2021-09-09" @default.
- W3197256002 modified "2023-10-18" @default.
- W3197256002 title "DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation" @default.
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- W3197256002 doi "https://doi.org/10.1038/s41467-021-25635-y" @default.
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