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- W3197268249 abstract "Deregulation of synaptic function and neurotransmission has been linked with the development of major depression disorder (MDD). Tianeptine (Tian) has been used as antidepressant with anxiolytic properties and recently as a nootropic to improve cognitive performance, but its mechanism of action is unknown. We conducted a proteomic study on the hippocampal synaptosomal fractions of adult male Wistar rats exposed to chronic social isolation (CSIS, 6 weeks), an animal model of depression and after chronic Tian treatment in controls (nootropic effect) and CSIS-exposed rats (lasting 3 weeks of 6-week CSIS) (therapeutic effect). Increased expression of Syn1 and Camk2-related neurotransmission, vesicle transport and energy processes in Tian-treated controls were found. CSIS led to upregulation of proteins associated with actin cytoskeleton, signaling transduction and glucose metabolism. In CSIS rats, Tian up-regulated proteins involved in mitochondrial energy production, mitochondrial transport and dynamics, antioxidative defense and glutamate clearance, while attenuating the CSIS-increased glycolytic pathway and cytoskeleton organization proteins expression and decreased the expression of proteins involved in V-ATPase and vesicle endocytosis. Our overall findings revealed that synaptic vesicle dynamics, specifically exocytosis, and mitochondria-related energy processes might be key biological pathways modulated by the effective nootropic and antidepressant treatment with Tian and be a potential target for therapeutic efficacy of the stress-related mood disorders." @default.
- W3197268249 created "2021-09-13" @default.
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- W3197268249 date "2021-09-07" @default.
- W3197268249 modified "2023-10-11" @default.
- W3197268249 title "Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats" @default.
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- W3197268249 cites W1741112250 @default.
- W3197268249 cites W1775749144 @default.
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- W3197268249 cites W1969606502 @default.
- W3197268249 cites W1977249405 @default.
- W3197268249 cites W1978891587 @default.
- W3197268249 cites W1991842868 @default.
- W3197268249 cites W1997396304 @default.
- W3197268249 cites W2000443882 @default.
- W3197268249 cites W2008101652 @default.
- W3197268249 cites W2011110465 @default.
- W3197268249 cites W2013586266 @default.
- W3197268249 cites W2015063347 @default.
- W3197268249 cites W2021235911 @default.
- W3197268249 cites W2024985387 @default.
- W3197268249 cites W2025076792 @default.
- W3197268249 cites W2034279055 @default.
- W3197268249 cites W2035237772 @default.
- W3197268249 cites W2040595230 @default.
- W3197268249 cites W2041036432 @default.
- W3197268249 cites W2041896252 @default.
- W3197268249 cites W2050276270 @default.
- W3197268249 cites W2053576965 @default.
- W3197268249 cites W2054698000 @default.
- W3197268249 cites W2061863029 @default.
- W3197268249 cites W2067535960 @default.
- W3197268249 cites W2068677212 @default.
- W3197268249 cites W2075233434 @default.
- W3197268249 cites W2078047436 @default.
- W3197268249 cites W2079853603 @default.
- W3197268249 cites W2085010169 @default.
- W3197268249 cites W2085339275 @default.
- W3197268249 cites W2089299823 @default.
- W3197268249 cites W2091264006 @default.
- W3197268249 cites W2092043738 @default.
- W3197268249 cites W2093484024 @default.
- W3197268249 cites W2095080503 @default.
- W3197268249 cites W2097828712 @default.
- W3197268249 cites W2104196253 @default.
- W3197268249 cites W2107611011 @default.
- W3197268249 cites W2119260049 @default.
- W3197268249 cites W2120955727 @default.
- W3197268249 cites W2127218801 @default.
- W3197268249 cites W2129411932 @default.
- W3197268249 cites W2140687548 @default.
- W3197268249 cites W2142790764 @default.
- W3197268249 cites W2156893469 @default.
- W3197268249 cites W2166878763 @default.
- W3197268249 cites W2168202212 @default.
- W3197268249 cites W2238590368 @default.
- W3197268249 cites W2289753514 @default.
- W3197268249 cites W2291443053 @default.
- W3197268249 cites W2322761635 @default.
- W3197268249 cites W2341046893 @default.
- W3197268249 cites W2460778061 @default.
- W3197268249 cites W2494988103 @default.
- W3197268249 cites W2511946169 @default.
- W3197268249 cites W2580279138 @default.
- W3197268249 cites W2610426560 @default.
- W3197268249 cites W2751490737 @default.
- W3197268249 cites W2773270029 @default.
- W3197268249 cites W2778743820 @default.
- W3197268249 cites W2792568355 @default.
- W3197268249 cites W2802530085 @default.
- W3197268249 cites W2883421583 @default.
- W3197268249 cites W2898549133 @default.
- W3197268249 cites W2899760200 @default.
- W3197268249 cites W2933363539 @default.
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- W3197268249 doi "https://doi.org/10.1038/s41598-021-97186-7" @default.
- W3197268249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8423821" @default.
- W3197268249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34493757" @default.
- W3197268249 hasPublicationYear "2021" @default.
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