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- W3197293359 abstract "Apolipoprotein M (apoM) is a member of the lipocalin superfamily and is predominantly associated with high-density lipoprotein (HDL). It was found that apoM is the chaperon to the bioactive sphingolipid, sphingosine-1-phosphate (S1P). Several studies have since contributed to expand the knowledge on apoM, S1P, and the apoM/S1P-complex in cardiovascular diseases. For instance, the HDL-bound apoM/S1P complex serves as a bridge between HDL and endothelial cells, maintaining a healthy endothelial barrier. Evidence indicates, however, that the apoM/S1P complex may has both protective and harmful effects on the cardiovascular system, which suggests the need for more research to understand the interplay between these molecules. This review aims to shed light on the most recent findings on apoM/S1P-signaling and its impact on endothelial dysfunction, inflammation, and cardiovascular diseases. Finally, it will be discussed whether drugs that target apoM and/or S1P-signaling may be beneficial to patients with cardiovascular and inflammatory diseases." @default.
- W3197293359 created "2021-09-13" @default.
- W3197293359 creator A5027795927 @default.
- W3197293359 creator A5081407287 @default.
- W3197293359 date "2021-10-01" @default.
- W3197293359 modified "2023-10-18" @default.
- W3197293359 title "Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system" @default.
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- W3197293359 doi "https://doi.org/10.1016/j.atherosclerosis.2021.08.039" @default.
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- W3197293359 hasPublicationYear "2021" @default.
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