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- W3197315089 abstract "Many experimental procedures include steps where different developmental stages of zebrafish are subjected to painful or stressful procedures. Analgesia and anesthesia are in most cases used to suppress distress and/or pain sensation/perception. While anesthesia is often used mainly to immobilize animals for surgical and nonsurgical procedures, analgesia is a fairly new aspect added to zebrafish protocols to take into account the increasing awareness of pain sensation and animal welfare in fish. The decision concerning effective, safe, and humane methods of analgesia and anesthesia that are ethically justifiable as well as scientifically reproducible is still difficult and depends on the specific situation. There are different procedures with different levels of invasiveness and duration to which analgesia and anesthesia protocols must be adapted, as there is no “one size fits all.” Euthanasia or humane killing might be applied due to protocol requirements, but also to avoid more suffering, applying a final pain relief if ethical justification of a harmful state of the animal is not given. There are several euthanasia methods depending on the purpose and developmental stage of the animal. Chemical substances are involved in all the referred procedures, analgesia, anesthesia, and chemical euthanasia, thus one has to pay attention to legal considerations. In this chapter, we will discuss different protocols for analgesia, anesthesia, and euthanasia based on the different requirements of various protocols." @default.
- W3197315089 created "2021-09-13" @default.
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- W3197315089 date "2022-01-01" @default.
- W3197315089 modified "2023-09-30" @default.
- W3197315089 title "Analgesia, anesthesia, and euthanasia in zebrafish" @default.
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- W3197315089 doi "https://doi.org/10.1016/b978-0-12-821099-4.00016-x" @default.
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