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- W3197343866 abstract "Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of antibiotics. However, their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial implementation. Inspired by the hunting behavior of spiders, here, a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture and killing of bacteria. By virtue of the initiative bacteria-capturing functionality, this spiderweb-like nanoagent could effectively attract and trap bacteria through electrostatic interaction and its reticular morphology feature. Furthermore, its synergetic antibacterial mechanism combining physical membranolysis with reactive oxygen species (ROS) release allows such nanoagent to harvest a promoted bactericidal activity. Importantly, the woundplast employing the spiderweb-like nanoagent exhibits a superior antibacterial efficacy against drug-resistant Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus compared with commercially available woundplasts. This work may pave a new way for rational design of new generation bactericidal agents facing the future super-bacteria booming." @default.
- W3197343866 created "2021-09-13" @default.
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- W3197343866 date "2021-08-26" @default.
- W3197343866 modified "2023-10-17" @default.
- W3197343866 title "Bioinspired nanostructured spiderweb for high-efficiency capturing and killing of bacteria" @default.
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- W3197343866 doi "https://doi.org/10.1007/s40843-021-1746-4" @default.
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