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• W3197344562 endingPage "2351" @default.
• W3197344562 startingPage "2351" @default.
• W3197344562 abstract "The plasma glycoprotein von Willebrand factor (VWF) is exclusively synthesized in endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets. Its primary function lies in hemostasis. However, VWF is much more than just a “fishing hook” for platelets and a transporter for coagulation factor VIII. VWF is a true multitasker when it comes to its many roles in cellular processes. In ECs, VWF coordinates the formation of Weibel–Palade bodies and guides several cargo proteins to these storage organelles, which control the release of hemostatic, inflammatory and angiogenic factors. Leukocytes employ VWF to assist their rolling on, adhesion to and passage through the endothelium. Vascular smooth muscle cell proliferation is supported by VWF, and it regulates angiogenesis. The life cycle of platelets is accompanied by VWF from their budding from megakaryocytes to adhesion, activation and aggregation until the end in apoptosis. Some tumor cells acquire the ability to produce VWF to promote metastasis and hide in a shell of VWF and platelets, and even the maturation of osteoclasts is regulated by VWF. This review summarizes the current knowledge on VWF’s versatile cellular functions and the resulting pathophysiological consequences of their dysregulation." @default.
• W3197344562 created "2021-09-13" @default.
• W3197344562 creator A5048527504 @default.
• W3197344562 creator A5085878170 @default.
• W3197344562 date "2021-09-08" @default.
• W3197344562 modified "2023-10-11" @default.
• W3197344562 title "The Manifold Cellular Functions of von Willebrand Factor" @default.
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